[Pyr1]-Apelin-13, Gly(15N) TFA 

Pyr1]-Apelin-13, Gly(15N) TFA is a Gly¹⁵N labeled [Pyr1]-Apelin-13. [Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor agonist^[1][2].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

1534.79 (free base)

C₆₉H₁₀₈N₂₁¹⁵NO₁₆S.xC₂HF₃O₂

{Glp}-Arg-Pro-Arg-Leu-Ser-His-Lys--{Gly(15N)}-Pro-Met-Pro-Phe

{Glp}-RPRLSHK-{Gly(15N)}-PMPF

O=C([C@@H]1CCC(N1)=O)N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CCCCN)C([15NH]CC(N3[C@@H](CCC3)C(N[C@@H](CCSC)C(N4[C@@H](CCC4)C(N[C@H](C(O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Serpooshan V, et al. [Pyr1]-Apelin-13 delivery via nano-liposomal encapsulation attenuates pressure overload-induced cardiac dysfunction. Biomaterials. 2015 Jan;37:289-98.  [Content Brief]

  [2]. Hajimashhadi Z, et al. Chronic administration of [Pyr1] apelin-13 attenuates neuropathic pain after compression spinal cord injury in rats. Neuropeptides. 2017 Feb;61:15-22.  [Content Brief]