2. Metabolic Enzyme/Protease
  3. Proteasome
  4. INVA8001

INVA8001 (ASB17061) is a highly selective and orally active chymase inhibitor with IC50 values for human chymase and mouse mast cell proteinase 4 (mMCP-4) of 0.02 and 0.03 μM, respectively. INVA8001 exhibits IC50 values for bovine α-chymotrypsin and human cathesin G of 3.4 and 32.1 μM, respectively, and it shows over 1000-fold selectivity for other related serine proteases. INVA8001 inhibits mast cells in a mouse primary sclerosing cholangitis (PSC) model, improves bile duct pathology, and alleviates bile stasis, demonstrating anti-inflammatory and anti-fibrotic effects.

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INVA8001

INVA8001 Chemical Structure

CAS No. : 1312993-34-2

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Description

INVA8001 (ASB17061) is a highly selective and orally active chymase inhibitor with IC50 values for human chymase and mouse mast cell proteinase 4 (mMCP-4) of 0.02 and 0.03 μM, respectively. INVA8001 exhibits IC50 values for bovine α-chymotrypsin and human cathesin G of 3.4 and 32.1 μM, respectively, and it shows over 1000-fold selectivity for other related serine proteases. INVA8001 inhibits mast cells in a mouse primary sclerosing cholangitis (PSC) model, improves bile duct pathology, and alleviates bile stasis, demonstrating anti-inflammatory and anti-fibrotic effects[1].

Clinical Trial
Molecular Weight

620.09

Formula

C29H38ClN5O8
CAS No.
SMILES

[H][C@@]1(CN/C(CN(C1=O)C(N[C@](CCC)(C2=CC=C(C(N)=C2)C(O)=O)[H])=O)=N\OCC)CC3=C(C=CC(Cl)=C3)OC.CC(O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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INVA8001 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

INVA80011312993-34-2ASB17061INVA 8001INVA-8001ASB 17061ASB-17061ProteasomeChymase inhibitorPrimary sclerosing cholangitisMast cellsLiver fibrosisBiliary senescenceMdr2 knockout mouseInhibitorinhibitorinhibit

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