1. Anti-infection
  2. Bacterial
    Influenza Virus
    Parasite
  3. ABMA

ABMA 

Cat. No.: HY-124801 Purity: 99.61%
Handling Instructions

ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity.

For research use only. We do not sell to patients.

ABMA Chemical Structure

ABMA Chemical Structure

CAS No. : 332108-65-3

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 380 In-stock
Estimated Time of Arrival: December 31
100 mg USD 580 In-stock
Estimated Time of Arrival: December 31
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Description

ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens. ABMA efficiently protects cells against various toxins and pathogens including viruses, intracellular bacteria and parasite. ABMA selectively acts at host cell late endosomes rather than targeting toxin or pathogen itself. ABMA has broad-spectrum anti-infection activity[1][2].

IC50 & Target

Intracellular bacteria[1]
Viruses[1]
Parasite[1]

In Vitro

ABMA protects cells against four bacterial toxins (Corynebacterium diphtheriae (DT; EC50 of 62.9 μM), Bacillus anthracis (LT), Clostridium difficile toxin B (TcdB; EC50 of 73.3 µM), Clostridium sordellii lethal toxin (TcsL; EC50 of 86.7 μM)), three viruses (Ebola (EC50 of 3.3 µM), rabies (EC50 of 19.4 µM), dengue-4 virus ( EC50 of 8.2 µM)), two species of Chlamydiales intracellular bacteria (Simkania negevensis and Chlamydia trachomatis), and the parasite Leishmania infantum (EC50 of 7.1 µM) at micromolar level[1].
In A549 cells, ABMA treatment induces a decrease in ricin cytotoxicity with an EC50 of 3.8 µM, and a protection factor (R) at 30 µM ranging from 5 to 10. ABMA retained almost 100% of its biological activity against ricin-induced cytotoxicity up to six days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ABMA (2-200 mg/kg; intraperitoneal injection; female BALB/c mice) treatment protects mice from nasal instillation of an LD90 of ricin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogen-free female BALB/c mice (6 week-old) with ricin[1]
Dosage: 2 mg/kg, 20 mg/kg, 200 mg/kg
Administration: Intraperitoneal injection
Result: A statistically significant protection according to survival curves was observed with a single ip dose of 2 mg/kg. The 20 mg/kg dose fully protected animals through to day 21. The 200 mg/kg dose resulted in 80% of protection of mice against ricin challenge with a single animal succumbing on day 15.
Molecular Weight

350.29

Formula

C₁₈H₂₄BrNO

CAS No.

332108-65-3

SMILES

COC1=CC=C(Br)C=C1CNC2(C3)CC4CC3CC(C4)C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (356.85 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8548 mL 14.2739 mL 28.5478 mL
5 mM 0.5710 mL 2.8548 mL 5.7096 mL
10 mM 0.2855 mL 1.4274 mL 2.8548 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (17.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (17.84 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (17.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ABMABacterialInfluenza VirusParasiteEndosomestoxinspathogensanti-infectiondiphtheriaricincytotoxicitySnCtrDTLTTcdBTcsLInhibitorinhibitorinhibit

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