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Isoforms Recommended: ULK2
Results for "

Ulk2

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

2

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16966
    SBI-0206965
    Maximum Cited Publications
    40 Publications Verification

    		 ULK AMPK Autophagy Apoptosis Cancer
    SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50s of 108 nM for ULK1 kinase and 711 nM for the highly related kinase ULK2. SBI-0206965 is also an AMPK inhibitor that can paradoxically increase Thr172 phosphorylation [2] .
    SBI-0206965
  • HY-13018
    MRT67307
    25+ Cited Publications

    		 IKK ULK Autophagy Inflammation/Immunology Cancer
    MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively . MRT67307 also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells [2].
    MRT67307
  • HY-147141
    HS-276
    2 Publications Verification

    		 IRAK TNF Receptor Casein Kinase Interleukin Related Inflammation/Immunology
    HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 reduces the expression of TNF, IL-6, and IL-1β. HS-276 can be used for rheumatoid arthritis (RA) research .
    HS-276
  • HY-114490
    ULK-101
    5+ Cited Publications

    		 ULK Cancer
    ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress .
    ULK-101
  • HY-100006
    MRT68921
    25+ Cited Publications

    		 ULK Reactive Oxygen Species (ROS) Apoptosis GSK-3 Bcl-2 Family Cancer
    MRT68921 is a potent NUAK1/ULK1 dual inhibitor. MRT68921 inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 can be used for the research of cancer, such as breast cancer [2].
    MRT68921
  • HY-100006A
    MRT68921 dihydrochloride
    25+ Cited Publications

    		 ULK Reactive Oxygen Species (ROS) Apoptosis GSK-3 Bcl-2 Family Cancer
    MRT68921 dihydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 dihydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer [2].
    MRT68921 dihydrochloride
  • HY-137742
    SBP-7455

    		ULK Autophagy Cancer
    SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research .
    SBP-7455
  • HY-137506
    XST-14
    2 Publications Verification

    		 ULK p38 MAPK TGF-β Receptor Anaplastic lymphoma kinase (ALK) CaMK Apoptosis Cancer
    XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects .
    XST-14
  • HY-13018A
    MRT67307 hydrochloride

    		IKK ULK Autophagy Inflammation/Immunology Cancer
    MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively . MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells [2].
    MRT67307 hydrochloride
  • HY-RS15456
    Ulk2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ulk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ulk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ulk2 Rat Pre-designed siRNA Set A
    Ulk2 Rat Pre-designed siRNA Set A
  • HY-RS15454
    ULK2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) ULK Others

    ULK2 Human Pre-designed siRNA Set A contains three designed siRNAs for ULK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ULK2 Human Pre-designed siRNA Set A
    ULK2 Human Pre-designed siRNA Set A
  • HY-RS15455
    Ulk2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) ULK Others

    Ulk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ulk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ulk2 Mouse Pre-designed siRNA Set A
    Ulk2 Mouse Pre-designed siRNA Set A
  • HY-13018B
    MRT67307 dihydrochloride

    		IKK ULK Autophagy Inflammation/Immunology Cancer
    MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively . MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells [2].
    MRT67307 dihydrochloride
  • HY-100006B
    MRT68921 hydrochloride

    		ULK Reactive Oxygen Species (ROS) Apoptosis GSK-3 Bcl-2 Family Cancer
    MRT68921 hydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 hydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 hydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 hydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 hydrochloride can be used for the research of cancer, such as breast cancer [2].
    MRT68921 hydrochloride
  • HY-181815
    SBP-5147

    		ULK Beclin1 Autophagy MHC Caspase Apoptosis Cancer
    SBP-5147 is an orally active ULK1/ULK2 inhibitor, with an IC50 of 2 nM against ULK1 and an IC50 of 53 nM against ULK2. SBP-5147 inhibits the phosphorylation of Beclin-1 and Vps34, reduces autophagy flux, downregulates the expression of ATG13 and ATG101, upregulates the expression of MHC-I, induces caspase-dependent apoptosis, and decreases the viability of non-small cell lung cancer cells. SBP-5147 is applicable to research related to non-small cell lung cancer [1] [2].
    SBP-5147
  • HY-100006AR
    MRT68921 dihydrochloride (Standard)

    		ULK Reference Standards Reactive Oxygen Species (ROS) Apoptosis GSK-3 Bcl-2 Family Cancer
    MRT68921 (dihydrochloride) (Standard) is the analytical standard of MRT68921 (dihydrochloride) (HY-100006A). This product is intended for research and analytical applications. MRT68921 dihydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 dihydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer [2].
    MRT68921 dihydrochloride (Standard)
  • HY-147141A
    HS-276 hydrochloride

    		IRAK TNF Receptor Casein Kinase Interleukin Related Inflammation/Immunology
    HS-276 hydrochloride is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 hydrochloride shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 hydrochloride reduces the expression of TNF, IL-6, and IL-1β. HS-276 hydrochloride can be used for rheumatoid arthritis (RA) research .
    HS-276 hydrochloride
  • HY-147141B
    HS-276 formic

    		IRAK TNF Receptor Casein Kinase Interleukin Related Inflammation/Immunology
    HS-276 formic is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 formic shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 formic reduces the expression of TNF, IL-6, and IL-1β. HS-276 formic can be used for rheumatoid arthritis (RA) research .
    HS-276 formic
  • HY-181668
    ULK1-IN-4

    		ULK Cancer
    ULK1-IN-4 (compound 12i) is a ULK1 inhibitor with an IC50 of 4.7 μM against human ULK1, and it exhibits selectivity for Aurora A/Aurora B kinases. ULK1-IN-4 forms a covalent bond with the thiol group of the Cys182 residue of ULK1, thereby inhibiting the kinase activity of ULK1. ULK1-IN-4 inhibits the growth of colorectal cancer cells and exerts tumor-suppressive activity in a mouse model of colorectal cancer .
    ULK1-IN-4

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