2. Vitamin D Related/Nuclear Receptor Immunology/Inflammation Apoptosis Metabolic Enzyme/Protease NF-κB Cell Cycle/DNA Damage
  3. Nuclear Hormone Receptor 4A/NR4A Pyroptosis Reactive Oxygen Species (ROS) PERK Caspase
  4. DdBIC

DdBIC is a pyroptosis inducer. DdBIC binds to Nur77 and triggers its translocation to mitochondria, activates SDHA to deplete succinyl-CoA, disrupts heme homeostasis, induces electron leakage, and elicits mitochondrial ROS production. DdBIC induces mitochondrial ROS that oxidatively activates OMA1, promotes OPA1 cleavage and its release into the cytoplasm, activates the integrated stress response via PERK, and ultimately activates granzyme B to cleave GSDMC. DdBIC can be used for the study of melanoma.

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DdBIC

DdBIC Chemical Structure

CAS No. : 3085711-53-8

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DdBIC Related Antibodies

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Nur77/NR4A1 Nurr1/NR4A2

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

DdBIC is a pyroptosis inducer. DdBIC binds to Nur77 and triggers its translocation to mitochondria, activates SDHA to deplete succinyl-CoA, disrupts heme homeostasis, induces electron leakage, and elicits mitochondrial ROS production. DdBIC induces mitochondrial ROS that oxidatively activates OMA1, promotes OPA1 cleavage and its release into the cytoplasm, activates the integrated stress response via PERK, and ultimately activates granzyme B to cleave GSDMC. DdBIC can be used for the study of melanoma[1].

Molecular Weight

330.46

Formula

C20H30N2O2
CAS No.
SMILES

O=C(C1=CC=C2NC=NC2=C1)OCCCCCCCCCCCC
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Room temperature in continental US; may vary elsewhere.
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References
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DdBIC Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DdBIC3085711-53-8Nuclear Hormone Receptor 4A/NR4APyroptosisReactive Oxygen Species (ROS)PERKCaspaseNuclear Hormone Receptor 4ANerve Growth Factor IB-like ReceptorProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseGSDMCNuclear receptor Nur77Heme homeostasisMitochondrial ROSIntegrated stress response (ISR)Granzyme BMelanomaInhibitorinhibitorinhibit

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