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Elabela(19-32) 

Cat. No.: HY-P2106 Purity: 98.10%
Handling Instructions

Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart.

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Elabela(19-32) Chemical Structure

Elabela(19-32) Chemical Structure

CAS No. : 1886973-05-2

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1 mg USD 100 In-stock
Estimated Time of Arrival: December 31
5 mg USD 390 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].

IC50 & Target

IC50: 8.6 nM (Gαi1) and 166 nM (β-arrestin-2)[1]

In Vitro

Elabela(19-32) (analogue 3) has a Ki of 0.93 nM for binding of radioligand apelin-13[Glp65, Nle75, Tyr77][125I][1].
Elabela(19-32) has an EC50 of 36 nM in HEK293 cells transiently expressing the HA-hAPJ receptor. Elabela(19-32) is slightly less potent than apelin-13 and ELA to elicit receptor internalization[1].
Elabela(19-32) (0.001 to 0.3 nM) has an EC50 of 1.5 pM in inducing changes in left ventricular developed pressure (LVDP) on the Langendorff perfused isolated rat heart[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Elabela(19-32) (analogue 3) is rapidly metabolized in rat plasma (t1/2<2 min)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1707.03

Formula

C₇₅H₁₁₉N₂₅O₁₇S₂

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (58.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5858 mL 2.9291 mL 5.8581 mL
5 mM 0.1172 mL 0.5858 mL 1.1716 mL
10 mM 0.0586 mL 0.2929 mL 0.5858 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Elabela(19-32)
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