Anti-Mouse Fas Ligand Antibody (MFL3)
Anti-Mouse Fas Ligand Antibody (MFL3) is an anti-mouse Fas Ligand IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse Fas Ligand Antibody (MFL3) can block Fas Ligand (FasL). Anti-Mouse Fas Ligand Antibody (MFL3) can be used for the researches of cancer and immunology.
For research use only. We do not sell to patients.
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Armenian Hamster IgG
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
Fas Ligand
In Vivo
Anti-Mouse Fas Ligand Antibody (MFL3) (10-200 μg, i.p., a single dose) prolongs survival in Cisplatin (HY-17394)-induced acute kidney failure mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice bearing 3e6 heterogeneous tumor[1]
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Dosage:500 μg for the first time and 250 μg every 3 days from the day of adoptive T cell transfer
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Administration:Intraperitoneally injection
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Result:Impaired CAR-T efficacy.
Reduced survival of mice.
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Animal Model:Cisplatin (HY-17394)-induced acute kidney failure C57/B6N mice[1]
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Dosage:10, 50 and 200 μg
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Administration:Intraperitoneally injection
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Result:Reduced serum urea and serum creatinine.
Reduced the renal damage score and apoptotic cells.
Prolonged survival of mice.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo FasL blockade; In vitro FasL blockade; Functional assay; Immunohistochemistry (paraffin);
Chemical Information
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Molecular Weight 150 kDa
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SMILES
[Anti-Mouse Fas Ligand Antibody (MFL3)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Upadhyay R, et al. A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy. Cancer Discov. 2021 Mar;11(3):599-613. [Content Brief]
[2]. Linkermann A, et al. Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure. Kidney Int. 2011 Jan;79(2):169-78. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse Fas Ligand Antibody (MFL3) Related Classifications
HY-P99133 Related Classifications
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