1. Membrane Transporter/Ion Channel
    Autophagy
  2. Calcium Channel
    Sodium Channel
    Autophagy
  3. Ranolazine dihydrochloride

Ranolazine dihydrochloride (Synonyms: CVT 303 (dihydrochloride); RS 43285)

Cat. No.: HY-17401 Purity: 99.92%
Handling Instructions

Ranolazine dihydrochloride (RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP).

For research use only. We do not sell to patients.

Ranolazine dihydrochloride Chemical Structure

Ranolazine dihydrochloride Chemical Structure

CAS No. : 95635-56-6

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 92 In-stock
Estimated Time of Arrival: December 31
100 mg USD 84 In-stock
Estimated Time of Arrival: December 31
200 mg USD 132 In-stock
Estimated Time of Arrival: December 31
500 mg USD 192 In-stock
Estimated Time of Arrival: December 31
1 g USD 240 In-stock
Estimated Time of Arrival: December 31
5 g USD 540 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Other Forms of Ranolazine dihydrochloride:

Top Publications Citing Use of Products

    Ranolazine dihydrochloride purchased from MCE. Usage Cited in: Theranostics. 2018 Oct 29;8(19):5452-5468.

    Western Blot analysis of vector or PITPNC1 overexpressing BGC823 and AGS which are seeded and treated with Ranolazine.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Ranolazine dihydrochloride (RS-43285) is an antianginal agent with antiarrhythmic properties that achieves its effects via a novel mechanism of action (inhibition of the late phase of the inward sodium current), without affecting heart rate or blood pressure (BP). IC50 value: Target: sodium-dependent calcium channel Ranolazine is currently approved for use in chronic angina. The basis for this use is likely related to inhibition of late sodium channels with resultant beneficial downstream effects. Randomized clinical trials have demonstrated an improvement in exercise capacity and reduction in angina episodes with ranolazine.

    Clinical Trial
    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (99.91 mM)

    H2O : ≥ 50 mg/mL (99.91 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9982 mL 9.9908 mL 19.9816 mL
    5 mM 0.3996 mL 1.9982 mL 3.9963 mL
    10 mM 0.1998 mL 0.9991 mL 1.9982 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    500.46

    Formula

    C₂₄H₃₅Cl₂N₃O₄

    CAS No.

    95635-56-6

    SMILES

    O=C(NC1=C(C)C=CC=C1C)CN2CCN(CC(O)COC3=CC=CC=C3OC)CC2.[H]Cl.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.92%

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    Ranolazine dihydrochloride
    Cat. No.:
    HY-17401
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    Ranolazine dihydrochloride

    Cat. No.: HY-17401