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Cat. No.: HY-P99162

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Biologically Validated

Nemolizumab

Name: Nemolizumab
Brand: MedChemExpress
SKU: HY-P99162
Price: 220.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: CIM331; CD14152)

Customer Review

Based on 1 Customer Validation

Nemolizumab (CIM331) is a humanized monoclonal antibody that targets the human interleukin-31 receptor a, preventing interleukin-31 (IL-31) from binding to its receptor and the subsequent signaling. Nemolizumab can help reduce itching and sleep disturbances, and it is being studied for atopic dermatitis (AD).

For research use only. We do not sell to patients.

Purity : 99.70%
CAS No.: 1476039-58-3
Molecular Weight:144.92 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nemolizumab Chemical Structure

CAS No.: 1476039-58-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Isotype

Human IgG2 kappa

Recommend Isotype Controls

Human IgG2 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

IL-31Ra

All Interleukin Related Isoforms :

In Vitro

Nemolizumab (0.01-100 ng/mL, 2 d) inhibits the IL-31-dependent proliferation of Ba/F3 cells overexpressing hIL-31RA/cyIL-31RA and OSMR β^[3].
Nemolizumab (0.01-100 ng/mL, 2 h pretreatment + 20 min co-incubation) inhibits hIL-31 (30 ng/mL)-induced STAT3 phosphorylation in A549 cells does dependently^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nemolizumab (40-100 μg/kg, i.v., acute administration) blocks IL-31-induced scratching in cynomolgus monkeys^[3].
Nemolizumab (1 mg/kg, s.c., acute administration) exerts a mean plasma concentration of 1490 ng/mL at Day 56 in 5 of 6 experiment cynomolgus monkeys and suppresses the scratching behaviour from shortly after administration until Day 56^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

133396 [NCBI]

Accession

Q8NI17

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG2 kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized IL-31R alpha Protein, Human can bind Nemolizumab. The EC₅₀ for this effect is 17.37 ng/mL.
Loaded Nemolizumab on AHC2 biosensor, can bind IL-31R alpha Protein, Human (HEK293, His, HY-P75860) with an affinity constant of 1.825E-09 M as determined in BLI assay.

Chemical Information

CAS No. 1476039-58-3
Appearance Liquid
Molecular Weight 144.92 kDa
Color Colorless to light yellow
SMILES

[Nemolizumab]
Synonyms

CIM331; CD14152
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Nakahara T, et, al. Nemolizumab and Atopic Dermatitis: the Interaction Between Interleukin-31 and Interleukin-31 Receptor as a Potential Therapeutic Target for Pruritus in Patients With Atopic Dermatitis. 2018;5:405–14.

[2]. O Nemoto, et al. The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study. Br J Dermatol. 2016 Feb;174(2):296-304. [Content Brief]

[3]. Oyama S, et al. Cynomolgus monkey model of interleukin-31-induced scratching depicts blockade of human interleukin-31 receptor A by a humanized monoclonal antibody. Exp Dermatol. 2018 Jan;27(1):14-21. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Purity & Documentation
References

1/16

Human IgG2 kappa
1/16

Immobilized IL-31R alpha Protein, Human can bind Nemolizumab. The EC₅₀ for this effect is 17.37 ng/mL.
1/16

Loaded Nemolizumab on AHC2 biosensor, can bind IL-31R alpha Protein, Human (HEK293, His, HY-P75860) with an affinity constant of 1.825E-09 M as determined in BLI assay.
1/16

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Nemolizumab

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

Cell-ATP Viability Detection Kit

DPBS Buffer (1×)

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

All Interleukin Related Isoforms