ABMA 

ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity^[1][2].

ABMA protects cells against four bacterial toxins (Corynebacterium diphtheriae (DT; EC₅₀ of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC₅₀ of 73.3?μM),? Clostridium sordellii lethal toxin (TcsL; EC₅₀ of 86.7 μM)), three viruses (Ebola (EC₅₀ of 3.3?μM), rabies (EC₅₀ of 19.4?μM), dengue-4 virus ( EC₅₀ of 8.2?μM)), two species of Chlamydiales intracellular bacteria (Simkania negevensis and Chlamydia trachomatis), and the parasite Leishmania infantum (EC₅₀ of 7.1?μM) at micromolar level^[1].
? In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC₅₀ of 3.8?μM, and a protection factor (R) at 30?μM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD₉₀ of ricin^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

350.29

Solid

C₁₈H₂₄BrNO

332108-65-3

COC1=CC=C(Br)C=C1CNC2(C3)CC4CC3CC(C4)C2

Room temperature in continental US; may vary elsewhere.

• [1]. Wu Y, et al. ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments.  [Content Brief]

  [2]. Wu Y, et al. DABMA: A Derivative of ABMA with Improved Broad-Spectrum Inhibitory Activity of Toxins and Viruses. ACS Med Chem Lett. 2019 Jul 2;10(8):1140-1147.  [Content Brief]