1. Cytoskeleton
  2. Dynamin
  3. MB-0223

MB-0223 

Cat. No.: HY-131037
Handling Instructions

MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM).

For research use only. We do not sell to patients.

MB-0223 Chemical Structure

MB-0223 Chemical Structure

CAS No. : 2247732-89-2

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Description

MB-0223 is a potent and selective dynamin-related GTPase Drp1 partial inhibitor (IC50=1.3 μM) over other dynamin family members, Opa 1 and dynamin-1 (IC50>100 μM)[1].

IC50 & Target

IC50: 1.3 μM (Drp1)[1]

In Vitro

MB-0223 (30 μM; 48 hours) increases mitochondrial DNA levels in mfn1- knockout MEFs deficient in mitochondrial fusion[1].
MB-0223 (0-100 μM) is a partial inhibitor and exhibits a maximum inhibition of 67% of Drp1 activity. MB-0223 exhibits >100-fold selectivity for Drp1 over two other dynamin-like GTPases, Opa1 and Dnm1[1].

Molecular Weight

457.59

Formula

C₂₆H₂₇N₅OS

CAS No.

2247732-89-2

SMILES

O=C(C1=CC(C)=CN1CC2=CSC(N3CCCCC3)=N2)NC4=CC=C(C5=CC=CN=C5)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

MB-0223MB0223MB 0223DynaminmitochondrialDrp1MEFsfusionGTPasedynamin-relatedInhibitorinhibitorinhibit

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