1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. CCT129957

CCT129957 

Cat. No.: HY-111208
Handling Instructions

CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM.

For research use only. We do not sell to patients.

CCT129957 Chemical Structure

CCT129957 Chemical Structure

CAS No. : 883098-58-6

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Description

CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM[1][2].

IC50 & Target

IC50: ~3 μM (Phospholipase C-γ (PLC-γ))[1]

In Vitro

The phenyl group on the left side sat in a lipophilic pocket formed of various amino acids. The predicted binding mode of CCT129957 displays a robust hydrogen bond pattern as well as a lipophilic contact[1].
CCT129957 inhibits the cell growth of renal UO-31 and the breast T-47D cancer cell lines by ~60-70%[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

309.32

Formula

C₁₇H₁₅N₃O₃

CAS No.

883098-58-6

SMILES

O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)NCCC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CCT129957CCT 129957CCT-129957PhospholipasePLC-γindoleGlu341Lys438Arg549IndoraminCa2+releaseInhibitorinhibitorinhibit

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CCT129957
Cat. No.:
HY-111208
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