1. Protein Tyrosine Kinase/RTK
  2. FLT3
  3. LT-540-717

LT-540-717 (compound 32) is a potent FLT3 inhibitor (IC50=0.62 nM) with antiproliferative activity. LT-540-717 also inhibits several acquired FLT3 mutations, FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V). LT-540-717 has potential to be an anti-AML agent.

For research use only. We do not sell to patients.

LT-540-717 Chemical Structure

LT-540-717 Chemical Structure

CAS No. : 2143089-35-2

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Description

LT-540-717 (compound 32) is a potent FLT3 inhibitor (IC50=0.62 nM) with antiproliferative activity. LT-540-717 also inhibits several acquired FLT3 mutations, FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3 (D835Y) and FLT3 (D835V). LT-540-717 has potential to be an anti-AML agent[1].

Molecular Weight

456.50

Formula

C24H24N8O2

CAS No.
SMILES

O=C(NC1=CC=C(N2CCNCC2)C=C1)C3=NNC=C3NC4=NC=NC(OC5=CC=CC=C5)=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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LT-540-717 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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LT-540-717
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HY-155594
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