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Chymase-IN-1 

Cat. No.: HY-100269
Handling Instructions

Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.

For research use only. We do not sell to patients.

Chymase-IN-1 Chemical Structure

Chymase-IN-1 Chemical Structure

CAS No. : 862090-74-2

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Description

Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.

IC50 & Target

IC50: 29 nM (chymase)[1]

In Vitro

Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].

In Vivo

Chymase-IN-1 exhibits low oral bioavailability in rats (F=3%; oral t1/2=1.8 h)[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

431.83

Formula

C₂₀H₁₅ClNO₄PS

CAS No.

862090-74-2

SMILES

O=C(NC1=CC=C2C=CC=CC2=C1)C(P(O)(O)=O)C3=CSC4=CC=C(Cl)C=C43

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Chymase-IN-1
Cat. No.:
HY-100269
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Chymase-IN-1

Cat. No.: HY-100269