Lokivetmab
Based on 1 Customer Validation
Lokivetmab (Anti-Canine IL31 Recombinant Antibody) is an anti-canine IL-31 monoclonal antibody. Lokivetmab inhibits IL-31-mediated activation of pruritogenic signals in peripheral sensory neurons and reduces TH2-weighted inflammation. Lokivetmab demonstrates long-term efficacy in controlling pruritus and improving skin lesions in dogs with canine atopic dermatitis (CAD). Lokivetmab can be used for the research of atopic dermatitis (AD) in dogs.
For research use only. We do not sell to patients.
- Purity: ≥99.0%
- CAS No.: 1533403-95-0
- Molecular Weight:147.51 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Canine IgG2 kappa
Canine
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IL-31 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Canine atopic dermatitis (CAD) dog model[1]
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Dosage:2 mg/kg
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Administration:i.v. injection, every 4-8 weeks, 12 months
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Result:Achieved pruritus control with 87% (64/75) of dogs maintaining PVAS below baseline.
Improved skin lesions with mean VetVAS (skin lesion score).
256353430 [NCBI]
BAH97742
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG2-kappa
ELISA, FACS, Functional assay
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Immobilized IL-31 Protein, Canine (HEK293, His, HY-P703718) can bind Lokivetmab. The EC50 for this effect is 59.37 ng/mL.
Chemical Information
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CAS No. 1533403-95-0
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Appearance Liquid
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Molecular Weight 147.51 kDa
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Color Colorless to light yellow
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SMILES
[Lokivetmab]
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Synonyms
Anti-Canine IL31 Recombinant Antibody; CAN34D3-65; PF-06443537
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)