2. Anti-infection
  3. Influenza Virus
  4. 2,3-Dehydro-2-deoxy-N-acetylneuraminic acid

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid  (Synonyms: Neu5Ac2en; DANA)

Cat. No.: HY-125798 Purity: ≥95.0%
COA Handling Instructions

Molarity Calculator

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity.

For research use only. We do not sell to patients.

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid Chemical Structure

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid Chemical Structure

CAS No. : 24967-27-9

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1 mg USD 80 In-stock
5 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 2,3-Dehydro-2-deoxy-N-acetylneuraminic acid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity[1][2].

In Vitro

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10-100 μM) signifcantly inhibits sialidase activity in INS-1D cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid Related Antibodies
In Vivo

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10 mg/kg; i.p.; daily) attenuates pulmonary fibrosis in a mouse model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (Mouse model of pulmonary fibrosis)[3]
Dosage: 10 mg/kg
Administration: I.p.; daily (starting at day 10 after Bleomycin, and then euthanized at day 21)
Result: Inhibition of sialidases starting at day 10 after bleomycin attenuates fibrosis.
Clinical Trial
Molecular Weight

291.25

Formula

C11H17NO8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=C[C@H](O)[C@@H](NC(C)=O)[C@@]([C@H](O)[C@H](O)CO)([H])O1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (114.44 mM; Need ultrasonic)

DMSO : 1 mg/mL (3.43 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4335 mL 17.1674 mL 34.3348 mL
5 mM 0.6867 mL 3.4335 mL 6.8670 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥99.0%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.4335 mL 17.1674 mL 34.3348 mL 85.8369 mL
H2O 5 mM 0.6867 mL 3.4335 mL 6.8670 mL 17.1674 mL
10 mM 0.3433 mL 1.7167 mL 3.4335 mL 8.5837 mL
15 mM 0.2289 mL 1.1445 mL 2.2890 mL 5.7225 mL
20 mM 0.1717 mL 0.8584 mL 1.7167 mL 4.2918 mL
25 mM 0.1373 mL 0.6867 mL 1.3734 mL 3.4335 mL
30 mM 0.1144 mL 0.5722 mL 1.1445 mL 2.8612 mL
40 mM 0.0858 mL 0.4292 mL 0.8584 mL 2.1459 mL
50 mM 0.0687 mL 0.3433 mL 0.6867 mL 1.7167 mL
60 mM 0.0572 mL 0.2861 mL 0.5722 mL 1.4306 mL
80 mM 0.0429 mL 0.2146 mL 0.4292 mL 1.0730 mL
100 mM 0.0343 mL 0.1717 mL 0.3433 mL 0.8584 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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2,3-Dehydro-2-deoxy-N-acetylneuraminic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,3-Dehydro-2-deoxy-N-acetylneuraminic acid24967-27-9Neu5Ac2en DANAInfluenza VirusneuraminidaseenzymespulmonaryfibrosisinsulinsecretionInhibitorinhibitorinhibit

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2,3-Dehydro-2-deoxy-N-acetylneuraminic acid
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