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Oxidation+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) AMPK (1) Apoptosis (2) Autophagy (4) Biochemical Assay Reagents (2) c-Met/HGFR (1) Calcium Channel (3) Cholinesterase (ChE) (1) DGK (1) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (1) Guanylate Cyclase (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) Mitochondrial Metabolism (6) mTOR (1) NF-κB (1) NO Synthase (2) Oxidative Phosphorylation (1) PI3K (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Sodium Channel (3) Src (1) STAT (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (9) Infection (1) Inflammation/Immunology (2) Metabolic Disease (9) Neurological Disease (4)

By Targets:

Akt (1)

AMPK (1)

Apoptosis (2)

Autophagy (4)

Biochemical Assay Reagents (2)

c-Met/HGFR (1)

Calcium Channel (3)

Cholinesterase (ChE) (1)

DGK (1)

Drug Intermediate (1)

Drug Metabolite (1)

Endogenous Metabolite (1)

Guanylate Cyclase (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (1)

Mitochondrial Metabolism (6)

mTOR (1)

NF-κB (1)

NO Synthase (2)

Oxidative Phosphorylation (1)

PI3K (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (3)

Sodium Channel (3)

Src (1)

STAT (1)

By Research Areas:

Cancer (5)

Cardiovascular Disease (9)

Infection (1)

Inflammation/Immunology (2)

Metabolic Disease (9)

Neurological Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1836

Meldonium 5 Publications Verification MET-88; Quaterin	Mitochondrial Metabolism	Cardiovascular Disease Metabolic Disease
Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Meldonium exhibits IC₅₀ values of 34-62 μM for human recombinant BBOX and an EC₅₀ of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor .

HY-17401

Ranolazine dihydrochloride 4 Publications Verification CVT 303 dihydrochloride; RS 43285	Calcium Channel Sodium Channel Autophagy	Cardiovascular Disease Cancer
Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (I_Na and I_Kr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor .

HY-B1836A

Meldonium dihydrate 5 Publications Verification MET-88 dihydrate; Quaterin dihydrate	Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Metabolic Disease
Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate dihydrate exhibits IC₅₀ values of 34-62 μM for human recombinant BBOX and an EC₅₀ of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor .

HY-B1836R

Meldonium (Standard) MET-88 (Standard); Quaterin (Standard)	Mitochondrial Metabolism Reference Standards	Cardiovascular Disease Metabolic Disease
Meldonium (Standard) is the analytical standard of Meldonium. This product is intended for research and analytical applications. Meldonium (MET-88) functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate (Meldonium) exhibits IC50 values of 34-62 μM for human recombinant BBOX and an EC50 of 21 μM for human OCTN2. Meldonium is a fatty acid oxidation inhibitor .

HY-126221A

(R)-Aminocarnitine Emeriamine	Biochemical Assay Reagents	Metabolic Disease
(R)-Aminocarnitine (Emeriamine) is a fatty acid oxidation inhibitor. (R)-Aminocarnitine reduces hyperglycaemia and ketosis. (R)-Aminocarnitine can be used in the study of metabolic diseases .

HY-114548

Ebselen oxide	Guanylate Cyclase	Infection
Ebselen oxide, the selenone analogue of Ebselen, covalently modifies diguanylate cyclase (DGC) to inhibit c-di-GMP-receptor interactions and reduces DGC activity. Ebselen oxide also inhibits alginate production (IC₅₀=14 μM) by Pseudomonas aeruginosa. Ebselen oxide inhibits HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9 (IC₅₀ ranging from 0.2 to 4.7 μM) .

HY-122949

Momordicine I 2 Publications Verification	Apoptosis Autophagy DGK Mitochondrial Metabolism NO Synthase PI3K Akt Interleukin Related Src AMPK mTOR NF-κB c-Met/HGFR STAT Keap1-Nrf2 Reactive Oxygen Species (ROS) Oxidative Phosphorylation Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Momordicine I is a cucurbitane-type triterpenoids. Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation. Momordicine I inhibits glycolysis, lipid metabolism, induces autophagy in HNC cells to suppress head and neck cancer growth. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ. Momordicine I exerts its cardiovascular benefits by upregulating nitric oxide, inhibiting the activity of angiotensin-converting enzyme (ACE), activating the PI3K/Akt pathway, reducing oxidative stress and inflammation. Momordicine I inhibits AKT1, IL-6, and SRC, suggesting its potential application in type 2 diabetes .

HY-N9376

Kansuinine E	NO Synthase	Inflammation/Immunology
Kansuinine E is a plant-derived nitric oxide inhibitor (IC₅₀=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui .

HY-N2051

Zeylenone	Apoptosis	Cancer
Zeylenone, a naturally occurring cyclohexene oxide, inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways .

HY-17401S

Ranolazine-d8 dihydrochloride CVT 303-d8 dihydrochloride; RS 43285-d8	Calcium Channel Sodium Channel Autophagy	Cardiovascular Disease Cancer
Ranolazine-d₈ (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor .

HY-17401R

Ranolazine dihydrochloride (Standard) CVT 303 dihydrochloride (Standard); RS 43285 (Standard)	Calcium Channel Sodium Channel Autophagy Reference Standards	Cardiovascular Disease Cancer
Ranolazine (dihydrochloride) (Standard) is the analytical standard of Ranolazine (dihydrochloride). This product is intended for research and analytical applications. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor .

HY-B1836AR

Meldonium dihydrate (Standard) MET-88 dihydrate (Standard); Quaterin dihydrate (Standard)	Reference Standards Mitochondrial Metabolism	Cardiovascular Disease Neurological Disease Metabolic Disease
Meldonium (dihydrate) (Standard) is the analytical standard of Meldonium (dihydrate). This product is intended for research and analytical applications. Meldonium (MET-88) dihydrate functions as a cardioprotective agent by cpmpetetively inhibiting γ-butyrobetaine hydroxylase (BBOX) and carnitine/organic cation transporter type 2 (OCTN2). Mildronate dihydrate exhibits IC₅₀ values of 34-62 μM for human recombinant BBOX and an EC₅₀ of 21 μM for human OCTN2. Meldonium dihydrate is a fatty acid oxidation inhibitor .

HY-126221B

(R)-Aminocarnitine TFA Emeriamine TFA	Biochemical Assay Reagents	Metabolic Disease
(R)-Aminocarnitine (Emeriamine) TFA is a fatty acid oxidation inhibitor that reduces hyperglycemia and ketosis. (R)-Aminocarnitine TFA can be used in the study of metabolic diseases .

HY-N7263

Galanthamine N-Oxide	Cholinesterase (ChE)	Neurological Disease
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .

HY-B1836S

Meldonium-d3 MET-88-d₃; Quaterin-d₃	Isotope-Labeled Compounds Mitochondrial Metabolism	Cardiovascular Disease Metabolic Disease
Meldonium-d3 is the deuterated form of Meldonium. Meldonium is a cardiovascular protective agent that competitively inhibits BBOX1 and OCTN2. The IC₅₀ value of Mildronate against human recombinant BBOX is 34-62 μM, and the EC₅₀ value against human OCTN2 is 21 μM. Meldonium is a fatty acid oxidation inhibitor .

HY-147333

Trimipramine N-oxide	Drug Metabolite	Neurological Disease
Trimipramine N-oxide is an active metabolite of the tricyclic antidepressant trimipramine. Trimipramine N-oxide inhibits the human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT) and the human organic cation transporters (hOCT1 and hOCT2) with IC₅₀s of 11.7, 3.59, 9.4, 9.35 and 27.4 nM, respectively. Trimipramine N-oxide can be used for the research of depression and anxiety .

HY-182438

SDZ 51641	Drug Intermediate	Metabolic Disease
SDZ 51641 is an orally active fatty acid oxidation inhibitor. By reducing fatty acid oxidation, SDZ 51641 deprives the gluconeogenesis process of required energy and cofactors, thereby lowering blood glucose levels in diabetic models. SDZ 51641 can be used in diabetes research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122949

Momordicine I 2 Publications Verification	Triterpenes Terpenoids Cucurbitaceae Plants Momordica charantia Linn. Source Classification	Apoptosis Autophagy DGK Mitochondrial Metabolism NO Synthase PI3K Akt Interleukin Related Src AMPK mTOR NF-κB c-Met/HGFR STAT Keap1-Nrf2 Reactive Oxygen Species (ROS) Oxidative Phosphorylation Endogenous Metabolite
Momordicine I is a cucurbitane-type triterpenoids. Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation. Momordicine I inhibits glycolysis, lipid metabolism, induces autophagy in HNC cells to suppress head and neck cancer growth. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ. Momordicine I exerts its cardiovascular benefits by upregulating nitric oxide, inhibiting the activity of angiotensin-converting enzyme (ACE), activating the PI3K/Akt pathway, reducing oxidative stress and inflammation. Momordicine I inhibits AKT1, IL-6, and SRC, suggesting its potential application in type 2 diabetes .

HY-N9376

Kansuinine E	Classification of Application Fields Terpenoids Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	NO Synthase
Kansuinine E is a plant-derived nitric oxide inhibitor (IC₅₀=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui .

HY-N2051

Zeylenone	Natural Products Classification of Application Fields Uvaria grandiflora Roxb. Plants Annonaceae Disease Research Fields Cancer Source Classification	Apoptosis
Zeylenone, a naturally occurring cyclohexene oxide, inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways .

HY-N7263

Galanthamine N-Oxide	Alkaloids other families Plants Source Classification	Cholinesterase (ChE)
Galanthamine N-Oxide is an alkaloid obtained from the bulbs of Zephyranthes concolor. Galanthamine N-Oxide inhibits electric eel acetylcholinesterase (AChE) with an EC₅₀ of 26.2 μM. Galanthamine N-Oxide is a prominent inhibitor of substrate accommodation in the active site of the Torpedo californica AChE (TcAChE), hAChE and hBChE enzymes .

Cat. No.	Product Name	Chemical Structure

HY-17401S

Ranolazine-d8 dihydrochloride
Ranolazine-d₈ (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor .

Ranolazine-d8 dihydrochloride

Ranolazine-d₈ (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC₅₀ values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor .

HY-B1836S

Meldonium-d3
Meldonium-d3 is the deuterated form of Meldonium. Meldonium is a cardiovascular protective agent that competitively inhibits BBOX1 and OCTN2. The IC₅₀ value of Mildronate against human recombinant BBOX is 34-62 μM, and the EC₅₀ value against human OCTN2 is 21 μM. Meldonium is a fatty acid oxidation inhibitor .

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