2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. JNJ-10311795

JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity.

For research use only. We do not sell to patients.

JNJ-10311795 Chemical Structure

JNJ-10311795 Chemical Structure

CAS No. : 518062-14-1

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Description

JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity[1].

IC50 & Target

Ki: 38 nM (cathepsin G), 2.3 nM (chymase)[1].
Molecular Weight

670.69

Formula

C40H35N2O6P
CAS No.
SMILES

OP(O)(C(C1=C2C=CC=CC2=CC=C1)C(C3=C(C(N(C)C4CCN(C(C5=CC=C6C=CC=CC6=C5)=O)CC4)=O)C=C7C=CC=CC7=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNJ-10311795 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-10311795518062-14-1RWJ-355871JNJ10311795JNJ 10311795RWJ355871RWJ 355871Cathepsinneutrophilcathepsin GchymaseInhibitorinhibitorinhibit

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HY-122161
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