1312993-34-2
Chemical Structure
INVA8001
Synonym(s): ASB17061
- CAS No.: 1312993-34-2
- Formula:C29H38ClN5O8
- Molecular Weight:620.09
InChIKey: QIQXHGJOLAAJCX-VNJAQMQMSA-N
SMILES: [H][C@@]1(CN/C(CN(C1=O)C(N[C@](CCC)(C2=CC=C(C(N)=C2)C(O)=O)[H])=O)=N\OCC)CC3=C(C=CC(Cl)=C3)OC.CC(O)=O
Biological Activity: INVA8001 (ASB17061) is a highly selective and orally active chymase inhibitor with IC50 values for human chymase and mouse mast cell proteinase 4 (mMCP-4) of 0.02 and 0.03 μM, respectively. INVA8001 exhibits IC50 values for bovine α-chymotrypsin and human cathesin G of 3.4 and 32.1 μM, respectively, and it shows over 1000-fold selectivity for other related serine proteases. INVA8001 inhibits mast cells in a mouse primary sclerosing cholangitis (PSC) model, improves bile duct pathology, and alleviates bile stasis, demonstrating anti-inflammatory and anti-fibrotic effects[1].
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INVA8001 | INVA8001 (ASB17061) is a highly selective and orally active chymase inhibitor with IC50 values for human chymase and mouse mast cell proteinase 4 (mMCP-4) of 0.02 and 0.03 μM, respectively. INVA8001 exhibits IC50 values for bovine α-chymotrypsin and human cathesin G of 3.4 and 32.1 μM, respectively, and it shows over 1000-fold selectivity for other related serine proteases. INVA8001 inhibits mast cells in a mouse primary sclerosing cholangitis (PSC) model, improves bile duct pathology, and alleviates bile stasis, demonstrating anti-inflammatory and anti-fibrotic effects. | |||||||||||||||||||||
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Keywords
