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Fas/FasL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	FASTK (2) AMPK (2) Apoptosis (6) Calcium Channel (1) Caspase (3) Epigenetic Reader Domain (2) ERK (2) Histone Methyltransferase (1) Indoleamine 2,3-Dioxygenase (IDO) (1) JNK (1) Keap1-Nrf2 (2) NF-κB (3) PERK (1) PKA (2) ROCK (2) Sirtuin (2) TNF Receptor (1) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (6) Inflammation/Immunology (5) Metabolic Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: FASTK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150190

F5446 1 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
F5446 (Compound 1) is a selective small molecule inhibitor of SUV39H1 methyltransferase. F5446 decreases H3K9me3 deposition at the FAS promoter, increases Fas expression and increases colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. F5446 suppresses human colon tumor xenograft growth in vivo .

HY-P10102

Kp7-6 2 Publications Verification	Apoptosis PERK NF-κB Caspase JNK	Inflammation/Immunology Cancer
Kp7-6 is a *Fas* mimetic peptide and also a *Fas/FasL* antagonist. Kp7-6 specifically binds to *Fas* and *FasL, disrupts receptor complexes, and blocks downstream apoptosis* signaling pathways. Kp7-6 inhibits the phosphorylation of ERK1-2, induces the phosphorylation of IκBα, and activates NF-κB. Kp7-6 inhibits the activation of caspase-8, caspase-3 and JNK, and suppresses human amylin-induced β-cell apoptosis. Kp7-6 inhibits *FasL*-induced lymphoid cytotoxicity and apoptosis. Kp7-6 reduces local tumor *FasL* expression, increases CD8 ⁺Fas ⁺ T cell infiltration, and decreases tumor volume in pancreatic neuroendocrine tumor models. Kp7-6 prevents concanavalin A-induced liver injury in mice. Kp7-6 is applicable to research related to type 2 diabetes, concanavalin A-induced hepatitis and pancreatic neuroendocrine tumors .

HY-133897

(Rac)-Indoximod 1 Publications Verification 1-Methyl-DL-tryptophan; (Rac)-NLG-8189	Indoleamine 2,3-Dioxygenase (IDO) Apoptosis	Inflammation/Immunology Cancer
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes .

HY-N12378

β-Patchoulene	NF-κB Toll-like Receptor (TLR) PKA Epigenetic Reader Domain Keap1-Nrf2 Sirtuin AMPK Caspase FASTK ERK ROCK Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
β-Patchoulene is an orally active anti-inflammatory, antioxidant, and anti-apoptotic agent. β-Patchoulene inhibits the NF-κB, TLR4, and cAMP/PKA/CREB signaling pathways; activates the Sirt1/Nrf2 and AMPK signaling pathways; and targets *Fas/FasL*, Caspase-3, ERK1/2, ROCK1/MLC2 for inhibition. β-Patchoulene regulates cytokine secretion, inflammatory cell infiltration, lipid peroxidation, cell polarization, gut microbiota, and lipid metabolism, restores barrier function, mitochondrial function, and cell viability, and exhibits repellent activity against Spodoptera exigua larvae. β-Patchoulene can be used in research related to various inflammatory, ischemic, fibrosis-associated diseases, as well as hepatocellular carcinoma .

HY-P10815

IP3RCYT	Apoptosis Calcium Channel	Others
IP3RCYT is an IP₃R inhibitory peptide, which can inhibit the binding of cytochrome C to IP₃R with an IC₅₀ about 100 nM. IP3RCYT regulates calcium signaling within cells. P3RCYT inhibits apoptosis in HeLa and Jurkat cells treated with Staurosporine (HY-15141) or Membrane-bound Fas ligand (FasL) .

HY-P99133

Anti-Mouse Fas Ligand Antibody (MFL3)	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse Fas Ligand Antibody (MFL3) is an anti-mouse Fas Ligand IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse Fas Ligand Antibody (MFL3) can block Fas Ligand (FasL). Anti-Mouse Fas Ligand Antibody (MFL3) can be used for the researches of cancer and immunology .

HY-N12378A

α-Patchoulene	AMPK FASTK Sirtuin ROCK Keap1-Nrf2 Toll-like Receptor (TLR) Apoptosis PKA ERK NF-κB Epigenetic Reader Domain Caspase	Metabolic Disease Inflammation/Immunology Cancer
α-Patchoulene is an orally active anti-inflammatory, antioxidant, and anti-apoptotic agent. α-Patchoulene inhibits the NF-κB, TLR4, and cAMP/PKA/CREB signaling pathways; activates the Sirt1/Nrf2 and AMPK signaling pathways; and targets *Fas/FasL*, Caspase-3, ERK1/2, ROCK1/MLC2 for inhibition. α-Patchoulene regulates cytokine secretion, inflammatory cell infiltration, lipid peroxidation, cell polarization, gut microbiota, and lipid metabolism, restores barrier function, mitochondrial function, and cell viability, and exhibits repellent activity against Spodoptera exigua larvae. α-Patchoulene can be used in research related to various inflammatory, ischemic, fibrosis-associated diseases, as well as hepatocellular carcinoma .

Cat. No.	Product Name	Target	Research Area

HY-P10102

Kp7-6 2 Publications Verification	Apoptosis PERK NF-κB Caspase JNK	Inflammation/Immunology Cancer
Kp7-6 is a *Fas* mimetic peptide and also a *Fas/FasL* antagonist. Kp7-6 specifically binds to *Fas* and *FasL, disrupts receptor complexes, and blocks downstream apoptosis* signaling pathways. Kp7-6 inhibits the phosphorylation of ERK1-2, induces the phosphorylation of IκBα, and activates NF-κB. Kp7-6 inhibits the activation of caspase-8, caspase-3 and JNK, and suppresses human amylin-induced β-cell apoptosis. Kp7-6 inhibits *FasL*-induced lymphoid cytotoxicity and apoptosis. Kp7-6 reduces local tumor *FasL* expression, increases CD8 ⁺Fas ⁺ T cell infiltration, and decreases tumor volume in pancreatic neuroendocrine tumor models. Kp7-6 prevents concanavalin A-induced liver injury in mice. Kp7-6 is applicable to research related to type 2 diabetes, concanavalin A-induced hepatitis and pancreatic neuroendocrine tumors .

HY-P10815

IP3RCYT	Apoptosis Calcium Channel	Others
IP3RCYT is an IP₃R inhibitory peptide, which can inhibit the binding of cytochrome C to IP₃R with an IC₅₀ about 100 nM. IP3RCYT regulates calcium signaling within cells. P3RCYT inhibits apoptosis in HeLa and Jurkat cells treated with Staurosporine (HY-15141) or Membrane-bound Fas ligand (FasL) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99133

Anti-Mouse Fas Ligand Antibody (MFL3)	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse Fas Ligand Antibody (MFL3) is an anti-mouse Fas Ligand IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse Fas Ligand Antibody (MFL3) can block Fas Ligand (FasL). Anti-Mouse Fas Ligand Antibody (MFL3) can be used for the researches of cancer and immunology .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12378

β-Patchoulene	Other Terpenoids Structural Classification Entada phaseoloides (L.) Merr. Terpenoids Labiatae Plants Source Classification	NF-κB Toll-like Receptor (TLR) PKA Epigenetic Reader Domain Keap1-Nrf2 Sirtuin AMPK Caspase FASTK ERK ROCK Apoptosis
β-Patchoulene is an orally active anti-inflammatory, antioxidant, and anti-apoptotic agent. β-Patchoulene inhibits the NF-κB, TLR4, and cAMP/PKA/CREB signaling pathways; activates the Sirt1/Nrf2 and AMPK signaling pathways; and targets *Fas/FasL*, Caspase-3, ERK1/2, ROCK1/MLC2 for inhibition. β-Patchoulene regulates cytokine secretion, inflammatory cell infiltration, lipid peroxidation, cell polarization, gut microbiota, and lipid metabolism, restores barrier function, mitochondrial function, and cell viability, and exhibits repellent activity against Spodoptera exigua larvae. β-Patchoulene can be used in research related to various inflammatory, ischemic, fibrosis-associated diseases, as well as hepatocellular carcinoma .

HY-N12378A

α-Patchoulene	Structural Classification Entada phaseoloides (L.) Merr. Terpenoids Labiatae Sesquiterpenes Plants Source Classification	AMPK FASTK Sirtuin ROCK Keap1-Nrf2 Toll-like Receptor (TLR) Apoptosis PKA ERK NF-κB Epigenetic Reader Domain Caspase
α-Patchoulene is an orally active anti-inflammatory, antioxidant, and anti-apoptotic agent. α-Patchoulene inhibits the NF-κB, TLR4, and cAMP/PKA/CREB signaling pathways; activates the Sirt1/Nrf2 and AMPK signaling pathways; and targets *Fas/FasL*, Caspase-3, ERK1/2, ROCK1/MLC2 for inhibition. α-Patchoulene regulates cytokine secretion, inflammatory cell infiltration, lipid peroxidation, cell polarization, gut microbiota, and lipid metabolism, restores barrier function, mitochondrial function, and cell viability, and exhibits repellent activity against Spodoptera exigua larvae. α-Patchoulene can be used in research related to various inflammatory, ischemic, fibrosis-associated diseases, as well as hepatocellular carcinoma .

Species:	Human (5) Mouse (1)
Tag:	His (6)
Source:	HEK293 (2) P. pastoris (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700520

	Fas Ligand Protein, Human (His) 1 Publications Verification Apoptosis antigen ligand ; APTLCD95 ligand ; CD95-LFas antigen ligand ; Fas ligand ; FasL; CD178	Human	E. coli
	FASLG protein binds to TNFRSF6/FAS and triggers apoptotic signals.Fas Ligand Protein, Human (His) is the recombinant human-derived FASLG protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700521

	Fas Ligand Protein, Human (P.pastoris, His) Apoptosis antigen ligand ; APTLCD95 ligand ; CD95-LFas antigen ligand ; Fas ligand ; FasL; CD178	Human	P. pastoris
	FASLG protein binds to TNFRSF6/FAS and triggers apoptotic signals. Fas Ligand Protein, Human (P.pastoris, His) is the recombinant human-derived FASLG protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P74157

	Fas Ligand Protein, Mouse (P.pastoris, His) Tumor necrosis factor ligand superfamily member 6; APTL; CD95-L; Fas ligand; FasL; CD178; TNFSF6	Mouse	P. pastoris
	Fas Ligand (CD178; APTL) is a ligand to TNFRSF6/FAS, transduces the apoptotic signal to regulate cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Mouse Fas Ligand has a total length of 279 amino acids (M1-L279), with a TNF_2 domain (144-279 a.a.). Fas Ligand Protein, Mouse (P.pastoris, His) is a recombinant protein expressed in P.pastoris cells with N-terminal His-tag.

HY-P72658

	Fas Ligand Protein, Human (HEK293, His, solution) 1 Publications Verification Tumor necrosis factor ligand superfamily member 6; APTL; CD95-L; Fas ligand; FasL; CD178; TNFSF6	Human	HEK293
	Fas Ligand (CD178; APTL) is a ligand to TNFRSF6/FAS/CD95, transduces the apoptotic signal to regulate cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Human Fas Ligand exhibits 4 isoforms, the soluble form (130-281 a.a.) of which plays an important role in the activation-induced cell death (AICD) of T lymphocytes Jurkat cells. However the membrane-bound isoform could be responsible for its inflammatory activity. Fas Ligand Protein, Human (HEK293, His, solution) has a total length of 148 amino acids (P134-L281), is expressed in HEK392 cells with N-terminal 6*His-tag.

HY-P72658A

	Fas Ligand Protein, Human (HEK293, N-His) Tumor necrosis factor ligand superfamily member 6; APTL; CD95-L; Fas ligand; FasL; CD178; TNFSF6	Human	HEK293
	Fas Ligand (CD178; APTL) is a ligand to TNFRSF6/FAS/CD95, transduces the apoptotic signal to regulate cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Human Fas Ligand exhibits 4 isoforms, the soluble form (130-281 a.a.) of which plays an important role in the activation-induced cell death (AICD) of T lymphocytes Jurkat cells. However the membrane-bound isoform could be responsible for its inflammatory activity. Fas Ligand Protein, Human (HEK293, His) has a total length of 148 amino acids (P134-L281), is expressed in HEK392 cells with N-terminal 6*His-tag.

HY-P74158

	Fas Ligand Protein, Human (148a.a, P.pastoris, His) Tumor necrosis factor ligand superfamily member 6; APTL; CD95-L; Fas ligand; FasL; CD178; TNFSF6	Human	P. pastoris
	Fas Ligand (CD178; APTL) is a ligand to TNFRSF6/FAS, transduces the apoptotic signal to regulate cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Human Fas Ligand exhibits 4 isoforms, the soluble form (130-281 a.a.) of which plays an important role in the activation-induced cell death (AICD) of T lymphocytes Jurkat cells. However the membrane-bound isoform could be responsible for its inflammatory activity. Fas Ligand Protein, Human (148a.a, P.pastoris, His) has a total length of 148 amino acids (P134-L281), with a TNF_2 domain (146-281 a.a.). It is a recombinant protein expressed in P.pastoris cells with N-terminal His-tag.

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Host:	Mouse (2)
Reactivity:	Human (2)
Application:	ICC/IF (2) FC (2) ELISA (2)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

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HY-P84345

	Fas Ligand Antibody (YA4042) FasLG; APTL; FasL; CD95L; ALPS1B; CD95-L; TNFSF6; TNLG1A; APT1LG1; Fas Ligand Antibody	ICC/IF, FC, ELISA	Human
	Fas Ligand Antibody (YA4042) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Fas Ligand.

HY-P84345A

	Fas Ligand Antibody (YA4042)(PBS only) FasLG; APTL; FasL; CD95L; ALPS1B; CD95-L; TNFSF6; TNLG1A; APT1LG1; Fas Ligand Antibody	ICC/IF, FC, ELISA	Human
	Fas Ligand Antibody (YA4042) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Fas Ligand.

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Fas/FasL

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Antibodies

Natural
Products