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OGT 2115 

Cat. No.: HY-100898 Purity: 99.62%
Handling Instructions

OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC50 of 0.4 μM. OGT 2115 has anti-angiogenic properties (IC50 of 1 μM). OGT 2115 also inhibits heparan sulfate degradation activity.

For research use only. We do not sell to patients.

OGT 2115 Chemical Structure

OGT 2115 Chemical Structure

CAS No. : 853929-59-6

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25 mg USD 300 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC50 of 0.4 μM. OGT 2115 has anti-angiogenic properties (IC50 of 1 μM). OGT 2115 also inhibits heparan sulfate degradation activity[1][2].

IC50 & Target

IC50: 0.4 μM (Heparanase)[1]

In Vitro

Heparanase InhibitorOGT 2115 can suppress metastasis induced by endoplasmic reticulum (ER) stress in breast cancer cells, although not significantly. However, compared with the control group, the number and rate of migrated cells are significantly reduced following the exposure of the cells to Tunicamycin + OGT 2115. OGT 2115 significantly inhibits the invasion and migration induced by Adriamycin. Furthermore, the MTT assay results show that OGT 2115 does not decrease the anti-proliferative effect of Adriamycin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

When administered to mice, OGT 2115 (Compound 12d) shows a plasma concentration of ~10x the heparanase IC50 following oral dosing at 20 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

495.30

Formula

C₂₄H₁₆BrFN₂O₄

CAS No.

853929-59-6

SMILES

O=C(O)CC1=CC=C(OC(C2=CC=C(NC(/C=C/C3=CC=C(Br)C=C3)=O)C(F)=C2)=N4)C4=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 11.36 mg/mL (22.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0190 mL 10.0949 mL 20.1898 mL
5 mM 0.4038 mL 2.0190 mL 4.0380 mL
10 mM 0.2019 mL 1.0095 mL 2.0190 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.14 mg/mL (2.30 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.62%

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Keywords:

OGT 2115OGT2115OGT-2115OthersHeparanaseinvasionmetastasisbasementmembraneextracellularmatrixanti-angiogenicERstressInhibitorinhibitorinhibit

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OGT 2115
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