TY-51469
Based on 1 publication(s) in Google Scholar
TY-51469 is a chymase inhibitor with IC50s for simian and human chymases of 0.4 and 7.0 nM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 603987-59-3
- Formula: C20H15FN2O6S4
- Molecular Weight:526.60
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) TY-51469
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Biological Activity
IC50: 0.4 nM (Simian chymase), 0.7 nM (Human chymase)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 603987-59-3
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Appearance Solid
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Molecular Weight 526.60
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Formula C20H15FN2O6S4
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Color Off-white to light brown
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SMILES
O=C(C1=CSC(C2=CC=C(NS(=O)(C3=C(C)C4=CC(F)=CC=C4S3)=O)C(S(=O)(C)=O)=C2)=N1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Immunol
Neuronal substance P-driven MRGPRX2-dependent mast cell degranulation products differentially promote vascular permeability. [Abstract]2024 Nov 21:15:1477072. PMID: 39640264
Solvent & Solubility
DMSO : 33.33 mg/mL (63.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Rats[1]
The 2-week intravenous repeated-dose toxicity study of TY-51469 was conducted in male Sprague-Dawley rats at daily doses of 0 (control), 20, and 60 mg/kg[1].
Mice[1]
the chymase inhibitor TY-51469 was administered daily at a dose of 0.1 or 1.0 mg/kg/day for 21 days using an osmotic pump to male 8-week-old ICR mice. The osmotic pump released the drug solution continuously at a rate of 0.3 µL/h for 21 days[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8990 mL | 9.4949 mL | 18.9897 mL | 47.4744 mL |
| 5 mM | 0.3798 mL | 1.8990 mL | 3.7979 mL | 9.4949 mL | |
| 10 mM | 0.1899 mL | 0.9495 mL | 1.8990 mL | 4.7474 mL | |
| 15 mM | 0.1266 mL | 0.6330 mL | 1.2660 mL | 3.1650 mL | |
| 20 mM | 0.0949 mL | 0.4747 mL | 0.9495 mL | 2.3737 mL | |
| 25 mM | 0.0760 mL | 0.3798 mL | 0.7596 mL | 1.8990 mL | |
| 30 mM | 0.0633 mL | 0.3165 mL | 0.6330 mL | 1.5825 mL | |
| 40 mM | 0.0475 mL | 0.2374 mL | 0.4747 mL | 1.1869 mL | |
| 50 mM | 0.0380 mL | 0.1899 mL | 0.3798 mL | 0.9495 mL | |
| 60 mM | 0.0316 mL | 0.1582 mL | 0.3165 mL | 0.7912 mL |
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