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Results for "

IL-31

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

4

Inhibitory Antibodies

13

Recombinant Proteins

Recombinant Proteins Recommended:
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Cat. No. Compare Product Name Species Source
  • HY-P700123AF
    Animal-Free IL-31 Protein, Human (His)

    IL31; IL-31; Interleukin-31; Interleukin 31

    		 Human E. coli
    IL-31, a multifunctional cytokine, activates STAT3, and potentially STAT1 and STAT5, through the IL-31 heterodimeric receptor (IL31RA and OSMR). Known for its involvement in skin immunity, IL-31 modulates immune responses. Beyond immunity, IL-31 enhances myeloid progenitor cell survival, indicating roles in diverse cellular processes. Moreover, IL-31 induces key gene expression, including RETNLA and serum amyloid A protein, in macrophages, suggesting broader impacts on inflammatory and immune-related pathways. Animal-Free IL-31 Protein, Human (His) is the recombinant human-derived animal-FreeIL-31 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-31 Protein, Human (His) is 141 a.a., with molecular weight of ~16.78 kDa.
  • HY-P700207AF
    Animal-Free IL-31 Protein, Mouse (His)

    IL31; IL-31; Interleukin-31

    		 Mouse E. coli
    IL-31 Protein activates STAT3, potentially STAT1 and STAT5, through the IL31 receptor. It enhances myeloid progenitor cell survival and induces RETNLA and serum amyloid A protein expression in macrophages. IL-31 Protein's diverse functions suggest its importance in biological processes and potential implications in immune regulation and cell survival. Animal-Free IL-31 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-31 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-31 Protein, Mouse (His) is 140 a.a., with molecular weight of ~16.56 kDa.
  • HY-P73209
    IL-31 Protein, Human (HEK293, His)

    IL31; IL-31; Interleukin-31

    		 Human HEK293
    IL-31, a multifunctional cytokine, activates STAT3, and potentially STAT1 and STAT5, through the IL-31 heterodimeric receptor (IL31RA and OSMR). Known for its involvement in skin immunity, IL-31 modulates immune responses. Beyond immunity, IL-31 enhances myeloid progenitor cell survival, indicating roles in diverse cellular processes. Moreover, IL-31 induces key gene expression, including RETNLA and serum amyloid A protein, in macrophages, suggesting broader impacts on inflammatory and immune-related pathways. IL-31 Protein, Human (HEK293, His) is the recombinant human-derived IL-31 protein, expressed by HEK293, with C-His labeled tag. The total length of IL-31 Protein, Human (HEK293, His) is 141 a.a., with molecular weight of ~25 kDa.
  • HY-P74804
    IL-31 Protein, Mouse (HEK293, His)

    IL31; IL-31; Interleukin-31

    		 Mouse HEK293
    IL-31 Protein activates STAT3, potentially STAT1 and STAT5, through the IL31 receptor. It enhances myeloid progenitor cell survival and induces RETNLA and serum amyloid A protein expression in macrophages. IL-31 Protein's diverse functions suggest its importance in biological processes and potential implications in immune regulation and cell survival. IL-31 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-31 protein, expressed by HEK293, with C-His labeled tag. The total length of IL-31 Protein, Mouse (HEK293, His) is 163 a.a., with molecular weight of ~17.1 kDa.
  • HY-P77006
    IL-31 Protein, Cynomolgus (HEK293, His)

    IL31; IL-31; Interleukin-31

    		 Cynomolgus HEK293
    IL-31 is a multifunctional cytokine that activates STAT3 through IL-31 heterodimeric receptors (IL31RA and OSMR) and may activate STAT1 and STAT5. IL-31 is known for its involvement in skin immunity, where it regulates immune responses. IL-31 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-31 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-31 Protein, Cynomolgus (HEK293, His) is 137 a.a., with molecular weight of 19-23 KDa.
  • HY-P7217
    IL-31 Protein, Human

    rHuIL-31; IL31

    		 Human E. coli
    IL-31 Protein, Human is a novel T-helper-lymphocyte-derived cytokine that plays an important role in allergic skin inflammation and atopic dermatitis.
  • HY-P77706
    IL-31 Protein, Cynomolgus (137a.a, HEK293, His)

    Interleukin-31; IL-31; IL31

    		 Cynomolgus HEK293
    IL-31 is a multifunctional cytokine that activates STAT3 through IL-31 heterodimeric receptors (IL31RA and OSMR) and may activate STAT1 and STAT5. IL-31 is known for its involvement in skin immunity, where it regulates immune responses. IL-31 Protein, Cynomolgus (137a.a, HEK293, His) is the recombinant cynomolgus-derived IL-31 protein, expressed by HEK293 , with N-His labeled tag. The total length of IL-31 Protein, Cynomolgus (137a.a, HEK293, His) is 137 a.a., with molecular weight of 23-30 kDa.
  • HY-P78333
    OSMR beta Protein, Mouse (HEK293, His)

    IL-31R subunit beta; IL-31R-beta; IL-31RB; OSMR beta; OSMR; OSMRB; OSMRBMGC150626; PLCA1 ; IL-31R subunit β; IL-31R-β; OSMR β

    		 Mouse HEK293
    The OSMR beta Protein, in partnership with IL31RA, constitutes the IL31 receptor, binding IL31 to activate STAT3, and potentially STAT1 and STAT5. OSMR beta also transduces OSM-specific signaling. It forms a heterodimer with IL6ST, creating the type II OSM receptor, and another heterodimer with IL31RA for the IL31 receptor. OSMR beta Protein, Mouse (HEK293, His) is the recombinant mouse-derived OSMR beta protein, expressed by HEK293, with C-His labeled tag. The total length of OSMR beta Protein, Mouse (HEK293, His) is 714 a.a., with molecular weight of 115-140 kDa.
  • HY-P700806
    OSMR beta Protein, Cynomolgus (HEK293, His)

    IL-31R subunit beta; IL-31R-beta; IL-31RB; OSMR beta; OSMR; OSMRB; OSMRBMGC150626; PLCA1 ; IL-31R subunit β; IL-31R-β; OSMR β

    		 Cynomolgus HEK293
    OSMR beta Protein, a type I cytokine receptor in the type 2 subfamily, is pivotal in cellular signaling and immune responses. Serving as the receptor for oncostatin M, a cytokine with roles in inflammation, cell growth, and differentiation, OSMR beta is crucial for downstream signaling and cellular function regulation. Exploring OSMR beta's function and regulation offers insights for developing therapeutic strategies addressing diseases associated with cytokine signaling or immune response dysregulation. OSMR beta Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived OSMR beta protein, expressed by HEK293, with C-His labeled tag. The total length of OSMR beta Protein, Cynomolgus (HEK293, His) is 710 a.a., with molecular weight of 110-130 kDa.
  • HY-P75859
    IL-31R alpha Protein, Human (HEK293, Fc)

    Interleukin-31 receptor subunit alpha; IL-31R-alpha; IL-31RA; GLM-R; GLM-R; CRL3

    		 Human HEK293
    IL-31R alpha Proteinas associates with IgM heavy and light chains, aiding IgM assembly and secretion. It may act as a molecular chaperone or oxidoreductase, showing low oxidoreductase activity. Isoform 2 might regulate apoptosis. IL-31R alpha contributes to peripheral B-cell function diversification by modulating Ca(2+) stores, antibody secretion, and integrin activation. Additionally, it acts as a hormone-regulated adipokine/inflammatory cytokine, involved in chronic inflammation, impacting cellular expansion and insulin response in adipocytes, potentially contributing to insulin resistance onset. IL-31R alpha Protein, Human (HEK293, Fc) is the recombinant human-derived IL-31R alpha protein, expressed by HEK293, with C-hFc labeled tag. The total length of IL-31R alpha Protein, Human (HEK293, Fc) is 497 a.a., with molecular weight of ~130 kDa.
  • HY-P75860
    IL-31R alpha Protein, Human (HEK293, His)

    Interleukin-31 receptor subunit alpha; IL-31R-alpha; IL-31RA; GLM-R; GLM-R; CRL3

    		 Human HEK293
    IL-31R alpha Proteinas associates with IgM heavy and light chains, aiding IgM assembly and secretion. It may act as a molecular chaperone or oxidoreductase, showing low oxidoreductase activity. Isoform 2 might regulate apoptosis. IL-31R alpha contributes to peripheral B-cell function diversification by modulating Ca(2+) stores, antibody secretion, and integrin activation. Additionally, it acts as a hormone-regulated adipokine/inflammatory cytokine, involved in chronic inflammation, impacting cellular expansion and insulin response in adipocytes, potentially contributing to insulin resistance onset. IL-31R alpha Protein, Human (HEK293, His) is the recombinant human-derived IL-31R alpha protein, expressed by HEK293, with C-His labeled tag. The total length of IL-31R alpha Protein, Human (HEK293, His) is 516 a.a., with molecular weight of ~58.2 kDa.
  • HY-P77968
    IL-31R alpha Protein, Mouse (HEK293, His)

    IL-31RA; IL-31R-alpha; Gp130-like receptor; CRL3; GPL; ZcytoR17; GLM-R; CRL3Glmr; GLM-RMGC125346; PRO21384

    		 Mouse HEK293
    The IL-31R alpha protein is critical to the immune response and forms the interleukin 31 receptor with OSMR. It activates STAT3, and to a lesser extent STAT1 and STAT5, is associated with skin immunity and mediates IL31-induced itch, possibly involving the cation channels TRPA1 and TRPV1. IL-31R alpha Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-31R alpha protein, expressed by HEK293 , with a C-His labeled tag. The total length of IL-31R alpha Protein, Mouse (HEK293, His) is 481 a.a., with molecular weight of 80-115 kDa.
  • HY-P72500
    OSMR beta Protein, Human (712a.a, HEK293, His)

    Oncostatin-M-specific receptor subunit beta; IL-31R-beta; IL-31RB; OSMR; OSMRB

    		Human HEK293
    The OSMR beta protein is critical in immune responses by binding to IL12RB1 to form the interleukin 23 receptor with IL-23R. It binds to IL23 and activates T cells, NK cells and potentially macrophages/myeloid cells through Jak-Stat signaling. OSMR beta Protein, Human (712a.a, HEK293, His) is the recombinant human-derived OSMR beta protein, expressed by HEK293 , with C-6*His labeled tag. The total length of OSMR beta Protein, Human (712a.a, HEK293, His) is 712 a.a., with molecular weight of ~132 kDa.

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