518062-14-1
518062-14-1
Chemical Structure
JNJ-10311795
Synonym(s): RWJ-355871
- No. CAS: 518062-14-1
- Formula:C40H35N2O6P
- Molecular Weight:670.69
IUPAC Name: (2-(3-((1-(2-naphthoyl)piperidin-4-yl)(methyl)carbamoyl)naphthalen-2-yl)-1-(naphthalen-1-yl)-2-oxoethyl)phosphonic acid
InChIKey: XUJQPDQURBZEGJ-UHFFFAOYSA-N
SMILES: OP(O)(C(C1=C2C=CC=CC2=CC=C1)C(C3=C(C(N(C)C4CCN(C(C5=CC=C6C=CC=CC6=C5)=O)CC4)=O)C=C7C=CC=CC7=C3)=O)=O
Biological Activity: JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity[1].
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JNJ-10311795 | JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity. | |||||||||||||||||||||
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