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  4. SDZ 51641

SDZ 51641 is an orally active fatty acid oxidation inhibitor. By reducing fatty acid oxidation, SDZ 51641 deprives the gluconeogenesis process of required energy and cofactors, thereby lowering blood glucose levels in diabetic models. SDZ 51641 can be used in diabetes research.

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SDZ 51641

SDZ 51641 Chemical Structure

CAS No. : 91456-99-4

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Description

SDZ 51641 is an orally active fatty acid oxidation inhibitor. By reducing fatty acid oxidation, SDZ 51641 deprives the gluconeogenesis process of required energy and cofactors, thereby lowering blood glucose levels in diabetic models. SDZ 51641 can be used in diabetes research[1].

In Vivo

SDZ 51641 (70-100 μmol/kg; p.o.; days 1-11) reduces fatty acid oxidation and blood glucose levels without causing peripheral toxicity in 18-hour fasted normal Sprague‑Dawley rats and streptozotocin (STZ) (HY-13753)-induced diabetic rats[1].
SDZ 51641 (700 µmol/kg; p.o.; once daily; for 28 days) reduces body weight and testicular weight, while increases liver weight, in normal Sprague Dawley rats compared with the control group[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague‑Dawley rats treated STZ[1]
Dosage: 70 µmol/kg
Administration: p.o.; daily; 11 days
Result: Inhibited hepatic fatty acid oxidation, decreased β‑hydroxybutyrate levels, reduced blood glucose production, and lowered serum glucose levels, while avoiding toxic effects on peripheral tissues such as the testes.
Molecular Weight

220.31

Formula

C14H20O2
CAS No.
SMILES

CC(C=C1)=CC=C1C2(C(C)(C)C)OCCO2
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Keywords:

SDZ 5164191456-99-4SDZ51641SDZ-51641Drug IntermediateDrug Iintermediatelong-chain acyl dehydrogenasefatty acid oxidationSTZ-induced diabetic ratsgluconeogenesisSprague Dawley ratstesticular toxicitycarnitine palmitoyl transferase 2intramitochondrial CoAacetyl-CoAnon-insulin-dependent diabetes mellitusInhibitorinhibitorinhibit

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