2. Autophagy
  3. ULK
    Autophagy
  4. SBP-7455

SBP-7455 

Cat. No.: HY-137742 Purity: 98.29%
COA Handling Instructions

SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research.

For research use only. We do not sell to patients.

SBP-7455 Chemical Structure

SBP-7455 Chemical Structure

CAS No. : 1884222-74-5

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 182 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 182 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 165 In-stock
Estimated Time of Arrival: December 31
10 mg USD 275 In-stock
Estimated Time of Arrival: December 31
25 mg USD 495 In-stock
Estimated Time of Arrival: December 31
50 mg USD 715 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1045 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research[1].

IC50 & Target

ULK1

13 nM (IC50)

ULK2

476 nM (IC50)

In Vitro

SBP-7455 (compound 26; 72 h) treatment inhibits cell growth with an IC50 of 0.3 μM for MDA-MB-468 cells. SBP-7455 inhibits starvation-induced autophagic flux in TNBC cells that are dependent on autophagy for survival[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

A single dose of SBP-7455 (compound 26) (30 mg/kg) is orally administered to mice. The Tmax for SBP-7455 is approximately 1 h, the Cmax is 990 nM and the T1/2 is 1.7 h. The plasma concentration of SBP-7455 remains above the ULK1 IC50 for almost 4 h after oral dosing[1].
The mice are dosed with SBP-7455 (compound 26) (10 mg/kg) by oral gavage, and liver samples were collected after 2 h. The results reveals robust inhibition of pATG13 (Ser318), as well as downregulation of total ATG13 and ULK1 levels by SBP-7455[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

354.33

Appearance

Solid

Formula

C16H17F3N4O2
CAS No.
SMILES

FC(C1=CN=C(NC2=CC=C(OC)C(OC)=C2)N=C1NC3CC3)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (352.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8222 mL 14.1111 mL 28.2223 mL
5 mM 0.5644 mL 2.8222 mL 5.6445 mL
10 mM 0.2822 mL 1.4111 mL 2.8222 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.87 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.87 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

SBP-74551884222-74-5SBP7455SBP 7455ULKAutophagyUnc-51 like kinaseULK1ULK2autophagyTNBCpATG13Ser318oralInhibitorinhibitorinhibit

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