MRT67307 dihydrochloride
Based on 28 publication(s) in Google Scholar
MRT67307 dihydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 dihydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 dihydrochloride also blocks autophagy in cells.
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- CAS No.: 1781882-89-0
- Formule: C26H38Cl2N6O2
- Masse moléculaire:537.52
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Publications Citing Use of MedChemExpress (MCE) MRT67307 dihydrochloride
More- Nature. 2023 Mar;615(7950):158-167. [Abstract]
- Nat Med. 2018 Aug;24(8):1143-1150. [Abstract]
- Cell Res. 2019 Mar;29(3):193-205. [Abstract]
- Nat Cell Biol. 2025 Dec;27(12):2143-2151. [Abstract]
- Autophagy. 2026 Feb;22(2):316-329. [Abstract]
- Nat Commun. 2025 Jan 28;16(1):1109. [Abstract]
- Nat Commun. 2023 Sep 18;14(1):5666. [Abstract]
- Nat Commun. 2015 Jan 21:6:6074. [Abstract]
- Mol Cell. 2020 Dec 3;80(5):810-827.e7. [Abstract]
- Theranostics. 2018 Sep 9;8(17):4633-4648. [Abstract]
- Cell Chem Biol. 2022 Jul 21;29(7):1113-1125.e6. [Abstract]
- Int J Mol Med. 2018 Jul;42(1):248-258. [Abstract]
- Blood Adv. 2018 Dec 11;2(23):3428-3442. [Abstract]
- Mol Ther Methods Clin Dev. 2025 Jul 28;33(3):101542. [Abstract]
- Sci Rep. 2025 Dec 3. [Abstract]
- Clin Immunol. 2026 Feb:283:110654. [Abstract]
- Biochem J. 2019 Mar 12;476(5):875-887. [Abstract]
- Mol Immunol. 2021 Mar:131:180-190. [Abstract]
- J Immunol Res. 2023 Mar 31:2023:5990156. [Abstract]
- bioRxiv. 2026 Mar 12.
- bioRxiv. 2025 Aug 21:2025.08.15.670603. [Abstract]
- bioRxiv. 2025 January 22.
- Patent. US20220305048A1.
- Patent. US20210025893A1.
- Patent. US20200246435A1.
- Harvard Medical School. 2018 June 13.
- Patent. US9814741B2.
- Patent. US20150202223A1.
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Activité biologique
Chemical Information
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CAS No. 1781882-89-0
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Masse moléculaire 537.52
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Formule C26H38Cl2N6O2
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SMILES
O=C(C1CCC1)NCCCNC2=NC(NC3=CC=CC(CN4CCOCC4)=C3)=NC=C2C5CC5.[H]Cl.[H]Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (28)
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Journal Impact Factor
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Most Recent
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Nature
2023 Mar;615(7950):158-167. PMID: 36634707 -
Nat Med
2018 Aug;24(8):1143-1150. PMID: 30038220
MRT67307 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Med. 2018 Aug;24(8):1143-1150. [Abstract]
Immunoblot of pSTAT1, STAT1 and β-actin levels in H69AR cells±200 ng/mL IFNg 10 min pulse followed by 24 h chase in media with DMSO, Ruxolitinib (100 nM) or MRT67307 (1 µM).
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Cell Res
Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity. [Abstract]2019 Mar;29(3):193-205. PMID: 30651583 -
Nat Cell Biol
DNA fragmentation factor B suppresses interferon to enable cancer persister cell regrowth. [Abstract]2025 Dec;27(12):2143-2151. PMID: 41249572
MRT67307 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2025 Dec;27(12):2143-2151. [Abstract]
Total STAT1 levels in A375 persister cells cotreated for 14 days with 1 μM TBK1 inhibitor MRT67307 (TBK1i) or 1 μM JAKi.
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Autophagy
Regulation of pexophagy by a novel TBK1-MARCHF7-PXMP4-NBR1 axis in PEX1-depleted HeLa cells. [Abstract]2026 Feb;22(2):316-329. PMID: 41267209 -
Nat Commun
Activation of lysophagy by a TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis in response to lysosomal damage. [Abstract]2025 Jan 28;16(1):1109. PMID: 39875384
MRT67307 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 28;16(1):1109. [Abstract]
HepG2/GFP-Gal3 cells were treated with either MRT67307 (2 µM) or GSK8612 (10 µM) in combination with LLOMe (750 µM). After the 2-h treatment, LLOMe was washed out with normal cell culture media, and the cells were further incubated with either MRT67307 or GSK8612 for 24 h. The number of GFP-Gal3 puncta was quantified.
MRT67307 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 28;16(1):1109. [Abstract]
HepG2 cells were transfected with both HA-ubiquitin and TMEM192-FLAG and pretreated with either MRT67307 (MRT, 2 µM) or GSK8612 (10 µM). LLOMe was cotreated for an additional 2 h. Subsequently, the cells were immunoprecipitated with agarose bead-conjugated anti-FLAG antibody and further analyzed by western blotting using the indicated antibodies. The results demonstrate that treatment with the TBK1 inhibitor MRT67307 (MRT) attenuated the LLOMe-induced increase in TMEM192 ubiquitination levels.
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Nat Commun
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection. [Abstract]2023 Sep 18;14(1):5666. PMID: 37723181 -
Nat Commun
Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation. [Abstract]2015 Jan 21:6:6074. PMID: 25606824
MRT67307 dihydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2015 Jan 21:6:6074. [Abstract]
MRT67307 efficiently inhibited the AKT degradation. IB analysis using WT CD4+ T cells, pretreated for 1 h with a TBK1 inhibitor, MRT67307, of solvent control DMSO and subsequently stimulated for the indicated times with anti-CD3 plus anti-CD28 in the presence of a protein synthesis inhibitor, Cycloheximide.
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Mol Cell
TBK1-Mediated DRP1 Targeting Confers Nucleic Acid Sensing to Reprogram Mitochondrial Dynamics and Physiology. [Abstract]2020 Dec 3;80(5):810-827.e7. PMID: 33171123 -
Theranostics
Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKKɛ/TBK1/NF-κB signaling. [Abstract]2018 Sep 9;8(17):4633-4648. PMID: 30279728 -
Cell Chem Biol
Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses. [Abstract]2022 Jul 21;29(7):1113-1125.e6. PMID: 35728599 -
Int J Mol Med
Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media. [Abstract]2018 Jul;42(1):248-258. PMID: 29568908 -
Blood Adv
The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy. [Abstract]2018 Dec 11;2(23):3428-3442. PMID: 30504235 -
Mol Ther Methods Clin Dev
Enhanced B cell electroporation efficiency via inhibition of DNA-induced apoptosis and pyroptosis with pan-caspase inhibitor. [Abstract]2025 Jul 28;33(3):101542. PMID: 40821855 -
Sci Rep
Pseudomonas aeruginosa-derived DnaJ functions as a novel immunomodulator inducing IFNβ via CME-SGK1-IRF3 axis in macrophages. [Abstract]2025 Dec 3. PMID: 41339751 -
Clin Immunol
Development and validation of a flow cytometry-based ISG15 induction assay to monitor the type I interferon response. [Abstract]2026 Feb:283:110654. PMID: 41344526 -
Biochem J
Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2). [Abstract]2019 Mar 12;476(5):875-887. PMID: 30782972 -
Mol Immunol
DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells. [Abstract]2021 Mar:131:180-190. PMID: 33423764 -
J Immunol Res
c-Myb Dominates TBK1-Mediated Endotoxin Tolerance in Kupffer Cells by Negatively Regulating DTX4. [Abstract]2023 Mar 31:2023:5990156. PMID: 37032653 -
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bioRxiv
2025 Aug 21:2025.08.15.670603. PMID: 40894800 -
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Pureté et documentation
Références
[1]. Clark K, et al. Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104. [Content Brief]
[2]. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83. [Content Brief]
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