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Neu5Acα2-6Galβ1-4GlcNAc

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By Targets:	ADC Linker (1) Bacterial (1) Biochemical Assay Reagents (7) Endogenous Metabolite (9) Fluorescent Dye (1) Fructose-1,6-bisphosphate aldolase (2) Glycosidase (1) Influenza Virus (1) Potassium Channel (1) Ser/Thr Protease (1) Sialyltransferase (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Endocrinology (1) Infection (2) Inflammation/Immunology (1) Metabolic Disease (8)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (1)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

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Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110288

3FAx-Neu5Ac 3 Publications Verification	Sialyltransferase	Metabolic Disease
3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X .

HY-112942A

CMP-Sialic acid sodium salt 4 Publications Verification CMP-Neu5Ac sodium salt	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of *UDP-GlcNAc* 2-epimerase**. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-125798

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid 4 Publications Verification Neu5Ac2en; DANA	Influenza Virus	Infection
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC₅₀s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity .

HY-W145561

Neu5Acα(2-3)Galβ MP glycoside Neu5Ac alpha(2-3)Gal beta MP glycoside	Biochemical Assay Reagents	Others
Neu5Acα(2-3)Galβ MP glycoside (Neu5Ac alpha(2-3)Gal beta MP glycoside) is a glycoside used in glycobiology research to explore cell surface interactions and signal transduction pathways.

HY-112942

CMP-Sialic acid CMP-Neu5Ac	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of *UDP-GlcNAc* 2-epimerase**. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-32264

*X-Neu5Ac* sodium** X-NeuNAc	Bacterial	Others
X-Neu5Ac (sodium) is a substrate for chromogenic assay of neuraminidase activity in bacterial expression systems; with a K_m of 0.89 mM for neuraminidase.

HY-151852

9AzNue5Ac	Endogenous Metabolite	Cardiovascular Disease
9AzNue5Ac, 9-azido-9-deoxy-N-acetylneuraminic acid, is a click chemistry reagent and a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide. 9AzNue5Ac could be metabolized and incorporated into sialoglycans in living cells and mice. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-160821A

N-Acetylmannosamine 6-phosphate sodium salt ManNAc-6P sodium salt	Endogenous Metabolite	Others
N-Acetylmannosamine 6-phosphate sodium salt is a NanR modulator and an intermediate in the sialic acid pathway. N-Acetylmannosamine 6-phosphate sodium salt disrupts the binding of NanR to the promoter regions of nanAT and nanE, and prevents NanR-mediated transcriptional repression of these loci. N-Acetylmannosamine 6-phosphate sodium salt acts as a key precursor for sialic acid biosynthesis, participating in this process via Neu5Ac-9-P synthase. N-Acetylmannosamine 6-phosphate sodium salt can be used in research related to GNE myopathy .

HY-P2977

N-Acetylneuraminate lyase (CgNal) Sialic acid aldolase (CgNal)	Fructose-1,6-bisphosphate aldolase Endogenous Metabolite	Others
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .

HY-W145622

*Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP* Gal beta(1-3)[Neu5Ac alpha(2-6)]GlcNAc-beta-pNP	Biochemical Assay Reagents	Others
Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-E70052

alpha-1,3-Galactosyltransferase (a1,3GalT) GGTA1	Endogenous Metabolite	Metabolic Disease
alpha-1,3-Galactosyltransferase (a1,3GalT) (GGTA1) catalyzes the generation of the α-gal glycan via the transfer of a galactose (Gal) in α1-3 linkage, from a uridyl-diphosphate (UDP) donor onto the N-acetyllactosamine (Galβ1,4GlcNAc-R) of glycoproteins. alpha-1,3-Galactosyltransferase (a1,3GalT) is responsible for the synthesis of the α-galactose (α-Gal) epitope found in most mammalian species .

HY-N10628

Neu5Acα(2-6) N-Glycan	Biochemical Assay Reagents	Others
Neu5Acα(2-6) N-Glycan is a N-Glycan, and can be used for labeling and modification of proteins.

HY-D2982

BTP9-Neu5Ac	Fluorescent Dye	Infection
BTP9-Neu5Ac is a fluorescent imaging probe specifically designed for detecting the neuraminidase (NA) sialidase activity of influenza viruses. BTP9-Neu5Ac can visualize the intracellular Golgi localization of the viral NA activity. BTP9-Neu5Ac can be used for precise and temporal monitoring of the key enzyme activities during the viral life cycle .

HY-171289

Neu5Acα2-6GalNAcα1-4GlcNac	Biochemical Assay Reagents	Others
Neu5Acα2-6GalNAcα1-4GlcNac is the derivative of Neu5Acα2-6GalNAcα. Neu5Acα2-6GalNAcα can be used for synthesis of glycopolymer .

HY-E70621

Sialic acid aldolase (Pm NaNa)	Biochemical Assay Reagents Fructose-1,6-bisphosphate aldolase	Metabolic Disease
Sialic acid aldolase (Pm NaNa) (EC 4.1.3.3) is a type I aldolase that catalyze the reversible aldol cleavage of N-acetylneuraminic acid (Neu5Ac) to form pyruvate and N-acetyl-D-mannosamine (ManNAc) with the equilibrium favoring the Neu5Ac cleavage .

HY-W145540

Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP	Biochemical Assay Reagents	Others
Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-180467

Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me	ADC Linker	Cancer
Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me (Compound G12) is a disaccharide linker. Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me can be efficiently recognized by the endo-glycosidase Endo-S2 and can be directedly transferred to the conserved N-glycosylation site (Asn297 position) of the antibody's Fc domain through enzymatic catalytic reactions, thereby achieving site-specific modification of the antibody. Neu5Ac-2Galβ1-3Glc-oxazoline-(2)Me can be used for for the synthesis of antibody-conjugated drugs (ADCs) .

HY-112942B

CMP-Sialic acid disodium CMP-Neu5Ac disodium	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) sodium is an allosteric inhibitor of *UDP-GlcNAc* 2-epimerase**. CMP-Sialic acid sodium provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-E70019

alpha-2-3,6-sialidase (BiNanH2)	Endogenous Metabolite	Metabolic Disease
alpha-2-3,6-sialidase (BiNanH2) is a sialyltransferase, is often used in biochemical studies. alpha-2-3,6-sialidase (BiNanH2) catalyzes α-2,3/2,6-sialyltransfer from CMP-Neu5Ac to galactoside acceptors .

HY-P2858

β-Mannosidase	Glycosidase	Metabolic Disease
β-Mannosidase is a lysosomal exo‑acting enzyme. β-Mannosidase catalyzes hydrolysis of β‑1,4‑linked mannosides, non‑reducing terminal mannoses in N‑glycoproteins, and Man‑β‑1,4‑GlcNAc linkages to release mannose. β-Mannosidase contributes to glycoprotein catabolism and supports Bifidobacteria colonization via N‑glycan depolymerization. β-Mannosidase can be used for the research of β-mannosidosis and β-mannosidase deficiency .

HY-W145631

*GalNAcβ(1-4)GlcNAc-β-pNP* GalNAc beta(1-4)GlcNAc-beta-pNP	Biochemical Assay Reagents	Others
GalNAcβ(1-4)GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-E70297

N-Acetylglucosaminyltransferase IVa MGAT4A	Endogenous Metabolite	Cancer
N-Acetylglucosaminyltransferase IVa (MGAT4A) is a glycosyltransferase that can enhance the migration, invasion, and adhesion abilities of cancer cells, and increase β1,4GlcNAc branched glycans on integrin β1 (ITGB1), a tumor-associated glycoprotein closely related to cell motility .

HY-P10572

HG1 Toxin	Ser/Thr Protease Potassium Channel	Inflammation/Immunology Endocrinology
HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (K_i=107 nM) and can be used in the study of autoimmune diseases .

Cat. No.	Product Name	Type

HY-32264

*X-Neu5Ac* sodium** X-NeuNAc	Fluorescent Dyes
X-Neu5Ac (sodium) is a substrate for chromogenic assay of neuraminidase activity in bacterial expression systems; with a K_m of 0.89 mM for neuraminidase.

HY-D2982

BTP9-Neu5Ac	Fluorescent Dyes
BTP9-Neu5Ac is a fluorescent imaging probe specifically designed for detecting the neuraminidase (NA) sialidase activity of influenza viruses. BTP9-Neu5Ac can visualize the intracellular Golgi localization of the viral NA activity. BTP9-Neu5Ac can be used for precise and temporal monitoring of the key enzyme activities during the viral life cycle .

Neu5Acα(2-3)Galβ MP glycoside Neu5Ac alpha(2-3)Gal beta MP glycoside	Biochemical Assay Reagents
Neu5Acα(2-3)Galβ MP glycoside (Neu5Ac alpha(2-3)Gal beta MP glycoside) is a glycoside used in glycobiology research to explore cell surface interactions and signal transduction pathways.

*Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP* Gal beta(1-3)[Neu5Ac alpha(2-6)]GlcNAc-beta-pNP	Biochemical Assay Reagents
Galβ(1-3)[Neu5Acα(2-6)]GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP	Biochemical Assay Reagents
Galβ(1-3)[Neu5Acα(2-6)]GalNAc-α-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

*GalNAcβ(1-4)GlcNAc-β-pNP* GalNAc beta(1-4)GlcNAc-beta-pNP	Biochemical Assay Reagents
GalNAcβ(1-4)GlcNAc-β-pNP is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Target	Research Area

HY-P4752

*KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2*	Peptides	Others
KWKHGAEIVYKSPVV-{S(GlcNAc-β-D)}-GDTSPRHLSNVK-{K(biotinyl)}-NH2 is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P5747

Glycocin F	Peptides	Others
Glycocin F is a antimicrobial peptide with activity against L. plantarum .

HY-P10572

HG1 Toxin	Ser/Thr Protease Potassium Channel	Inflammation/Immunology Endocrinology
HG1 Toxin is a peptide found in the venom of the scorpion Heterometrus fulvipes, which has the activity of inhibiting potassium channel Kv1.3. HG1 Toxin also has the activity of inhibiting trypsin (K_i=107 nM) and can be used in the study of autoimmune diseases .

CMP-Sialic acid sodium salt 4 Publications Verification CMP-Neu5Ac sodium salt	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of *UDP-GlcNAc* 2-epimerase**. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

CMP-Sialic acid CMP-Neu5Ac	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of *UDP-GlcNAc* 2-epimerase**. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

9AzNue5Ac	Cardiovascular Disease Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
9AzNue5Ac, 9-azido-9-deoxy-N-acetylneuraminic acid, is a click chemistry reagent and a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide. 9AzNue5Ac could be metabolized and incorporated into sialoglycans in living cells and mice. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Neu5Acα(2-6) N-Glycan	Structural Classification Polysaccharides Animals Saccharides Source Classification	Biochemical Assay Reagents
Neu5Acα(2-6) N-Glycan is a N-Glycan, and can be used for labeling and modification of proteins.

Cat. No.	Product Name		Classification

HY-151852

9AzNue5Ac		Azide Labeling and Fluorescence Imaging
9AzNue5Ac, 9-azido-9-deoxy-N-acetylneuraminic acid, is a click chemistry reagent and a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide. 9AzNue5Ac could be metabolized and incorporated into sialoglycans in living cells and mice. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

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Neu5Acα2-6Galβ1-4GlcNAc

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

NaturalProducts

Click Chemistry

Natural
Products