1. Anti-infection
  2. Influenza Virus
  3. 2,3-Dehydro-2-deoxy-N-acetylneuraminic acid

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid (Synonyms: Neu5Ac2en; DANA)

Cat. No.: HY-125798
Handling Instructions

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity.

For research use only. We do not sell to patients.

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid Chemical Structure

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid Chemical Structure

CAS No. : 24967-27-9

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Description

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity[1][2].

In Vitro

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10-100 μM) signifcantly inhibits sialidase activity in INS-1D cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10 mg/kg; i.p.; daily) attenuates pulmonary fibrosis in a mouse model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (Mouse model of pulmonary fibrosis)[3]
Dosage: 10 mg/kg
Administration: I.p.; daily (starting at day 10 after Bleomycin, and then euthanized at day 21)
Result: Inhibition of sialidases starting at day 10 after bleomycin attenuates fibrosis.
Molecular Weight

291.25

Formula

C₁₁H₁₇NO₈

CAS No.
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Product Name:
2,3-Dehydro-2-deoxy-N-acetylneuraminic acid
Cat. No.:
HY-125798
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