Fasl - Fas ligand (TNF superfamily, member 6) Gene

Also Known as gld; CD178; CD95L; Fas-L; Faslg; CD95-L; Tnfsf6; Tnlg1a; APT1LG1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14103

Summary

Predicted to enable death receptor binding activity and tumor necrosis factor receptor binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic Cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand). [provided by Alliance of Genome Resources, Apr 2022]

Fasl Products (2)

mRNA Protein Name
NM_001205243.1 NP_001192172.1 tumor necrosis factor ligand superfamily member 6 isoform 2
NM_010177.4 NP_034307.1 tumor necrosis factor ligand superfamily member 6 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic signaling pathway IDA
IDA: Inferred from direct assay
7511063 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: Inferred from direct assay
10588860 MGI
acts upstream of or within retinal cell programmed cell death IMP
IMP: Inferred from mutant phenotype
14517994 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
20404348 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
16973387 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 6

  • CD95 ligand

  • Fas antigen ligand

  • generalized lymphoproliferative disease

  • tumor necrosis factor ligand 1a

Recombinant Fasl Proteins

Cat. No. Product Name Accession Purity
HY-P74157 Fas Ligand Protein, Mouse (P.pastoris, His) Q544E9 (P132-L279) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700176AF Animal-Free Fas Ligand Protein, Mouse (His) Q544E9 (Q128-L279) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150190 F5446 99.73% Unkown
HY-P10102 Kp7-6 99.28% Unkown
HY-108610A Edelfosine 99.0% Unkown
HY-133897 (Rac)-Indoximod 99.60% Unkown
HY-N7400 Phaseoloidin 99.92% Unkown
HY-153161 CASP8-IN-1 Inhibitor 98.97% Unkown
HY-N12378 β-Patchoulene 96.88% Unkown
HY-P10815 IP3RCYT Inhibitor 95.87% Unkown
HY-P11865 Ac-ATS010-KE Inhibitor / Unkown
HY-RS04752 FASLG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W989139 Perforin-IN-3 Control / Unkown
HY-RS24163 Faslg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99133 Anti-Mouse Fas Ligand Antibody (MFL3) Inhibitor / Unkown
HY-P991868 Anti-FasL Antibody / Unkown