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Results for "

apelin+receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apelin Receptor (APJ) (25) Arrestin (7) CXCR (1) Drug Isomer (1) Isotope-Labeled Compounds (1) Reference Standards (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (19) Inflammation/Immunology (2) Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109111

Azelaprag AMG 986	Apelin Receptor (APJ)	Others
Azelaprag (Example 263.0) is a candidate active molecule for an *Apelin receptor* agonist with an EC₅₀ of 0.32 nM for the apelin receptor .

HY-P1033

*[Pyr1]-Apelin-13* 4 Publications Verification [pGlu1]-Apelin-13	Apelin Receptor (APJ)	Cardiovascular Disease
[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.

HY-122197

ML339 4 Publications Verification	CXCR Apelin Receptor (APJ) Arrestin	Cancer
ML339 is a selective CXCR6 antagonist with an IC₅₀ of 140 nM. ML339 antagonizes β-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC₅₀ of 0.3 μM and 1.4 μM, respectively. ML339 shows weaker activity against the recruitment of β-arrestin in mouse CXCR6 receptors, with an IC₅₀ of 18 μM. ML339 has no inhibitory effect on CXCR5，CXCR4，CXCR6 and apelin receptor (APJ), with IC₅₀ >79 μM. ML339 has the potential to promote the development of prostate cancer research .

HY-108003

MM 07	Apelin Receptor (APJ)	Cardiovascular Disease
MM 07 is a biased *apelin receptor* agonist, with a K_D of 300 nM in CHO-K1 cells and a K_D of 172 nM in human heart.

HY-103080

CMF019	Apelin Receptor (APJ)	Cardiovascular Disease
CMF019 is an orally active, potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pKi values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents . Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin. CMF019 is promising for research of chronic diseases, such as, pulmonary arterial hypertension .

HY-125976

ML233	Apelin Receptor (APJ)	Cardiovascular Disease
ML233 is a non-peptide based potent apelin receptor (APJ) agonist (EC₅₀=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM) .

HY-P2106

Elabela(19-32) Maximum Cited Publications 6 Publications Verification	Arrestin Apelin Receptor (APJ)	Cardiovascular Disease
Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the G_αi1 and β-arrestin-2 signaling pathways with EC₅₀s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart .

HY-P2197

ELA-11(human)	Apelin Receptor (APJ) Arrestin	Inflammation/Immunology
ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pK_i of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment .

HY-P2106A

Elabela(19-32) TFA Maximum Cited Publications 6 Publications Verification	Apelin Receptor (APJ) Arrestin	Cardiovascular Disease
Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the G_αi1 and β-arrestin-2 signaling pathways with EC₅₀s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart .

HY-P2196A

ELA-32(human) TFA 1 Publications Verification	Apelin Receptor (APJ)	Cancer
ELA-32(human) TFA is a potent, high affinity apelin receptor agonist (IC₅₀=0.27 nM; K_d=0.51 nM). ELA-32(human) TFA exhibits no binding GPR15 and GPR25. ELA-32(human) TFA activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein translation. ELA-32(human) TFA also potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage. ELA-32(human) TFA stimulates angiogenesis in HUVEC cells.

HY-P3162A

*(Ala13)-Apelin-13 TFA*	Apelin Receptor (APJ)	Cardiovascular Disease
(Ala13)-Apelin-13 TFA is a potent apelin receptors (APJ) antagonist. (Ala13)-Apelin-13 TFA inhibits gastric motility through vagal cholinergic pathway .

HY-P2249

ELA-21 (human)	Arrestin Apelin Receptor (APJ)	Cardiovascular Disease
ELA-21 (human) is an *apelin receptor* agonist with a pK_i of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways .

HY-P2196

ELA-32(human)	Apelin Receptor (APJ)	Cardiovascular Disease
ELA-32 (human) is a potent critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor .

HY-147751

*APJ receptor* agonist 6**	Arrestin Apelin Receptor (APJ)	Cardiovascular Disease
APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with K_i of 1.3 μM. APJ receptor agonist 6 has EC₅₀ values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively .

HY-167712

(2R,3S)-Azelaprag (2R,3S)-AMG 986	Drug Isomer Apelin Receptor (APJ)	Cardiovascular Disease Metabolic Disease
(2R,3S)-Azelaprag ((2R,3S)-AMG 986) (Example 238.0) is a precursor of an *apelin receptor* agonist (EC₅₀=12 nM) and an isomer of Azelaprag (HY-109111) .

HY-P1033S1

*[Pyr1]-Apelin-13, Pro(13C5,15N) TFA*	Isotope-Labeled Compounds	Cardiovascular Disease
[Pyr1]-Apelin-13, Pro( ¹³C5, ¹⁵N) (TFA) is the ¹³C and ¹⁵N labeled isotope of [Pyr1]-Apelin-13(HY-P1033).[Pyr1]-Apelin-13 is a potent and selective endogenous *apelin* receptor agonist .

HY-175818

APJ antagonist-1	Apelin Receptor (APJ)	Cancer
APJ antagonist-1 is an apelin receptor (APJ) antagonist. APJ antagonist-1 shows strong β-arrestin inhibition with an IC₅₀ of 3.1 μM. APJ antagonist-1 selectively inhibits APJ-overexpressing cancer cells and suppresses apelin-induced endothelial cell migration. APJ antagonist-1exhibits high metabolic stability. APJ antagonist-1 can used for the studies of ovarian cancer and tumor angiogenesis .

HY-21796

1-Methyl-3-phenylpropylamine 4-Phenylbutan-2-amine	Apelin Receptor (APJ)	Cardiovascular Disease
ELA-32(human) is a potent critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor .

HY-P3162

*(Ala13)-Apelin-13*	Apelin Receptor (APJ)	Cardiovascular Disease
(Ala13)-Apelin-13 is a potent apelin receptors (APJ) antagonist. (Ala13)-Apelin-13 inhibits gastric motility through vagal cholinergic pathway .

HY-145285

*APJ receptor* agonist 5**	Apelin Receptor (APJ)	Cardiovascular Disease
APJ receptor agonist 5 (compound 3) is a potent and orally active agonist of apelin receptor (APJ) with an EC₅₀ of 0.4 nM. APJ receptor agonist 5 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 5 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 5 leads to improved cardiac function and can be used for researching the HF disease .

HY-P1033S

*[Pyr1]-Apelin-13, Gly(15N) TFA*	Apelin Receptor (APJ)	Cardiovascular Disease
Pyr1]-Apelin-13, Gly(15N) TFA is a Gly ¹⁵N labeled [Pyr1]-Apelin-13. [Pyr1]-Apelin-13 is a highly potent, selective endogenous *apelin* receptor agonist .

HY-P2197A

ELA-11(human) TFA	Apelin Receptor (APJ)	Inflammation/Immunology
ELA-11(human) TFA is a high affinity apelin receptor agonist (K_i=14 nM). ELA-11(human) TFA is a bioactive fragment of ELA-32. ELA-11(human) TFA inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.

HY-145284

*APJ receptor* agonist 4**	Apelin Receptor (APJ)	Cardiovascular Disease
APJ receptor agonist 4 is a potent and orally active agonist of *apelin receptor* (APJ) with EC₅₀ and Ki of 0.06 nM and 0.07 nM respectively. APJ receptor agonist 4 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 4 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 4 leads to improved cardiac function and can be used for researching the HF disease .

HY-103080R

CMF019 (Standard)	Apelin Receptor (APJ) Reference Standards	Cardiovascular Disease
CMF019 (Standard) is the analytical standard of CMF019 (HY-103080). This product is intended for research and analytical applications. CMF019 is an orally active, potent and small molecule agonist at Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ with pK_i values of 8.58, 8.49 and 8.71 for human, rat, and mouse, respectively. CMF019 mimics the beneficial cardiovascular actions of apelin in rodents . Apelin receptor (APJ) is a G protein-coupled receptor (GPCR) activated by the endogenous peptide apelin. CMF019 is promising for research of chronic diseases, such as, pulmonary arterial hypertension .

HY-181540

YL-GB063	Apelin Receptor (APJ)	Cancer
YL-GB063 is an *Apelin receptor* (APJ) antagonist. YL-GB063 inhibits Apelin-induced APJ β-arrestin recruitment (IC₅₀ of 3.1 μM in HTLA cells). YL-GB063 has anti-cancer activity against ovarian cancer .

HY-183777

B-007	Apelin Receptor (APJ) Arrestin	Cardiovascular Disease
B-007 is an AplnR agonist with G protein-biased signaling (EC₅₀ = 11.6 nM). B-007 activates the G protein pathway while abolishing β-arrestin1 and β-arrestin2 signaling. B-007 serves as a scaffold for development of G protein-biased apelin receptor agonists. B-007 can be used for the research of heart failure .

Cat. No.	Product Name	Target	Research Area

HY-P1033

*[Pyr1]-Apelin-13* 4 Publications Verification [pGlu1]-Apelin-13	Apelin Receptor (APJ)	Cardiovascular Disease
[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.

HY-108003

MM 07	Apelin Receptor (APJ)	Cardiovascular Disease
MM 07 is a biased *apelin receptor* agonist, with a K_D of 300 nM in CHO-K1 cells and a K_D of 172 nM in human heart.

HY-P2106

Elabela(19-32) Maximum Cited Publications 6 Publications Verification	Arrestin Apelin Receptor (APJ)	Cardiovascular Disease
Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the G_αi1 and β-arrestin-2 signaling pathways with EC₅₀s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart .

HY-P2197

ELA-11(human)	Apelin Receptor (APJ) Arrestin	Inflammation/Immunology
ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pK_i of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment .

HY-P2106A

Elabela(19-32) TFA Maximum Cited Publications 6 Publications Verification	Apelin Receptor (APJ) Arrestin	Cardiovascular Disease
Elabela(19-32) TFA is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) TFA activates the G_αi1 and β-arrestin-2 signaling pathways with EC₅₀s of 8.6 nM and 166 nM. Elabela(19-32) TFA induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart .

HY-P2196A

ELA-32(human) TFA 1 Publications Verification	Apelin Receptor (APJ)	Cancer
ELA-32(human) TFA is a potent, high affinity apelin receptor agonist (IC₅₀=0.27 nM; K_d=0.51 nM). ELA-32(human) TFA exhibits no binding GPR15 and GPR25. ELA-32(human) TFA activates the PI3K/AKT pathway and promotes self-renewal of hESCs via cell-cycle progression and protein translation. ELA-32(human) TFA also potentiates the TGFβ pathway, priming hESCs toward the endoderm lineage. ELA-32(human) TFA stimulates angiogenesis in HUVEC cells.

HY-P3162A

*(Ala13)-Apelin-13 TFA*	Apelin Receptor (APJ)	Cardiovascular Disease
(Ala13)-Apelin-13 TFA is a potent apelin receptors (APJ) antagonist. (Ala13)-Apelin-13 TFA inhibits gastric motility through vagal cholinergic pathway .

HY-P2249

ELA-21 (human)	Arrestin Apelin Receptor (APJ)	Cardiovascular Disease
ELA-21 (human) is an *apelin receptor* agonist with a pK_i of 8.52. ELA-21 (human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment with subnanomolar potencies. ELA-21 (human) is an agonist in G-protein-dependent and -independent pathways .

HY-P2196

ELA-32(human)	Apelin Receptor (APJ)	Cardiovascular Disease
ELA-32 (human) is a potent critical cardiac developmental peptide that acts through the G-protein–coupled apelin receptor .

HY-P1033S1

*[Pyr1]-Apelin-13, Pro(13C5,15N) TFA*	Isotope-Labeled Compounds	Cardiovascular Disease
[Pyr1]-Apelin-13, Pro( ¹³C5, ¹⁵N) (TFA) is the ¹³C and ¹⁵N labeled isotope of [Pyr1]-Apelin-13(HY-P1033).[Pyr1]-Apelin-13 is a potent and selective endogenous *apelin* receptor agonist .

HY-P3162

*(Ala13)-Apelin-13*	Apelin Receptor (APJ)	Cardiovascular Disease
(Ala13)-Apelin-13 is a potent apelin receptors (APJ) antagonist. (Ala13)-Apelin-13 inhibits gastric motility through vagal cholinergic pathway .

HY-P1033S

*[Pyr1]-Apelin-13, Gly(15N) TFA*	Apelin Receptor (APJ)	Cardiovascular Disease
Pyr1]-Apelin-13, Gly(15N) TFA is a Gly ¹⁵N labeled [Pyr1]-Apelin-13. [Pyr1]-Apelin-13 is a highly potent, selective endogenous *apelin* receptor agonist .

HY-P2197A

ELA-11(human) TFA	Apelin Receptor (APJ)	Inflammation/Immunology
ELA-11(human) TFA is a high affinity apelin receptor agonist (K_i=14 nM). ELA-11(human) TFA is a bioactive fragment of ELA-32. ELA-11(human) TFA inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705991

	APLNR Protein-VLP, Rhesus Macaque (HEK293, His) Apelin receptor; Angiotensin receptor-like 1; G-protein coupled receptor APJ	Rhesus Macaque	HEK293
	APJ-MSP1D1 Protein-VLP, Rhesus Macaque (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

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HY-P1033S1

*[Pyr1]-Apelin-13, Pro(13C5,15N) TFA*
[Pyr1]-Apelin-13, Pro( ¹³C5, ¹⁵N) (TFA) is the ¹³C and ¹⁵N labeled isotope of [Pyr1]-Apelin-13(HY-P1033).[Pyr1]-Apelin-13 is a potent and selective endogenous *apelin* receptor agonist .

HY-P1033S

*[Pyr1]-Apelin-13, Gly(15N) TFA*
Pyr1]-Apelin-13, Gly(15N) TFA is a Gly ¹⁵N labeled [Pyr1]-Apelin-13. [Pyr1]-Apelin-13 is a highly potent, selective endogenous *apelin* receptor agonist .

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