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Indole-derivatives

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Apoptosis (1) Bacterial (2) Biochemical Assay Reagents (5) Cannabinoid Receptor (1) Cholinesterase (ChE) (1) Dopamine Receptor (1) Drug Derivative (3) Drug Intermediate (4) Endogenous Metabolite (4) HSV (3) Influenza Virus (3) Isotope-Labeled Compounds (1) Lactate Dehydrogenase (2) Lipoxygenase (1) Neurokinin Receptor (1) Phospholipase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) VSV (3)
By Research Areas:	Cancer (4) Infection (5) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (5)

By Targets:

5-HT Receptor (2)

Apoptosis (1)

Bacterial (2)

Biochemical Assay Reagents (5)

Cannabinoid Receptor (1)

Cholinesterase (ChE) (1)

Dopamine Receptor (1)

Drug Derivative (3)

Drug Intermediate (4)

Endogenous Metabolite (4)

HSV (3)

Influenza Virus (3)

Isotope-Labeled Compounds (1)

Lactate Dehydrogenase (2)

Lipoxygenase (1)

Neurokinin Receptor (1)

Phospholipase (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

VSV (3)

By Research Areas:

Cancer (4)

Infection (5)

Inflammation/Immunology (2)

Metabolic Disease (2)

Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W015650

Indole-2-carbaldehyde	Drug Derivative	Others
Indole-2-carbaldehyde is an indole derivative that can be used to reduce or remove localized fat deposits and/or tighten loose skin and soft tissues. Indole-2-carbaldehyde can be isolated from the fermentation broth of the coral symbiotic actinomycete Pseudonocardia sp. SCSIO 11457 and is used in cosmetic applications or pharmaceutical production .

HY-147216

AXKO-0046 5 Publications Verification	Lactate Dehydrogenase	Cancer
AXKO-0046, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor.AXKO-0046 has LDHB inhibitory activity with an EC₅₀ value of 42 nM.AXKO-0046 can be used for the research of cancer metabolism .

HY-W021005

Silver bis(trifluoromethanesulfonyl)imide Silver triflimide	Biochemical Assay Reagents	Others
Silver bis(trifluoromethanesulfonyl)imide is a kind of silver salt and is widely used as an organic synthesis catalyst. Silver bis(trifluoromethanesulfonyl)imide is used for the C-3 regioselective alkylation of indole derivatives with α,β -enones through conjugated addition reactions. Silver bis(trifluoromethanesulfonyl)imide can also be used as a highly efficient and stable solid-state dye sensitization and P-type dopant for perovskite solar cells .

HY-111208

CCT129957	Phospholipase	Cancer
CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC₅₀ of ~3 μM and a GC₅₀ of 15 μM. CCT129957 inhibits Ca ²⁺ release in squamous carcinoma cells at ~15 μM .

HY-Y0136

3-Indoleacetonitrile 2 Publications Verification	Endogenous Metabolite Influenza Virus HSV VSV	Infection
3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .

HY-33893

Indole-3-methanamine 2 Publications Verification	Drug Derivative Drug Intermediate	Infection
Indole-3-methanamine is an indole derivative, stress-related metabolite, and also a biosynthetic precursor of Gramine (HY-N0166). The accumulation level of Indole-3-methanamine increases in susceptible barley varieties infected with Bipolaris sorokiniana. Indole-3-methanamine can be used in studies related to barley spot blotch .

HY-147216A

AXKO-0046 dihydrochloride 5 Publications Verification	Lactate Dehydrogenase	Metabolic Disease Inflammation/Immunology Cancer
AXKO-0046 dihydrochloride, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC₅₀ value of 42 nM. AXKO-0046 dihydrochloride can be used for the research of cancer metabolism .

HY-169457

Aeruginascin	5-HT Receptor	Neurological Disease
Aeruginascin is an indole derivative and a tryptamine that can be extracted from Inocybe aeruginascens Babos . Aeruginascin may cause an euphoric mood during psychosis with hallucinations .

HY-Y0136S1

3-Indoleacetonitrile-d4	Isotope-Labeled Compounds Endogenous Metabolite Influenza Virus HSV VSV	Infection
3-Indoleacetonitrile-d₄ is deuterium labeled 3-Indoleacetonitrile (HY-Y0136). 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV.

HY-107434

Molindone (±)-Molindone; SPN-810M	Dopamine Receptor	Neurological Disease
Molindone ((±)-Molindone), an indole derivative, is a potent dopamine D2 and D5 receptor antagonist. Molindone ((±)-Molindone) can be used for the research of schizophrenia and severe mental illness .

HY-W007509

*1H-Indol-5-amine* 5-AminoIndole	Biochemical Assay Reagents Drug Intermediate	Others
1H-Indol-5-amine (5-Aminoindole) is an organic compound containing an indole ring structure and belongs to the class of indole derivatives. 1H-Indol-5-amine can serve as a key intermediate for the synthesis of other active compounds .

HY-40156

5-Fluoroindole	Bacterial Reactive Oxygen Species (ROS) Apoptosis	Infection
5-Fluoroindole is an orally active fluorinated indole derivative and antibacterial agent. 5-Fluoroindole induces ROS accumulation and triggers Apoptosis. 5-Fluoroindole inhibits the growth of pan-susceptible Mycobacterium tuberculosis (Mtb) H37Rv strains. 5-Fluoroindole has significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa) with an EC₅₀ of 15.34 μg/mL. 5-Fluoroindole introduces fluorine labeling for protein research. 5-Fluoroindole can be used in the study of tuberculosis and kiwifruit bacterial canker .

HY-Y0136R

3-Indoleacetonitrile (Standard)	Reference Standards Endogenous Metabolite Influenza Virus HSV VSV	Metabolic Disease
3-Indoleacetonitrile (Standard) is the analytical standard of 3-Indoleacetonitrile. This product is intended for research and analytical applications. 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .

HY-W009757

*Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate*	Lipoxygenase	Others
Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate is an active compound, and can be used in the synthesis of 2-phenylthiomethyl-indole derivatives, 2-phenylthiomethyl-indole derivative is a 5-lipoxygenase (5-LO) inhibitor .

HY-114880

AB-FUBINACA 3-fluorobenzyl isomer	Cannabinoid Receptor	Neurological Disease
AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid that belongs to the indole derivatives and has a high affinity for the central CB1 receptors (K_i= 0.9 nM), exhibiting anticonvulsant activity .

HY-59302

Indole-5-carboxylic acid, 98%	Biochemical Assay Reagents	Others
Indole-5-carboxylic acid, 98% is an indole derivative. Indole-5-carboxylic acid, 98% inhibits corrosion of low carbon steel in deoxygenated 0.5 M sulfuric acid solution .

HY-W010282

1,2-Dimethylindole	Drug Derivative	Cancer
1,2-Dimethylindole is an indole derivative. 1,2-Dimethylindole involves cytochrome P450-mediated oxidative reactions (e.g., hydroxylation, oxidative demethylation). 1,2-Dimethylindole is promising for research of antitumor agents and enzyme inhibitors .

HY-34502

6-Cyanoindole 6-Indolecarbonitrile	Biochemical Assay Reagents	Others
6-Cyanoindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 6-Cyanoindole is a significant indole derivative for the electron-withdrawing -C≡N group. 6-Cyanoindole can be used to generate a copolymer P(6CNIn-co-EDOT) via electrocopolymerization with EDOT .

HY-W128798

Sulfabenz	5-HT Receptor	Neurological Disease
Sulfabenz (Compound 9) is an amine-substituted N1-phenylsulfonyl indole derivative. Sulfabenz has binding activity to human 5-HT6 serotonin receptor (K_i: 200 nM). Sulfabenz can be used to study the ligand binding mechanism of 5-HT6 receptor and 5-HT6 receptor-related neurological diseases .

HY-W024881

Potassium 2,3,3-trimethylindole-5-sulfonate 2,3,3-TrimethylIndolenine-5-sulfonic acid potassium salt	Drug Intermediate	Others
Potassium 2,3,3-trimethylindole-5-sulfonate (2,3,3-Trimethylindolenine-5-sulfonic acid potassium salt) is an indole derivative containing a sodium sulfonate group and is commonly used as a key intermediate in dye synthesis. Potassium 2,3,3-trimethylindole-5-sulfonate can be coupled to peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via the sulfonyl substituent .

HY-162145

AChE-IN-54	Cholinesterase (ChE)	Inflammation/Immunology
AChE-IN-54 (compound 3c) is an inhibitor of acetylcholinesterase (AChE) and has anti-lipid oxidation activity .

HY-119552

Acetylaszonalenin LL-S490β	Endogenous Metabolite Neurokinin Receptor	Neurological Disease
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ ³H]-SP binding to human astrocytoma cells with a K_i of 170 μM .

HY-W092495

*Methyl 3-(1H-indol-3-yl)propanoate*	Drug Intermediate	Others
Methyl 3-(1H-indol-3-yl)propanoate is an indole derivative and can be used as a drug intermediate .

HY-N15065

*3-Ethyl-1,3-dihydro-3-methoxy-2H-indol-2-one*	Bacterial	Infection
3-Ethyl-1,3-dihydro-3-methoxy-2H-indol-2-one is an indole derivative and has anti-Gram-positive and negative bacteria activity .

HY-P4948

Coumarin-Phalloidin	Biochemical Assay Reagents	Others
Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton .

Cat. No.	Product Name

HY-L167

Boronic Acid Compound Library	163 compounds
Boric acid is a stable and usually non-toxic group widely used in modern synthesis to form C-C and C-heteroatom bonds. Boric acid exhibits exquisite reversible coordination characteristics and can be explored as a molecular construction tool, with specific mechanisms for controlling the structure and biological characteristics of bioconjugates. Boric acid has various activities, such as anticancer, antibacterial, and antiviral activities. In drugs, boric acid mainly exists in the form of arylboronic acid. In addition to this form, heterocycles containing boric acid, such as pyridine, pyrrole, and indole derivatives, are also very useful in pharmaceutical chemistry. Molecular modification by introducing boric acid groups into bioactive molecules has been shown to alter selectivity, physicochemical, and pharmacokinetic characteristics, and improve existing activity. MCE designs a unique collection of 163 boronic acid compounds. It is a good tool to be used for research on cancer and other diseases.

Boronic Acid Compound Library

163 compounds

Boric acid is a stable and usually non-toxic group widely used in modern synthesis to form C-C and C-heteroatom bonds. Boric acid exhibits exquisite reversible coordination characteristics and can be explored as a molecular construction tool, with specific mechanisms for controlling the structure and biological characteristics of bioconjugates. Boric acid has various activities, such as anticancer, antibacterial, and antiviral activities. In drugs, boric acid mainly exists in the form of arylboronic acid. In addition to this form, heterocycles containing boric acid, such as pyridine, pyrrole, and indole derivatives, are also very useful in pharmaceutical chemistry. Molecular modification by introducing boric acid groups into bioactive molecules has been shown to alter selectivity, physicochemical, and pharmacokinetic characteristics, and improve existing activity.

MCE designs a unique collection of 163 boronic acid compounds. It is a good tool to be used for research on cancer and other diseases.

Cat. No.	Product Name	Type

HY-W015650

Indole-2-carbaldehyde	Biochemical Assay Reagents
Indole-2-carbaldehyde is an indole derivative that can be used to reduce or remove localized fat deposits and/or tighten loose skin and soft tissues. Indole-2-carbaldehyde can be isolated from the fermentation broth of the coral symbiotic actinomycete Pseudonocardia sp. SCSIO 11457 and is used in cosmetic applications or pharmaceutical production .

HY-W021005

Silver bis(trifluoromethanesulfonyl)imide Silver triflimide	Biochemical Assay Reagents
Silver bis(trifluoromethanesulfonyl)imide is a kind of silver salt and is widely used as an organic synthesis catalyst. Silver bis(trifluoromethanesulfonyl)imide is used for the C-3 regioselective alkylation of indole derivatives with α,β -enones through conjugated addition reactions. Silver bis(trifluoromethanesulfonyl)imide can also be used as a highly efficient and stable solid-state dye sensitization and P-type dopant for perovskite solar cells .

Silver bis(trifluoromethanesulfonyl)imide

Silver triflimide

Biochemical Assay Reagents

Silver bis(trifluoromethanesulfonyl)imide is a kind of silver salt and is widely used as an organic synthesis catalyst. Silver bis(trifluoromethanesulfonyl)imide is used for the C-3 regioselective alkylation of indole derivatives with α,β -enones through conjugated addition reactions. Silver bis(trifluoromethanesulfonyl)imide can also be used as a highly efficient and stable solid-state dye sensitization and P-type dopant for perovskite solar cells .

HY-W007509

*1H-Indol-5-amine* 5-AminoIndole	Biochemical Assay Reagents
1H-Indol-5-amine (5-Aminoindole) is an organic compound containing an indole ring structure and belongs to the class of indole derivatives. 1H-Indol-5-amine can serve as a key intermediate for the synthesis of other active compounds .

HY-40156

5-Fluoroindole	Biochemical Assay Reagents
5-Fluoroindole is an orally active fluorinated indole derivative and antibacterial agent. 5-Fluoroindole induces ROS accumulation and triggers Apoptosis. 5-Fluoroindole inhibits the growth of pan-susceptible Mycobacterium tuberculosis (Mtb) H37Rv strains. 5-Fluoroindole has significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa) with an EC₅₀ of 15.34 μg/mL. 5-Fluoroindole introduces fluorine labeling for protein research. 5-Fluoroindole can be used in the study of tuberculosis and kiwifruit bacterial canker .

5-Fluoroindole

Biochemical Assay Reagents

5-Fluoroindole is an orally active fluorinated indole derivative and antibacterial agent. 5-Fluoroindole induces ROS accumulation and triggers Apoptosis. 5-Fluoroindole inhibits the growth of pan-susceptible Mycobacterium tuberculosis (Mtb) H37Rv strains. 5-Fluoroindole has significant bactericidal activity against Pseudomonas syringae pv. actinidiae (Psa) with an EC₅₀ of 15.34 μg/mL. 5-Fluoroindole introduces fluorine labeling for protein research. 5-Fluoroindole can be used in the study of tuberculosis and kiwifruit bacterial canker .

HY-59302

Indole-5-carboxylic acid, 98%	Biochemical Assay Reagents
Indole-5-carboxylic acid, 98% is an indole derivative. Indole-5-carboxylic acid, 98% inhibits corrosion of low carbon steel in deoxygenated 0.5 M sulfuric acid solution .

HY-34502

6-Cyanoindole 6-Indolecarbonitrile	Biochemical Assay Reagents
6-Cyanoindole is a biochemical reagent that can be used as a biological material or organic compound for life science related research. 6-Cyanoindole is a significant indole derivative for the electron-withdrawing -C≡N group. 6-Cyanoindole can be used to generate a copolymer P(6CNIn-co-EDOT) via electrocopolymerization with EDOT .

Cat. No.	Product Name	Target	Research Area

HY-P4948

Coumarin-Phalloidin	Biochemical Assay Reagents	Others
Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0136

3-Indoleacetonitrile 2 Publications Verification	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Influenza Virus HSV VSV
3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .

HY-33893

Indole-3-methanamine 2 Publications Verification	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Derivative Drug Intermediate
Indole-3-methanamine is an indole derivative, stress-related metabolite, and also a biosynthetic precursor of Gramine (HY-N0166). The accumulation level of Indole-3-methanamine increases in susceptible barley varieties infected with Bipolaris sorokiniana. Indole-3-methanamine can be used in studies related to barley spot blotch .

HY-Y0136R

3-Indoleacetonitrile (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Influenza Virus HSV VSV
3-Indoleacetonitrile (Standard) is the analytical standard of 3-Indoleacetonitrile. This product is intended for research and analytical applications. 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV .

HY-119552

Acetylaszonalenin LL-S490β	Alkaloids Microorganisms Indole Alkaloids Source Classification	Endogenous Metabolite Neurokinin Receptor
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ ³H]-SP binding to human astrocytoma cells with a K_i of 170 μM .

HY-N15065

*3-Ethyl-1,3-dihydro-3-methoxy-2H-indol-2-one*	Microorganisms Antibiotics Other Antibiotics Source Classification	Bacterial
3-Ethyl-1,3-dihydro-3-methoxy-2H-indol-2-one is an indole derivative and has anti-Gram-positive and negative bacteria activity .

Cat. No.	Product Name	Chemical Structure

HY-Y0136S1

3-Indoleacetonitrile-d4
3-Indoleacetonitrile-d₄ is deuterium labeled 3-Indoleacetonitrile (HY-Y0136). 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV.

3-Indoleacetonitrile-d4

3-Indoleacetonitrile-d₄ is deuterium labeled 3-Indoleacetonitrile (HY-Y0136). 3-Indoleacetonitrile is an indole derivative with anti-influenza activity. 3-Indoleacetonitrile is a plant hormone produced by cruxiferous vegetables. 3-Indoleacetonitrile exerts profound antiviral activity against a broad spectrum of influenza A viruses, HSV-1 and VSV viruses in vitro. 3-Indoleacetonitrile diminishes lung virus titers and alleviates lung lesions in vivo. 3-Indoleacetonitrile induces an increase in mitochondrial antiviral-signaling (MAVS) protein levels. 3-Indoleacetonitrile can be used in research for combating viral infections including COVID-19, HSV-1, and VSV.

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Indole-derivatives

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products