3085711-53-8
Chemical Structure
DdBIC
- CAS No.: 3085711-53-8
- Formula:C20H30N2O2
- Molecular Weight:330.46
InChIKey: VXKKXAFRWVJMCS-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2NC=NC2=C1)OCCCCCCCCCCCC
Biological Activity: DdBIC is a pyroptosis inducer. DdBIC binds to Nur77 and triggers its translocation to mitochondria, activates SDHA to deplete succinyl-CoA, disrupts heme homeostasis, induces electron leakage, and elicits mitochondrial ROS production. DdBIC induces mitochondrial ROS that oxidatively activates OMA1, promotes OPA1 cleavage and its release into the cytoplasm, activates the integrated stress response via PERK, and ultimately activates granzyme B to cleave GSDMC. DdBIC can be used for the study of melanoma[1].
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DdBIC | DdBIC is a pyroptosis inducer. DdBIC binds to Nur77 and triggers its translocation to mitochondria, activates SDHA to deplete succinyl-CoA, disrupts heme homeostasis, induces electron leakage, and elicits mitochondrial ROS production. DdBIC induces mitochondrial ROS that oxidatively activates OMA1, promotes OPA1 cleavage and its release into the cytoplasm, activates the integrated stress response via PERK, and ultimately activates granzyme B to cleave GSDMC. DdBIC can be used for the study of melanoma. | |||||||||||||||||||||
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Keywords
