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Results for "

Opa

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

5

Recombinant Proteins

12

Antibodies

1

Click Chemistry

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-160421
    TREM2-IN-1

    		Apoptosis Inflammation/Immunology Cancer
    TREM2-IN-1 (OPA) is a TREM2 inhibitor derived from oxaliplatin and artesunate. TREM2-IN-1 can relieves immunosuppressive tumor microenvironment and enhancing chemical anticancer efficiency. TREM2-IN-1 deters the tumor growth in mice models bearing MC38 colorectal tumor by reducing the number of CD206 + and CX3CR1 + immunosuppressive macrophages. TREM2-IN-1 also promotes the expansion and infiltration of immunostimulatory dendritic, cytotoxic T and natural killer cells .
    TREM2-IN-1
  • HY-109085
    Difamilast
    3 Publications Verification

    Opa-15406

    		 Phosphodiesterase (PDE) Neurological Disease Inflammation/Immunology Cancer
    Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD) .
    Difamilast
  • HY-158162
    SIRT3 activator 1
    1 Publications Verification

    		 Sirtuin Cardiovascular Disease
    SIRT3 activator 1 (Compound 5v) is a SIRT3 activator. SIRT3 activator 1 selectively elevates SIRT3 expression, leading to the upregulation of SOD2 and OPA1 expression, effectively preventing mitochondrial dysfunction, mitigating oxidative stress, and preserving cardiomyocyte viability. SIRT3 activator 1 can be used for research of cardiovascular diseases .
    SIRT3 activator 1
  • HY-RS16968
    Opa1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Opa1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Opa1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Opa1 Mouse Pre-designed siRNA Set A
    Opa1 Mouse Pre-designed siRNA Set A
  • HY-RS09789
    OPA1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    OPA1 Human Pre-designed siRNA Set A contains three designed siRNAs for OPA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    OPA1 Human Pre-designed siRNA Set A
    OPA1 Human Pre-designed siRNA Set A
  • HY-177306
    Opitor-0

    		Dynamin Cancer
    Opitor-0 is a potent and selective inhibitor of mitochondrial dynamin-related protein Optic Atrophy 1 (OPA1) guanosine triphosphatase (GTPase) with an IC50 of 3 μM. Opitor-0 can induce fragmentation of mitochondria and remodeling of cristae, disrupt the stability of OPA1 oligomers, and significantly enhance the release of cytochrome c and induce apoptosis. Opitor-0 has a synergistic antitumor effect with Bcl-2 inhibitors, such as ABT-737 (HY-50907) and Venetoclax (HY-15531). Opitor-0 can be used for the research of malignant tumors that are resistant to Bcl-2 inhibitors, such as triple-negative breast cancer (TNBC) .
    Opitor-0
  • HY-109085R
    Difamilast (Standard)

    Opa-15406 (Standard)

    		 Reference Standards Phosphodiesterase (PDE) Inflammation/Immunology
    Difamilast (Standard) is the analytical standard of Difamilast. This product is intended for research and analytical applications. Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD) .
    Difamilast (Standard)
  • HY-131037
    MB-0223

    		Dynamin Cancer
    MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM) .
    MB-0223
  • HY-RS09790
    OPA3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    OPA3 Human Pre-designed siRNA Set A contains three designed siRNAs for OPA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    OPA3 Human Pre-designed siRNA Set A
    OPA3 Human Pre-designed siRNA Set A
  • HY-158160
    LBA-3

    		Sodium Channel Metabolic Disease
    LBA-3 is a selective, orally active inhibitor for sodium-coupled citrate transporter SLC13A5, with an IC50 of 67 nM. LBA-3 decreases levels of triglyceride and total cholesterol in oleic and palmitic acid (OPA)-stimulated AML12 cells, PCN-stimulated primary mouse hepatocytes and in mouse models, without detectable toxicity. LBA-3 is blood-brain barrier permeable .
    LBA-3
  • HY-186189
    OPA-S-S-alkyne

    		Biochemical Assay Reagents Infection Cancer
    OPA-S-S-alkyne is a cell surface protein-selective labeling agent. OPA-S-S-alkyne selectively labels hyper-reactive extracellular lysines including ROR2 K382 and ENG K285, blocks ENG-BMP9 interaction, and labels purified human serum albumin with minimal bias. OPA-S-S-alkyne can be used for the research of hematologic and influenza A virus infection .
    OPA-S-S-alkyne
  • HY-RS23411
    Opa1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Opa1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Opa1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Opa1 Rat Pre-designed siRNA Set A
    Opa1 Rat Pre-designed siRNA Set A
  • HY-180786
    DdBIC

    		Nuclear Hormone Receptor 4A/NR4A Pyroptosis Reactive Oxygen Species (ROS) PERK Caspase Cancer
    DdBIC is a pyroptosis inducer. DdBIC binds to Nur77 and triggers its translocation to mitochondria, activates SDHA to deplete succinyl-CoA, disrupts heme homeostasis, induces electron leakage, and elicits mitochondrial ROS production. DdBIC induces mitochondrial ROS that oxidatively activates OMA1, promotes OPA1 cleavage and its release into the cytoplasm, activates the integrated stress response via PERK, and ultimately activates granzyme B to cleave GSDMC. DdBIC can be used for the study of melanoma .
    DdBIC

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