MB-0223
MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM).
For research use only. We do not sell to patients.
- CAS No.: 2247732-89-2
- Formula: C26H27N5OS
- Molecular Weight:457.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 1.3 μM (Drp1)[1]
MB-0223 (30 μM; 48 hours) increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion[1].MB-0223 (0-100 μM) is a partial inhibitor and exhibits a maximum inhibition of 67% of Drp1 activity. MB-0223 exhibits >100-fold selectivity for Drp1 over two other dynamin-like GTPases, Opa1 and Dnm1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2247732-89-2
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Molecular Weight 457.59
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Formula C26H27N5OS
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SMILES
O=C(C1=CC(C)=CN1CC2=CSC(N3CCCCC3)=N2)NC4=CC=C(C5=CC=CN=C5)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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