PDM-042
PDM-042 is a potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. PDM-042 shows potent inhibitory activities for human and rat PDE10A with IC50 values of less than 1 nM and more than 1000-fold selectivity against other phosphodiesterases. PDM-042 can be used for the research of schizophrenia.
For research use only. We do not sell to patients.
- CAS No.: 1404488-48-7
- Formula: C21H26N8O
- Molecular Weight:406.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
IC50 & Target
IC50: <1 nM (for human and rat PDE10A)[1]
Chemical Information
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CAS No. 1404488-48-7
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Molecular Weight 406.48
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Formula C21H26N8O
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SMILES
CC1=NC=C(C)N2C1=NC(/C=C/C3=NC(N4CCCC4)=CC(N5CCOCC5)=N3)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
[1]. Arakawa K, et al. Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 10A inhibitor, PDM-042 [(E)-4-(2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)vinyl)-6-(pyrrolidin-1-yl)pyrimidin-4-yl)morpholine] in rats: potential for the treatment of schizophrenia. Pharmacol Res Perspect. 2016 Jun 10;4(4):e00241. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)