1884222-74-5
1884222-74-5
Chemical Structure
SBP-7455
- CAS No.: 1884222-74-5
- Formula:C16H17F3N4O2
- Molecular Weight:354.33
IUPAC Name: N4-cyclopropyl-N2-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
InChIKey: BQROJYIEHOOQBY-UHFFFAOYSA-N
SMILES: FC(C1=CN=C(NC2=CC=C(OC)C(OC)=C2)N=C1NC3CC3)(F)F
Biological Activity: SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research[1].
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SBP-7455 | 98.01% | SBP-7455 is a potent, high affinity and orally active dual ULK1/ULK2 autophagy inhibitor with IC50s of 13 nM and 476 nM in the ADP-Glo assays, respectively. SBP-7455 potently inhibits ULK1/2 enzymatic activity and can be used for triple-negative breast cancer (TNBC) research. | ||||||||||||||||||||
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References
Keywords
