LT-630
LT-630 is a HDAC6 inhibitor. LT-630 ameliorates liver injury by reducing oxidative damage.
For research use only. We do not sell to patients.
- Formula: C19H17FN4O3
- Molecular Weight:368.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC6 |
LT-630 (2-8 nM, 3 h and 24 h) inhibits Acetaminophen (HY-66005)-induced cell damage, reduces the increased oxidative stress and apoptosis in AML-12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AML-12 cells
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Concentration:2-8 nM
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Incubation Time:3 h and 24 h
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Result:Reduced the increased ratio of bax/bcl-2 and the levels of cleaved caspase3 and cyt-c.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:male C57BL/6J mice (16–20 g, 6-week-old)[1]
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Dosage:10-40 mg/kg befor APAP (350 mg/kg, i.p.)
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Administration:tail vein injection
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Result:Enhanced the release of GSH, SOD and NADPH.
Reduced apoptosis, the bax/bcl-2 ratio, and the levels of cleaved caspase3 and cyt-c in APAP.
Chemical Information
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Molecular Weight 368.36
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Formula C19H17FN4O3
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SMILES
O=C(NO)C1=CC=C(CN2N=C(C(NC3=CC(F)=CC=C3)=O)C=C2C)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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