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Results for "

LT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Bacterial (1) c-Myc (1) COX (2) Dengue virus (1) Epigenetic Reader Domain (1) Epoxide Hydrolase (2) FLAP (2) Flavivirus (1) FLT3 (2) HDAC (1) Interleukin Related (1) Isotope-Labeled Compounds (1) KLF (1) Leukotriene Receptor (2) LPL Receptor (1) NF-κB (2) NO Synthase (1) Parasite (1) PARP (2) PPAR (1) TNF Receptor (1)
By Research Areas:	Cancer (7) Endocrinology (1) Infection (1) Inflammation/Immunology (12) Metabolic Disease (2)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130622

LT052	Epigenetic Reader Domain	Inflammation/Immunology
LT052 is a highly selective BET BD1 inhibitor with an IC₅₀ of 87.7 nM. LT052 exhibits nanomolar BRD4 BD1 potency and 138-fold selectivity over BRD4 BD2 (IC₅₀=12.130 μM). LT052 has anti-inflammatory activity and can be used for acute gout arthritis research .

HY-121900

LT175	PPAR	Metabolic Disease Endocrinology
LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC₅₀=0.22 μm; mPPARα:EC₅₀=0.26 μm; hPPARγ:EC₅₀=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties .

HY-162378

LT-630

HDAC Inflammation/Immunology

LT-630 is a HDAC6 inhibitor. LT-630 ameliorates liver injury by reducing oxidative damage .

LT-630	HDAC	Inflammation/Immunology
LT-630 is a HDAC6 inhibitor. LT-630 ameliorates liver injury by reducing oxidative damage .

HY-155594

LT-540-717	FLT3	Cancer
LT-540-717 (compound 32) is a potent FLT3 inhibitor (IC₅₀=0.62 nM) with antiproliferative activity. LT-540-717 also inhibits several acquired FLT3 mutations, FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V). LT-540-717 has potential to be an anti-AML agent .

HY-139619

LT-850-166

FLT3 Cancer

LT-850-166 is a potent FLT3 inhibitor with the capacity of overcoming a variety of FLT3 mutations.

LT-850-166	FLT3	Cancer
LT-850-166 is a potent FLT3 inhibitor with the capacity of overcoming a variety of FLT3 mutations.

HY-P99318

Sonepcizumab LT 1009; Anti-Human S1P Recombinant Antibody	LPL Receptor	Cancer
Sonepcizumab (LT 1009) is a fully human anti-S1P monoclonal antibody. Sonepcizumab has the potential for the research of metastatic renal cell carcinoma (mRCC) .

HY-123984

LTβR-IN-1	NF-κB	Metabolic Disease
LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner .

HY-19675

Naproxen etemesil LT-NS 001; MX 1094	COX	Inflammation/Immunology
Naproxen etemesil is a lipophilic, non-acidic, inactive proagent of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC₅₀s of 8.72 and 5.15 μM, respectively in cell assay.

HY-16106

Talazoparib Maximum Cited Publications 63 Publications Verification BMN-673; LT-673	PARP	Cancer
Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with K_is of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity .

HY-16291

APTO-253 10+ Cited Publications LOR-253; LT-253	c-Myc KLF Apoptosis	Inflammation/Immunology Cancer
APTO-253 (LOR-253) is a small molecule that inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through induction of the Krüppel-like factor 4 (KLF4) tumor suppressor . APTO-253 has antiarthritic activity .

HY-16106S

Talazoparib-13C,d4 BMN-673-¹³C,d₄; LT-673-¹³C,d₄	Isotope-Labeled Compounds	Others
Talazoparib- ¹³C,d4 is ¹³C and deuterated labeled Talazoparib (HY-16106). Talazoparib is an orally active PARP 1/2 inhibitor with Ki values of 1.2 nM and 0.87 nM for inhibiting PARP1 and PARP2 enzymatic activities, respectively. Has anti-tumor activity.

HY-151619

sEH inhibitor-12	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-12 (compound 34) is a sEH inhibitor with an IC₅₀ value of 0.7 μM. sEH inhibitor-12 inhibits the 5-lipoxygenase-activating protein (FLAP)-mediated leukotriene (LT) biosynthesis with an IC₅₀ value of 2.9 μM. sEH inhibitor-12 can be used for the research of inflammation .

HY-107609

BAY-u 9773	Leukotriene Receptor	Inflammation/Immunology
BAY-u 9773 is a non-selective antagonist of the CysLT receptors (cysteinyl leukotrienes receptors) with about the same IC₅₀ for CysLT ¹ and CysLT ². BAY-u9773 is used for the inhibition of LT responses .

HY-151617

sEH inhibitor-11	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-11 (compound 35) is a sEH inhibitor with an IC₅₀ value of 0.3 μM. sEH inhibitor-11 can be used for the research of inflammation .

HY-N6607

Tryptanthrin 2 Publications Verification	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-10037

Quiflapon MK-591	FLAP Apoptosis	Inflammation/Immunology
Quiflapon (MK-591) is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor with an IC₅₀ of 1.6 nM in a FLAP binding assay. Quiflapon is also a potent and orally active Leukotriene biosynthesis (LT) inhibitor, shows IC₅₀ values of 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively. Quiflapon induces cell apoptosis .

HY-16106A

(8R,9S)-Talazoparib (8R,9S)-BMN-673; (8R,9S)-LT-673	PARP	Cancer
(8R,9S)-Talazoparib ((8R,9S)-BMN-673) is an enantiomer of Talazoparib. (8R,9S)-Talazoparib is an PARP1 inhibitor, with an IC₅₀ of 144 nM .

HY-155408

ALR-27	FLAP	Inflammation/Immunology
ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes .

HY-124801

ABMA	Flavivirus Dengue virus Bacterial Parasite	Infection
ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity .

Cat. No.	Product Name	Target	Research Area

HY-P99318

Sonepcizumab LT 1009; Anti-Human S1P Recombinant Antibody	LPL Receptor	Cancer
Sonepcizumab (LT 1009) is a fully human anti-S1P monoclonal antibody. Sonepcizumab has the potential for the research of metastatic renal cell carcinoma (mRCC) .

HY-P990034

Pateclizumab MLTA3698A; RG7415; PRO283698	Inhibitory Antibodies	Inflammation/Immunology
Pateclizumab (MLTA3698A) is a humanized antibody against lymphotoxin α (LTα), a transiently expressed cytokine on activated B and T cells (Th1, Th17), which are implicated in rheumatoid arthritis (RA) pathogenesis .

HY-P99459

Baminercept BG 9924; TT-47	Inhibitory Antibodies	Inflammation/Immunology
Baminercept (BG 9924) is a lymphotoxin β receptor IgG fusion protein (LTβR-Ig). Baminercept can be used for the research of many autoimmune diseases including primary Sjögren's syndrome (SS) and rheumatoid arthritis (RA) .

Tryptanthrin 2 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Polygonaceae Source classification Plants Inflammation/Immunology Disease Research Fields Polygonum tinctorium Ait. Indole Alkaloids	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

Species:	Human (5) Mouse (1) Cynomolgus (1)
Tag:	His (5) Tag Free (1) Avi (1) GST (1)
Source:	HEK293 (2) Sf9 insect cells (2) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P700419

	TNF-beta/TNFSF1 Protein, Human (HEK293, His) LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNF-beta; LT-alpha	Human	HEK293
	TNF-β protein acts as a homotrimeric cytokine that binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, and TNFRSF14/HVEM. TNF-beta/TNFSF1 Protein, Human (HEK293, His) is the recombinant human-derived TNF-beta/TNFSF1 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of TNF-beta/TNFSF1 Protein, Human (HEK293, His) is 171 a.a., with molecular weight of 20.8 kDa.

HY-P700154AF

	Animal-Free TNF-beta/TNFSF1 Protein, Human (His) Lymphotoxin-Alpha; LT-Alpha; TNF-beta; Tumor Necrosis Factor Ligand Superfamily Member 1; LTA; TNFB; TNFSF1	Human	E. coli
	TNF-β protein acts as a homotrimeric cytokine that binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, and TNFRSF14/HVEM. Animal-Free TNF-beta/TNFSF1 Protein, Human (His) is the recombinant human-derived animal-FreeTNF-beta/TNFSF1 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free TNF-beta/TNFSF1 Protein, Human (His) is 171 a.a., with molecular weight of ~18.65 kDa.

HY-P700612

	TNF-beta/TNFSF1 Protein, Human (HEK293, His-Avi) LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNF-beta; LT-alpha	Human	HEK293
	TNF-β protein acts as a homotrimeric cytokine that binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, and TNFRSF14/HVEM. TNF-beta/TNFSF1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived TNF-beta/TNFSF1 protein, expressed by HEK293 , with N-Avi, N-6*His labeled tag. The total length of TNF-beta/TNFSF1 Protein, Human (HEK293, His-Avi) is 171 a.a., with molecular weight of 22.7 kDa.

HY-P76482

	TNFSF3/Lymphotoxin Beta Protein, Cynomolgus (sf9, His) Lymphotoxin-beta; LT-beta; Tumor necrosis factor C; TNF-C; LTB; TNFSF3	Cynomolgus	Sf9 insect cells
	Lymphotoxin Beta (LT-beta) also known as TNFSF3, is a type II transmembrane glycoprotein of the TNF family. Lymphotoxin Beta binds to LTα to form membrane-anchored heterotrimers that activate canonical/noncanonical nuclear factor-κB (NF-κB) signaling thus inducing chemokine, cytokine or adhesion molecule expression, cell proliferation and cell survival. Lymphotoxin Beta also shows anti-inflammatory, anti-cancer activity. Lymphotoxin Beta regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury. TNFSF3/Lymphotoxin Beta Protein, Cynomolgus (sf9, His) is a recombinant protein with a N-Terminal His label, It consists of 197 amino acids (Q49-G244) and is produced in Sf9 insect cells.

HY-P700228AF

	Animal-Free TNF beta Protein, Mouse (His) TNFSF1B; Lymphotoxin-alpha (LT-α); LTalpha; LTx; TNF-be; TNFSF1; Tnf; Tnfb; Tnfsf; Tnfsf1b; Tnlg1e; hlb38; hlb382; lymph	Mouse	E. coli
	The animal-free TNF beta protein acts as a homotrimeric cytokine that binds TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, and TNFRSF14/HVEM. Animal-Free TNF beta Protein, Mouse (His) is the recombinant mouse-derived animal-FreeTNF beta protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free TNF beta Protein, Mouse (His) is 169 a.a., with molecular weight of ~19.36 kDa.

HY-P7304

	TNF-beta/TNFSF1 Protein, Human rHuTNF-β; TNF-β; TNFSF1; Lymphotoxin-alpha	Human	E. coli
	TNF-β (tumor necrosis factor β) also called lymphotoxin-α (LT-α), a member of the tumor necrosis factor superfamily, is a cytokine produced by lymphocytes. TNF-β activates the NF-κB signaling pathway, inducing cancer cell proliferation, invasion. TNF-β up-regulates genes connected with metastasis, promotes epithelial-to-mesenchymal-transition, stimulates its own expression. TNF-β mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1 Protein, Human is a recombinant protein consisting of 158 amino acids (L35-L205) and is produced in E. coli.

HY-P701740

	PHKG2 Protein, Human (Sf9, GST) PHKG2; Phosphorylase b kinase gamma catalytic chain; liver/testis isoform; PHK-gamma-LT; PHK-gamma-T; PSK-C3; Phosphorylase kinase subunit gamma-2	Human	Sf9 insect cells
	As the catalytic subunit of phosphorylase b kinase (PHK), PHKG2 plays a crucial role in the neural and hormonal regulation of glycogenolysis (glycogen breakdown) by phosphorylating and activating glycogen phosphorylase. Furthermore, PHKG2 has a potential role in regulating testicular glycogenolysis. PHKG2 Protein, Human (Sf9, GST) is the recombinant human-derived PHKG2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of PHKG2 Protein, Human (Sf9, GST) is 405 a.a., .


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Talazoparib-13C,d4
Talazoparib- ¹³C,d4 is ¹³C and deuterated labeled Talazoparib (HY-16106). Talazoparib is an orally active PARP 1/2 inhibitor with Ki values of 1.2 nM and 0.87 nM for inhibiting PARP1 and PARP2 enzymatic activities, respectively. Has anti-tumor activity.

Cat. No.	Product Name	Application	Reactivity

HY-P83511

SV40 T Antigen Antibody (YA3256)

Large T antigen; LT; LT-AG
WB, ICC/IF, IP All
HY-P83589

Lymphotoxin alpha Antibody (YA3334)

LTalpha; DIF; LT alpha; LTa; Lymphotoxin alpha; TNF B; TNF superfamily member 1; TNF-beta; TNFB; TNFbeta; TNFSF1; TNLG1E
WB Human

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LT

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

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Isotope-Labeled Compounds

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