RTN4IP1 Antibody (YA7991)
(Synonyms: NIMP; OPA10)RTN4IP1 Antibody (YA7991) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RTN4IP1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:2000-3000 | 1:150-500 | 1:100 |
Product Details
RTN4IP1 Antibody (YA7991) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RTN4IP1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 38.9 kDa
Full length human recombinant protein of human RTN4IP1 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
RTN4IP1 is a NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway. Required for the O-methyltransferase activity of COQ3. Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro. However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo. May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury[1].
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Subcellular Localization
Mitochondrion matrix,Mitochondrion outer membrane
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Expression
Tissue_Specificity: Widely expressed in mitochondria-enriched tissues (PubMed:12067236). Found in heart, muscle, kidney, liver, brain and placenta (PubMed:12067236) -
Isoforms & Post-Translational Modification
Q8WWV3 has three isomers: Q8WWV3-1: 43590 Da (predicted); Q8WWV3-2: 32235 Da (predicted); Q8WWV3-3: 24936 Da (predicted).
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Subunit
Interacts with RTN4, UQCRC1 and UQCRC2
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SwissProt ID
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Synonyms
NIMP; OPA10
Documentation
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