Chymase-IN-1
Based on 1 Customer Validation
Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.
For research use only. We do not sell to patients.
- Purity: 99.17%
- CAS No.: 862090-74-2
- Formula: C20H15ClNO4PS
- Molecular Weight:431.83
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 29 nM (chymase)[1]
Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 862090-74-2
-
Appearance Solid
-
Molecular Weight 431.83
-
Formula C20H15ClNO4PS
-
Color White to off-white
-
SMILES
O=C(NC1=CC=C2C=CC=CC2=C1)C(P(O)(O)=O)C3=CSC4=CC=C(Cl)C=C43
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (115.79 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3157 mL | 11.5786 mL | 23.1573 mL | 57.8932 mL |
| 5 mM | 0.4631 mL | 2.3157 mL | 4.6315 mL | 11.5786 mL | |
| 10 mM | 0.2316 mL | 1.1579 mL | 2.3157 mL | 5.7893 mL | |
| 15 mM | 0.1544 mL | 0.7719 mL | 1.5438 mL | 3.8595 mL | |
| 20 mM | 0.1158 mL | 0.5789 mL | 1.1579 mL | 2.8947 mL | |
| 25 mM | 0.0926 mL | 0.4631 mL | 0.9263 mL | 2.3157 mL | |
| 30 mM | 0.0772 mL | 0.3860 mL | 0.7719 mL | 1.9298 mL | |
| 40 mM | 0.0579 mL | 0.2895 mL | 0.5789 mL | 1.4473 mL | |
| 50 mM | 0.0463 mL | 0.2316 mL | 0.4631 mL | 1.1579 mL | |
| 60 mM | 0.0386 mL | 0.1930 mL | 0.3860 mL | 0.9649 mL | |
| 80 mM | 0.0289 mL | 0.1447 mL | 0.2895 mL | 0.7237 mL | |
| 100 mM | 0.0232 mL | 0.1158 mL | 0.2316 mL | 0.5789 mL |
Chymase-IN-1 Related Classifications
HY-100269 Related Classifications
Powered by Bioz