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PDM

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By Targets:	Akt (1) Apoptosis (1) Aryl Hydrocarbon Receptor (1) Autophagy (1) Biochemical Assay Reagents (3) DNA Stain (1) EGFR (1) Enterovirus (1) Environmental Pollutants (2) Fluorescent Dye (1) Influenza Virus (5) Ligands for Target Protein for PROTAC (2) mTOR (1) p38 MAPK (1) Phosphatase (1) Phosphodiesterase (PDE) (2) PROTAC Linkers (1) PROTACs (1) Reactive Oxygen Species (ROS) (2) SARS-CoV (1)
By Research Areas:	Cancer (4) Infection (5) Inflammation/Immunology (1) Neurological Disease (3)
Click Chemistry:	Labeling and Fluorescence Imaging (1)

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Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137383

Sulfo-SANPAH	Biochemical Assay Reagents Reactive Oxygen Species (ROS)	Others
Sulfo-SANPAH is a primary amine-nitrobenzene azide cross-linker. Sulfo-SANPAH improves the functionalization process of PDMS surfaces, is covalently bound to the PAAm gel surface. Sulfo-SANPAH is widely used to crosslink ECM proteins to various substrates, including acrylic-based hydrogels, such as polyacrylamide hydrogels. Sulfo-SANPAH facilitates covalent binding through its negatively charged sulfonate group on its N-hydroxysuccinimide ester ring and a photoactivated phenyl azide group that is highly reactive with nucleophiles and free radicals .

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis	Infection Neurological Disease
Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .

HY-D1725

Cy3-dCTP	Fluorescent Dye DNA Stain	Others
Cy3-dCTP is a directly fluorescently labeled deoxyribonucleotide, in which Cy3 is a cyanine fluorescent dye. Cy3-dCTP is used for direct enzymatic labeling of DNA and cDNA: with the aid of DNA polymerases, this modified nucleotide is incorporated into the extending DNA strand during processes such as reverse transcription, PCR, nick translation or random primer labeling .

HY-104035H

Dimethyl silicone oil, viscosity 10 cSt (25 °C) Poly(dimethylsiloxane) (PDMS), viscosity 10 cSt (25 °C); Dimethylsilcone fluid, viscosity 10 cSt (25 °C)	Environmental Pollutants Biochemical Assay Reagents	Others
Dimethyl silicone oil, viscosity 10 cSt (25 °C) (Poly(dimethylsiloxane) (PDMS), viscosity 10 cSt (25 °C); Dimethylsilcone fluid, viscosity 10 cSt (25 °C)) is a low-viscosity polydimethylsiloxane fluid with high thermal stability. Dimethyl silicone oil, viscosity 10 cSt (25 °C) can be used as a laboratory bath solution, calibration solution, defoamer, and also has applications in the biomedical field, such as as an intraocular solution.

HY-104035E

Dimethyl silicone oil, viscosity 100 cSt (25 °C) Poly(dimethylsiloxane) (PDMS), viscosity 100 cSt (25 °C); Dimethylsilcone fluid, viscosity 100 cSt (25 °C)	Environmental Pollutants Biochemical Assay Reagents	Others
Dimethyl silicone oil, viscosity 100 cSt (25 °C) (Poly(dimethylsiloxane) (PDMS), viscosity 100 cSt (25 °C); Dimethylsilcone fluid, viscosity 100 cSt (25 °C)) is a transparent, colorless, and inert polydimethylsiloxane liquid with stable properties. Dimethyl silicone oil, viscosity 100 cSt (25 °C) exhibits high dielectric strength and excellent lubrication, cushioning, and thermal conductivity. Dimethyl silicone oil, viscosity 100 cSt (25 °C) can be used in cosmetics, lubricants, and electronics.

HY-112629

PDM2 3 Publications Verification	Aryl Hydrocarbon Receptor	Inflammation/Immunology
PDM2 is a selective, high-affinity aryl hydrocarbon receptor (AhR) antagonist with an K_i of 1.2±0.4 nM.

HY-102043

PDM-631	Phosphodiesterase (PDE)	Neurological Disease
PDM-631 is a selective and orally active PDE2A inhibitor with blood-brain barrier penetration. PDM-631 exhibits potent inhibitory activity against human and rat recombinant PDE2A with IC₅₀ values of 1.5 nM and 4.2 nM, respectively. PDM-631 increases cGMP levels in the rat cerebral cortex. PDM-631 can be used for the study of schizophrenia and neurodegenerative disorders .

HY-176166

PD-M6	mTOR PROTACs Autophagy	Cancer
PD-M6 is a mTOR PROTAC degrader (DC₅₀: 4.8 μM). PD-M6 promotes ubiquitination and degradation of mTOR. PD-M6 downregulates MAPKAP1 and CASTOR1, and induces Autophagy. PD-M6 inhibits the proliferation of cervical cancer, breast cancer and liver cancer cell lines. PD-M6 can be used for the research of cervical cancer, breast cancer and liver cancer .

HY-112554

PDM11	Phosphatase	Others
PDM11 is a derivative of antioxidant resveratrol. PDM11 do not exhibit any significant protective effect against oxidation of linoleate micelles initiated by radiolysis-generated hydroxyl radicals. PDM11 is inactive in resveratrol activity assays .

HY-P10975

P9R	SARS-CoV Influenza Virus Enterovirus	Infection
P9R is an antiviral peptide. P9R has broad-spectrum antiviral activities against the coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), *A(H1N1)pdm09, A(H7N9) virus, and rhinovirus. P9R directly binds to viruses and inhibits virus-host endosomal acidification. P9R significantly protects mice from A(H1N1)pdm09* infection without generating drug-resistant virus. P9R can be used for pH-dependent respiratory viruses research .

HY-160111

PDM-042	Phosphodiesterase (PDE)	Neurological Disease
PDM-042 is a potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. PDM-042 shows potent inhibitory activities for human and rat PDE10A with IC₅₀ values of less than 1 nM and more than 1000-fold selectivity against other phosphodiesterases. PDM-042 can be used for the research of schizophrenia .

HY-100858

PP7	Influenza Virus	Infection
PP7 is a potent PB1-PB2 interaction inhibitor with an IC₅₀ of 8.6 μM, and their inhibition against viral polymerase activity (IC₅₀=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC₅₀=1.4 μM), A(H7N9) and A(H9N2) subtypes .

HY-129773

*Phthalimide-PEG4-PDM-OTBS*	PROTAC Linkers	Cancer
Phthalimide-PEG4-PDM-OTBS is a PROTAC linker, which refers to the PEGs composition. Phthalimide-PEG4-PDM-OTBS can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins .

HY-155476

Influenza virus-IN-8	Influenza Virus	Infection
Influenza virus-IN-8 (compound A4) is an inhibitor of influenza virus (Influenza Virus) that induces viral nucleoprotein (NP) aggregation and prevents its nuclear accumulation. Influenza virus-IN-8 has broad-spectrum anti-influenza activity and can inhibit the replication and transcription of influenza A virus. Influenza virus-IN-8 also inhibits Oseltamivir (HY-13317)-resistant H1N1/pdm09 strains .

HY-W150930

mTOR ligand 1	Ligands for Target Protein for PROTAC	Cancer
mTOR ligand 1 (compound T2) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). mTOR ligand 1 can serve as an active control for MHY1485 (HY-B0795, the target protein ligand of PD-M6 (HY-176166) .

HY-176167

mTOR ligand 1-C6-amino	Ligands for Target Protein for PROTAC	Cancer
mTOR ligand 1-C6-amino is a conjugate of a target protein ligand (HY-B0795) and a linker (HY-W008296). mTOR ligand 1-C6-amino can be used to synthesize PROTAC PD-M6 (HY-176166) .

HY-180525

PB2-IN-2	Influenza Virus	Infection
PB2-IN-2 is an orally active PB2 inhibitor with RNA-dependent RNA Polymerase (RNP) IC₅₀ = 0.2 nM, LRA (Ligand Receptor Assay) EC₅₀ = 0.8 nM, Cytopathic Effect (CPE) EC₅₀ = 0.1 nM. PB2-IN-2 exhibits broad-spectrum, nanomolar antiviral potency against a panel of influenza A strains (including H1N1pdm09, Lyon/1337/2007/H1N1, Tex12-Like/H3N2, PR/8/34/H1N1, WSN/1933/H1N1, rPR8(H1N1)/H7N9 with EC₅₀ = 1.5, 3.6, 3.7, 13.8, 2.9 and 9.8 nM and all the CC₅₀ values > 2 μM. PB2-IN-2 possesses an excellent pharmacokinetic profile and metabolic stability. PB2-IN-2 can be used for anti-influenza research .

Cy3-dCTP	Fluorescent Dye
Cy3-dCTP is a directly fluorescently labeled deoxyribonucleotide, in which Cy3 is a cyanine fluorescent dye. Cy3-dCTP is used for direct enzymatic labeling of DNA and cDNA: with the aid of DNA polymerases, this modified nucleotide is incorporated into the extending DNA strand during processes such as reverse transcription, PCR, nick translation or random primer labeling .

Cat. No.	Product Name	Type

HY-104035H

Dimethyl silicone oil, viscosity 10 cSt (25 °C) Poly(dimethylsiloxane) (PDMS), viscosity 10 cSt (25 °C); Dimethylsilcone fluid, viscosity 10 cSt (25 °C)	Biochemical Assay Reagents
Dimethyl silicone oil, viscosity 10 cSt (25 °C) (Poly(dimethylsiloxane) (PDMS), viscosity 10 cSt (25 °C); Dimethylsilcone fluid, viscosity 10 cSt (25 °C)) is a low-viscosity polydimethylsiloxane fluid with high thermal stability. Dimethyl silicone oil, viscosity 10 cSt (25 °C) can be used as a laboratory bath solution, calibration solution, defoamer, and also has applications in the biomedical field, such as as an intraocular solution.

Dimethyl silicone oil, viscosity 10 cSt (25 °C)

Poly(dimethylsiloxane) (PDMS), viscosity 10 cSt (25 °C); Dimethylsilcone fluid, viscosity 10 cSt (25 °C)

Biochemical Assay Reagents

Dimethyl silicone oil, viscosity 10 cSt (25 °C) (Poly(dimethylsiloxane) (PDMS), viscosity 10 cSt (25 °C); Dimethylsilcone fluid, viscosity 10 cSt (25 °C)) is a low-viscosity polydimethylsiloxane fluid with high thermal stability. Dimethyl silicone oil, viscosity 10 cSt (25 °C) can be used as a laboratory bath solution, calibration solution, defoamer, and also has applications in the biomedical field, such as as an intraocular solution.

HY-104035E

Dimethyl silicone oil, viscosity 100 cSt (25 °C) Poly(dimethylsiloxane) (PDMS), viscosity 100 cSt (25 °C); Dimethylsilcone fluid, viscosity 100 cSt (25 °C)	Biochemical Assay Reagents
Dimethyl silicone oil, viscosity 100 cSt (25 °C) (Poly(dimethylsiloxane) (PDMS), viscosity 100 cSt (25 °C); Dimethylsilcone fluid, viscosity 100 cSt (25 °C)) is a transparent, colorless, and inert polydimethylsiloxane liquid with stable properties. Dimethyl silicone oil, viscosity 100 cSt (25 °C) exhibits high dielectric strength and excellent lubrication, cushioning, and thermal conductivity. Dimethyl silicone oil, viscosity 100 cSt (25 °C) can be used in cosmetics, lubricants, and electronics.

Dimethyl silicone oil, viscosity 100 cSt (25 °C)

Poly(dimethylsiloxane) (PDMS), viscosity 100 cSt (25 °C); Dimethylsilcone fluid, viscosity 100 cSt (25 °C)

Biochemical Assay Reagents

Dimethyl silicone oil, viscosity 100 cSt (25 °C) (Poly(dimethylsiloxane) (PDMS), viscosity 100 cSt (25 °C); Dimethylsilcone fluid, viscosity 100 cSt (25 °C)) is a transparent, colorless, and inert polydimethylsiloxane liquid with stable properties. Dimethyl silicone oil, viscosity 100 cSt (25 °C) exhibits high dielectric strength and excellent lubrication, cushioning, and thermal conductivity. Dimethyl silicone oil, viscosity 100 cSt (25 °C) can be used in cosmetics, lubricants, and electronics.

Cat. No.	Product Name	Target	Research Area

HY-P10975

P9R	SARS-CoV Influenza Virus Enterovirus	Infection
P9R is an antiviral peptide. P9R has broad-spectrum antiviral activities against the coronaviruses (SARS-CoV-2, MERS-CoV and SARS-CoV), *A(H1N1)pdm09, A(H7N9) virus, and rhinovirus. P9R directly binds to viruses and inhibits virus-host endosomal acidification. P9R significantly protects mice from A(H1N1)pdm09* infection without generating drug-resistant virus. P9R can be used for pH-dependent respiratory viruses research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7922

Urolithin M5 1 Publications Verification Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Source Classification	Influenza Virus p38 MAPK EGFR Akt Reactive Oxygen Species (ROS) Apoptosis
Urolithin M5 (Decarboxyellagic acid) is an orally active influenza virus neuraminidase inhibitor and neuroprotective agent, with IC₅₀ values of 174.8 μM (HK68), 191.5 μM (pdm09), 243.2 μM (WSN) and 257.1 μM (PR8) against four influenza virus neuraminidases, respectively. Urolithin M5 inhibits viral neuraminidase activity, thereby blocking influenza virus replication (including oseltamivir (HY-13317)-resistant strains), protecting infected mammals from death and improving pulmonary edema. Urolithin M5 forms a hydrogen-bond stabilized complex with IGF1R, and binds to MAPK14, AKT1, NFKB1 and EGFR. Urolithin M5 reduces reactive oxygen species production, inhibits neuronal apoptosis, restores mitochondrial transmembrane potential, and promotes neurite outgrowth of damaged neuronal cells. Urolithin M5 can be used in research related to influenza virus infection and Alzheimer's disease .

Cat. No.	Product Name		Classification

HY-D1725

Cy3-dCTP		Labeling and Fluorescence Imaging
Cy3-dCTP is a directly fluorescently labeled deoxyribonucleotide, in which Cy3 is a cyanine fluorescent dye. Cy3-dCTP is used for direct enzymatic labeling of DNA and cDNA: with the aid of DNA polymerases, this modified nucleotide is incorporated into the extending DNA strand during processes such as reverse transcription, PCR, nick translation or random primer labeling .

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PDM

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Click Chemistry

Natural
Products