2. GPCR/G Protein
  3. Arrestin Apelin Receptor (APJ)
  4. ELA-11(human)

ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment.

For research use only. We do not sell to patients.

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ELA-11(human) Chemical Structure

ELA-11(human) Chemical Structure

CAS No. : 1784687-32-6

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1 mg USD 65 In-stock
5 mg USD 165 In-stock
10 mg USD 250 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of ELA-11(human):

ELA-11(human) Related Antibodies

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  • Biological Activity

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Description

ELA-11(human), a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment[1].

IC50 & Target

pKi: 7.85 (apelin receptor)[1]
In Vitro

ELA-11(human) (1 pM-100 nM) completely inhibits Forskolin-induced cAMP production in a concentration-dependent manner[1].
ELA-11(human) (1 pM-1 μM) stimulates β-arrestin recruitment in a concentration-dependent manner with subnanomolar potencies[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELA-11(human) Related Antibodies
Molecular Weight

1283.56

Formula

C58H90N16O13S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cys-Met-Pro-Leu-His-Ser-Arg-Val-Pro-Phe-Pro
Sequence Shortening

CMPLHSRVPFP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (77.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7791 mL 3.8954 mL 7.7908 mL
5 mM 0.1558 mL 0.7791 mL 1.5582 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.7791 mL 3.8954 mL 7.7908 mL 19.4771 mL
5 mM 0.1558 mL 0.7791 mL 1.5582 mL 3.8954 mL
10 mM 0.0779 mL 0.3895 mL 0.7791 mL 1.9477 mL
15 mM 0.0519 mL 0.2597 mL 0.5194 mL 1.2985 mL
20 mM 0.0390 mL 0.1948 mL 0.3895 mL 0.9739 mL
25 mM 0.0312 mL 0.1558 mL 0.3116 mL 0.7791 mL
30 mM 0.0260 mL 0.1298 mL 0.2597 mL 0.6492 mL
40 mM 0.0195 mL 0.0974 mL 0.1948 mL 0.4869 mL
50 mM 0.0156 mL 0.0779 mL 0.1558 mL 0.3895 mL
60 mM 0.0130 mL 0.0649 mL 0.1298 mL 0.3246 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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ELA-11(human) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELA-11(human)1784687-32-6ArrestinApelin Receptor (APJ)apelinForskolincAMPβ-arrestinInhibitorinhibitorinhibit

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