1. NF-κB
    Autophagy
  2. IKK
    ULK
    Autophagy
  3. MRT67307 hydrochloride

MRT67307 hydrochloride 

Cat. No.: HY-13018A
Handling Instructions

MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively. MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells.

For research use only. We do not sell to patients.

MRT67307 hydrochloride Chemical Structure

MRT67307 hydrochloride Chemical Structure

CAS No. : 2095432-39-4

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of MRT67307 hydrochloride:

Other Forms of MRT67307 hydrochloride:

Top Publications Citing Use of Products

    MRT67307 hydrochloride purchased from MCE. Usage Cited in: Nat Commun. 2015 Jan 21;6:6074.

    MRT67307 efficiently inhibits the AKT degradation. IB analysis using WT CD4+ T cells, pretreated for 1 h with a TBK1 inhibitor, MRT67307, of solvent control DMSO and subsequently stimulated for the indicated times with anti-CD3 plus anti-CD28 in the presence of a protein synthesis inhibitor, Cycloheximide.

    MRT67307 hydrochloride purchased from MCE. Usage Cited in: Nat Med. 2018 Aug;24(8):1143-1150.

    Immunoblot of pSTAT1, STAT1 and β-actin levels in H69AR cells±200 ng/mL IFNg 10 min pulse followed by 24 h chase in media with DMSO, Ruxolitinib (100 nM) or MRT67307 (1 µM).

    View All IKK Isoform Specific Products:

    View All ULK Isoform Specific Products:

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    MRT67307 hydrochloride is a dual inhibitor of the IKKε and TBK-1 with IC50s of 160 and 19 nM, respectively[1]. MRT67307 hydrochloride also inhibits ULK1 and ULK2 with IC50s of 45 and 38 nM, respectively. MRT67307 hydrochloride also blocks autophagy in cells[2].

    IC50 & Target[1][2]

    TBK1

    19 nM (IC50, at 0.1 mM ATP)

    IKKε

    160 nM (IC50, at 0.1 mM ATP)

    ULK2

    38 nM (IC50)

    ULK1

    45 nM (IC50)

    Autophagy

     

    In Vitro

    MRT67307 inhibits IKKϵ and TBK1 with IC50 values of 160 and 19 nM when assayed at 0.1 mM ATP in vitro, but did not inhibit IKKα or IKKβ even at 10 μM[1].
    MRT67307 (2 μM) prevents the phosphorylation of IRF3 in bone-marrow-derived macrophages (BMDMs). MRT67307 (2 μM) dose not suppresse the activation of JNK or p38 MAPK by poly(I:C)[1].
    MRT67307 (1 nM-10 μM) prevents the production of IFNβ in macrophages[1].
    MRT67307 (10 μM) is sufficient to reduce phospho-ATG13 to control levels[2].
    MRT67307 (10 μM) blocks autophagy in mouse embryonic fibroblasts (MEFs)[2].
    MRT67307 (5 µM; 4 h) abrogates TBK1/IKKε-induced CYLD phosphorylation in 293T cells[3].

    Western Blot Analysis[3]

    Cell Line: 293T cells
    Concentration: 5 µM
    Incubation Time: 4 hours
    Result: Abrogated TBK1/IKKε-induced CYLD phosphorylation.
    Molecular Weight

    501.06

    Formula

    C₂₆H₃₇ClN₆O₂

    CAS No.

    2095432-39-4

    SMILES

    O=C(C1CCC1)NCCCNC2=NC(NC3=CC=CC(CN4CCOCC4)=C3)=NC=C2C5CC5.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    MRT67307MRT 67307MRT-67307IKKULKAutophagyIκB kinaseI kappa B kinase Unc-51 like kinaseIKKεTBK-1ULK1ULK2autophagysignaltransductioncancerInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product name:
    MRT67307 hydrochloride
    Cat. No.:
    HY-13018A
    Quantity:
    MCE Japan Authorized Agent: