2. GPCR/G Protein
  3. Leukotriene Receptor
  4. BAY-u 9773

BAY-u 9773 is a selective cysteinyl-leukotriene receptor antagonist. BAY-u 9773 competitively antagonizes cysteinyl-leukotriene-induced contractions at typical and atypical cysteinyl-leukotriene receptors with comparable activity. BAY-u 9773 can be used for the research of trichomoniasis.

For research use only. We do not sell to patients.

BAY-u 9773

BAY-u 9773 Chemical Structure

CAS No. : 154978-38-8

Size Price Stock Quantity
Solution
25 μg (211.58 μM * 250 μL in Ethanol) Get quote 3 - 4 Weeks 4 - 5 weeks 5 - 6 weeks 2 - 3 weeks
Liquid
50 μg Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

BAY-u 9773 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BAY-u 9773

View All Leukotriene Receptor Isoform Specific Products:

View All Isoforms
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • Biological Activity

  • Purity & Documentation

  • References

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Description

BAY-u 9773 is a selective cysteinyl-leukotriene receptor antagonist. BAY-u 9773 competitively antagonizes cysteinyl-leukotriene-induced contractions at typical and atypical cysteinyl-leukotriene receptors with comparable activity. BAY-u 9773 can be used for the research of trichomoniasis[1][2].

IC50 & Target[1]

CysLT1

 

CysLT2

 

Cellular Effect
Cell Line Type Value Description References
CHO IC50
0.44 μM
Compound: BAY-u9773
Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
[PMID: 25408836]
HEK293 IC50
0.3 μM
Compound: BAY-u9773
Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
[PMID: 25408836]
In Vitro

BAY u9773 (10 nM-10 μM; 15 min) competitively displaces [3H] leukotriene D4 binding to guinea-pig lung membranes with a mean pKi of 7.0[1].
BAY-u 9773 (1-10 μM; 30 min pretreatment) dose-dependently inhibits TvSP- and LTC4-induced MCP-1 secretion in HMC-1 cells, with the strongest effect observed at 10 μM[2].
BAY-u 9773 (1-5 μM) dose-dependently inhibits TvSP- and LTC4-induced ROS production in HMC-1 cells, with significant suppression at concentrations ≥1 μM[2].
BAY-u 9773 (5 μM) inhibits TvSP- and LTC4-induced migration of HMC-1 cells by approximately 60%[2].
BAY-u 9773 (1-5 μM) dose-dependently inhibits TvSP- and LTC4-induced degranulation (measured via CD63 expression) in HMC-1 cells, with the strongest effect at 5 μM[2].
BAY-u 9773 inhibits TvSP-induced p47phox phosphorylation in HMC-1 cells[2].
BAY-u 9773 inhibits TvSP- and LTC4-induced NF-κB phosphorylation in HMC-1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY-u 9773 Related Antibodies

ELISA Assay[2]

Cell Line: HMC-1
Concentration: 1 μM; 3 μM; 10 μM
Incubation Time: 30 min pretreatment
Result: Dose-dependently inhibited TvSP-induced MCP-1 secretion, reducing levels to ~260 pg/mL at 10 μM compared to ~460 pg/mL in untreated TvSP-stimulated cells.
Dose-dependently inhibited LTC4-induced MCP-1 secretion, reducing levels to ~270 pg/mL at 10 μM compared to ~460 pg/mL in untreated LTC4-stimulated cells.
In Vivo

BAY-u 9773 (i.v.) induces dose-related bronchoconstriction in anaesthetized guinea-pigs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

472.64

Formula

C27H36O5S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

OC(CCC[C@H](O)[C@@H](/C=C/C=C/C=C\C/C=C\CCCCC)SC1=CC=C(C=C1)C(O)=O)=O
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light
Purity & Documentation

Purity: 95.5%

SDS (393 KB)

COA (242 KB)

Handling Instructions (2659 KB)
References
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BAY-u 9773 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-u 9773154978-38-8Leukotriene ReceptorMCP-1trichomoniasisleukotriene D4leukotriene C4HMC-1 cellscysteinyl-leukotriene receptor antagonistguinea-pig lung homogenateguinea-pigNF-κBcysteinyl-leukotriene receptorsInhibitorinhibitorinhibit

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HY-107609
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