1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. (8R,9S)-Talazoparib

(8R,9S)-Talazoparib (Synonyms: (8R,9S)-BMN-673; (8R,9S)-LT-673)

Cat. No.: HY-16106A Purity: 95.08%
Handling Instructions

(8R,9S)-Talazoparib ((8R,9S)-BMN-673) is an enantiomer of Talazoparib, less active than Talazoparib on the inhibition of PARP1, with an IC50 of 144 nM.

For research use only. We do not sell to patients.

(8R,9S)-Talazoparib Chemical Structure

(8R,9S)-Talazoparib Chemical Structure

CAS No. : 1207456-00-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 293 In-stock
Estimated Time of Arrival: December 31
1 mg USD 280 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Description

(8R,9S)-Talazoparib ((8R,9S)-BMN-673) is an enantiomer of Talazoparib, less active than Talazoparib on the inhibition of PARP1, with an IC50 of 144 nM.

IC50 & Target[1]

PARP-1

144 nM (IC50)

Molecular Weight

380.35

Formula

C₁₉H₁₄F₂N₆O

CAS No.

1207456-00-5

SMILES

O=C1NN=C2C3=C1C=C(F)C=C3N[[email protected]@H](C4=CC=C(F)C=C4)[[email protected]@H]2C5=NC=NN5C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (131.46 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6292 mL 13.1458 mL 26.2916 mL
5 mM 0.5258 mL 2.6292 mL 5.2583 mL
10 mM 0.2629 mL 1.3146 mL 2.6292 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(8R,9S)-Talazoparib(8R,9S)-BMN-673(8R,9S)-LT-673PARPpoly ADP ribose polymeraseInhibitorinhibitorinhibit

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Product name:
(8R,9S)-Talazoparib
Cat. No.:
HY-16106A
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