2. Metabolic Enzyme/Protease
  3. Proteasome
  4. Chymase-IN-1

Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.

For research use only. We do not sell to patients.

Chymase-IN-1

Chymase-IN-1 Chemical Structure

CAS No. : 862090-74-2

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Based on 1 publication(s) in Google Scholar

Chymase-IN-1 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.

IC50 & Target

IC50: 29 nM (chymase)[1]
In Vitro

Chymase-IN-1 (compound 5f) is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. Results demonstrate that Chymase-IN-1 has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chymase-IN-1 Related Antibodies
In Vivo

Chymase-IN-1 exhibits low oral bioavailability in rats (F=3%; oral t1/2=1.8 h)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

431.83

Formula

C20H15ClNO4PS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC=C2C=CC=CC2=C1)C(P(O)(O)=O)C3=CSC4=CC=C(Cl)C=C43
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (115.79 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3157 mL 11.5786 mL 23.1573 mL
5 mM 0.4631 mL 2.3157 mL 4.6315 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3157 mL 11.5786 mL 23.1573 mL 57.8932 mL
5 mM 0.4631 mL 2.3157 mL 4.6315 mL 11.5786 mL
10 mM 0.2316 mL 1.1579 mL 2.3157 mL 5.7893 mL
15 mM 0.1544 mL 0.7719 mL 1.5438 mL 3.8595 mL
20 mM 0.1158 mL 0.5789 mL 1.1579 mL 2.8947 mL
25 mM 0.0926 mL 0.4631 mL 0.9263 mL 2.3157 mL
30 mM 0.0772 mL 0.3860 mL 0.7719 mL 1.9298 mL
40 mM 0.0579 mL 0.2895 mL 0.5789 mL 1.4473 mL
50 mM 0.0463 mL 0.2316 mL 0.4631 mL 1.1579 mL
60 mM 0.0386 mL 0.1930 mL 0.3860 mL 0.9649 mL
80 mM 0.0289 mL 0.1447 mL 0.2895 mL 0.7237 mL
100 mM 0.0232 mL 0.1158 mL 0.2316 mL 0.5789 mL
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Chymase-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chymase-IN-1862090-74-2ProteasomeInhibitorinhibitorinhibit

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