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Cat. No.: HY-112942B

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CMP-Sialic acid disodium

(Synonyms: CMP-Neu5Ac disodium)

CMP-Sialic acid (CMP-Neu5Ac) sodium is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates.

For research use only. We do not sell to patients.

CAS No.: 149007-28-3
Formula: C₂₀H₂₉N₄Na₂O₁₆P
Molecular Weight:658.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CMP-Sialic acid disodium Chemical Structure

CAS No.: 149007-28-3

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Biological Activity
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Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

CMP-Sialic acid (22.5 μM, 45 min) sodium can be used as a CMAH substrate to detect the formation of Neu5Gc in platelet lysates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 149007-28-3
Molecular Weight 658.41
Formula C₂₀H₂₉N₄Na₂O₁₆P
SMILES

O=P(O[C@@](C[C@@H]([C@H]1NC(C)=O)O)(O[C@]1([C@@H]([C@@H](CO)O)O)[H])C(O[Na])=O)(O[Na])OC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=C(N)C=C3)=O)O2
Synonyms

CMP-Neu5Ac disodium
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5. [Content Brief]

[2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.

[3]. Mercado CP, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30;3:2795. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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CMP-Sialic acid disodium

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CMP-Sialic acid disodium Related Classifications

HY-112942B Related Classifications