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OGT inhibitor

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By Targets:	OGT (12) Acyltransferase (6) Akt (1) Apoptosis (1) Asialoglycoprotein Receptor (ASGPR) (1) Glucosylceramide Synthase (GCS) (1) Glycosidase (2) GSK-3 (1) MDM-2/p53 (1) mTOR (1) Nucleoside Antimetabolite/Analog (1) PARP (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1)
By Research Areas:	Cancer (5) Inflammation/Immunology (1) Metabolic Disease (8)

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Targets Recommended: OGT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119738

OSMI-1 Maximum Cited Publications 42 Publications Verification	OGT Acyltransferase	Metabolic Disease
OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC₅₀ value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .

HY-114361

OSMI-4 25+ Cited Publications	OGT Acyltransferase	Metabolic Disease
OSMI-4 is a low nanomolar O-GlcNAc transferase *(OGT)* inhibitor, with an EC₅₀ of 3 μM in cells.

HY-100898

OGT 2115 5 Publications Verification	Glycosidase	Cancer
OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC₅₀ of 0.4 μM. OGT 2115 has anti-angiogenic properties (IC₅₀ of 1 μM). OGT 2115 also inhibits heparan sulfate degradation activity .

HY-136282

ST045849 OGT-IN-2	Acyltransferase OGT	Metabolic Disease
ST045849 (OGT-IN-2) is a small-molecule *OGT* inhibitor with an IC₅₀ of 30 μM against sOGT and 53 μM against ncOGT. ST045849 is applicable to research on metabolism-related diseases .

HY-N3677

Dammarenediol II	OGT Akt mTOR GSK-3 Reactive Oxygen Species (ROS) Apoptosis PARP MDM-2/p53	Inflammation/Immunology Cancer
Dammarenediol II is a ginsenoside precursor . Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy .

HY-135784

OSMI-2 1 Publications Verification	OGT Acyltransferase	Metabolic Disease
OSMI-2 (Compound 1b) is a cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced *OGT* transcript, and OSMI-2 increases detained intron splicing in cells .

HY-148113

PG 34	OGT	Others
PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC₅₀=68 μM), and a close structural analog of OSMI-1 (HY-119738) .

HY-129411

Sinbaglustat ACT-519276; OGT2378	Glucosylceramide Synthase (GCS)	Metabolic Disease
Sinbaglustat (OGT2378) is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). Sinbaglustat is an orally available N-alkyl iminosugar that crosses the blood-brain barrier. Sinbaglustat can be used for the research of central neurodegenerative diseases associated with lysosomal dysfunctions .

HY-101548

OGT-IN-1	OGT	Metabolic Disease
OGT-IN-1 (Compound 5) is a potent *OGT* inhibitor. OGT-IN-1 inhibits sOGT and ncOGT with IC₅₀s of 27 and 10 μM, respectively .

HY-149552

Ac4-5SGlcNAc	OGT	Cancer
Ac4-5SGlcNAc is an O-GlcNAc transferase (OGT) inhibitor. Ac4-5SGlcNAc converts intracellularly to UDP-5SGlcNAc, which competes with native UDP-GlcNAc (HY-148596) to block *OGT* catalytic activity, reduces cellular UDP-GlcNAc pools, and limits global protein O-GlcNAcylation. Ac4-5SGlcNAc reduces OGA levels via feedback, alters lectin signal intensities and glycan-related band masses. Ac4-5SGlcNAc can be used for the research of breast cancer .

HY-125278

OGT-IN-4	OGT	Others
OGT-IN-4 (compound 4a) is an O-GlcNAc transferase (OGT) inhibitor with a K_d of 8 nM. OGT-IN-4 can be utilized in OGT related research .

HY-119738A

(Rac)-OSMI-1	OGT Acyltransferase	Metabolic Disease
(Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC₅₀ value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .

HY-135785

OSMI-3	OGT Acyltransferase	Metabolic Disease
OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced *OGT* transcript, and OSMI-3 increases detained intron splicing in cells .

HY-19272

OGT-719	Nucleoside Antimetabolite/Analog Asialoglycoprotein Receptor (ASGPR)	Cancer
OGT-719 is a potent, orally active nucleoside analogue that targets the asialoglycoprotein receptor (ASGP-R). OGT-719 inhibits growth of metastatic colorectal tumors in the liver of nude mice. OGT-719 can be used for primary hepatocellular carcinoma and colorectal liver metastases research .

HY-100898R

OGT 2115 (Standard)	Glycosidase Reference Standards	Cancer
OGT 2115 (Standard) is the analytical standard of OGT 2115 (HY-100898). This product is intended for research and analytical applications. OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC50 of 0.4 μM. OGT 2115 has anti-angiogenic properties (IC50 of 1 μM). OGT 2115 also inhibits heparan sulfate degradation activity .

HY-W477597

BZX2	OGT	Others
BZX2 is an irreversible covalent inhibitor of O-GlcNAc transferase (OGT) with an IC₅₀ of <10 µM. BZX2 is cell-permeable but exhibits multiple off-target effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3677

Dammarenediol II	Triterpenes Structural Classification other families Boswellia freerana Terpenoids Plants Source Classification	OGT Akt mTOR GSK-3 Reactive Oxygen Species (ROS) Apoptosis PARP MDM-2/p53
Dammarenediol II is a ginsenoside precursor . Dammarenediol II reduces the activity of O-GlcNAc transferase (OGT) and downregulates the global O-GlcNAcylation level. Dammarenediol II inhibits the phosphorylation of Akt, mTOR and GSK3β. Dammarenediol II inhibits human carboxylesterase activity, VEGF-induced ROS production, stress fiber formation and vascular endothelial cadherin disruption. Dammarenediol II promotes cell apoptosis (apoptosis), increases the levels of cleaved PARP1 and p53, and inhibits retinal microvascular leakage. Dammarenediol II can be used in studies related to liver cancer and diabetic retinopathy .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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OGT inhibitor

Inhibitors & Agonists

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