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TY-51469 

Cat. No.: HY-12370
Handling Instructions

TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.

For research use only. We do not sell to patients.

TY-51469 Chemical Structure

TY-51469 Chemical Structure

CAS No. : 603987-59-3

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.

IC50 & Target

IC50: 0.4 nM (Simian chymase), 0.7 nM (Human chymase)[1]

In Vivo

TY-51469 shows 100% stability in rat plasma at 40°C for as long as 1 hour[1]. TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8990 mL 9.4949 mL 18.9897 mL
5 mM 0.3798 mL 1.8990 mL 3.7979 mL
10 mM 0.1899 mL 0.9495 mL 1.8990 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Rats[1]

The 2-week intravenous repeated-dose toxicity study of TY-51469 was conducted in male Sprague-Dawley rats at daily doses of 0 (control), 20, and 60 mg/kg[1].

Mice[1]

the chymase inhibitor TY-51469 was administered daily at a dose of 0.1 or 1.0 mg/kg/day for 21 days using an osmotic pump to male 8-week-old ICR mice. The osmotic pump released the drug solution continuously at a rate of 0.3 µL/h for 21 days[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

526.60

Formula

C₂₀H₁₅FN₂O₆S₄

CAS No.

603987-59-3

SMILES

O=C(C1=CSC(C2=CC=C(NS(=O)(C3=C(C)C4=CC(F)=CC=C4S3)=O)C(S(=O)(C)=O)=C2)=N1)O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
TY-51469
Cat. No.:
HY-12370
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TY-51469

Cat. No.: HY-12370