1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Autophagy
  2. Calcium Channel
    Sodium Channel
    Autophagy
  3. Ranolazine dihydrochloride

Ranolazine dihydrochloride (Synonyms: CVT 303 dihydrochloride; RS 43285)

Cat. No.: HY-17401 Purity: 99.92%
Handling Instructions

Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor.

For research use only. We do not sell to patients.

Ranolazine dihydrochloride Chemical Structure

Ranolazine dihydrochloride Chemical Structure

CAS No. : 95635-56-6

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Ranolazine dihydrochloride:

Top Publications Citing Use of Products

Publications Citing Use of MCE Ranolazine dihydrochloride

    Ranolazine dihydrochloride purchased from MCE. Usage Cited in: Theranostics. 2018 Oct 29;8(19):5452-5468.

    Western Blot analysis of vector or PITPNC1 overexpressing BGC823 and AGS which are seeded and treated with Ranolazine.
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    Description

    Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3].

    IC50 & Target

    IC50: 6 μM (INa), 12 μM (IKr)[1]

    In Vivo

    Ranolazine (Bolus injection 10 mg/kg and infusion 9.6 mg/kg/h; bolus injection; for 145 minutes; male Wistar rats) treatment significantly reduces infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rats (240-350 g)[3]
    Dosage: Bolus injection 10 mg/kg and infusion (9.6 mg/kg/h)
    Administration: Bolus injection; for 145 minutes
    Result: Significantly reduced infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion.
    Clinical Trial
    Molecular Weight

    500.46

    Formula

    C₂₄H₃₅Cl₂N₃O₄

    CAS No.

    95635-56-6

    SMILES

    O=C(NC1=C(C)C=CC=C1C)CN2CCN(CC(O)COC3=CC=CC=C3OC)CC2.[H]Cl.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 50 mg/mL (99.91 mM)

    H2O : ≥ 50 mg/mL (99.91 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9982 mL 9.9908 mL 19.9816 mL
    5 mM 0.3996 mL 1.9982 mL 3.9963 mL
    10 mM 0.1998 mL 0.9991 mL 1.9982 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.92%

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    Keywords:

    RanolazineCVT 303 RS 43285CVT303CVT-303RS43285RS 43285RS-43285Calcium ChannelSodium ChannelAutophagyCa2+ channelsCa channelsNa channelsNa+ channelsInhibitorinhibitorinhibit

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    Product Name:
    Ranolazine dihydrochloride
    Cat. No.:
    HY-17401
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