Copy Link Print Information

MRT67307 dihydrochloride

30 Cited Publications
Customer Review

Based on 30 publication(s) in Google Scholar

MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells.

For research use only. We do not sell to patients.

  • CAS No.: 1781882-89-0
  • Formula: C26H38Cl2N6O2
  • Molecular Weight:537.52
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • MRT67307 dihydrochloride Chemical Structure
    MRT67307 dihydrochloride Chemical Structure
  • Experimental Validation Results for MRT67307 dihydrochloride
  • Experimental Validation Results for MRT67307 dihydrochloride
  • Experimental Validation Results for MRT67307 dihydrochloride
  • Experimental Validation Results for MRT67307 dihydrochloride
  • Experimental Validation Results for MRT67307 dihydrochloride
CAS No.: 1781882-89-0
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of MRT67307 dihydrochloride:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Protocols
  • Purity & Documentation
  • References
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) MRT67307 dihydrochloride

More
Customer Validation & Images
WBCell Imaging/Staining
  • WB
  • Cell Imaging/Staining
  • WB
  • WB
  • WB

All IKK Isoforms

More

All ULK Isoforms

More

Keywords

MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • MRT67307 dihydrochloride Chemical Structure
    MRT67307 dihydrochloride Chemical Structure
    1/16
  • 1/16

    MRT67307 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Dec;27(12):2143-2151. [Abstract]

    Customer Validation
     Total STAT1 levels in A375 persister cells cotreated for 14 days with 1 μM TBK1 inhibitor MRT67307 (TBK1i) or 1 μM JAKi.

  • 1/16

    MRT67307 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 28;16(1):1109. [Abstract]

    Customer Validation
     HepG2/GFP-Gal3 cells were treated with either MRT67307 (2 µM) or GSK8612 (10 µM) in combination with LLOMe (750 µM). After the 2-h treatment, LLOMe was washed out with normal cell culture media, and the cells were further incubated with either MRT67307 or GSK8612 for 24 h. The number of GFP-Gal3 puncta was quantified.

  • 1/16

    MRT67307 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 28;16(1):1109. [Abstract]

    Customer Validation
     HepG2 cells were transfected with both HA-ubiquitin and TMEM192-FLAG and pretreated with either MRT67307 (MRT, 2 µM) or GSK8612 (10 µM). LLOMe was cotreated for an additional 2 h. Subsequently, the cells were immunoprecipitated with agarose bead-conjugated anti-FLAG antibody and further analyzed by western blotting using the indicated antibodies. The results demonstrate that treatment with the TBK1 inhibitor MRT67307 (MRT) attenuated the LLOMe-induced increase in TMEM192 ubiquitination levels.

  • 1/16

    MRT67307 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Med. 2018 Aug;24(8):1143-1150. [Abstract]

    Customer Validation
     Immunoblot of pSTAT1, STAT1 and β-actin levels in H69AR cells±200 ng/mL IFNg 10 min pulse followed by 24 h chase in media with DMSO, Ruxolitinib (100 nM) or MRT67307 (1 µM).

  • 1/16

    MRT67307 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2015 Jan 21:6:6074. [Abstract]

    Customer Validation
     MRT67307 efficiently inhibited the AKT degradation. IB analysis using WT CD4+ T cells, pretreated for 1 h with a TBK1 inhibitor, MRT67307, of solvent control DMSO and subsequently stimulated for the indicated times with anti-CD3 plus anti-CD28 in the presence of a protein synthesis inhibitor, Cycloheximide.

  • MRT67307 dihydrochloride