2. GPCR/G Protein
    Immunology/Inflammation
  3. CXCR
  4. ML339

ML339 

Cat. No.: HY-122197 Purity: 99.88%
COA Handling Instructions

ML339 is a potent and selective CXCR6 (IC50 of 140 nM) antagonist that is selective (IC50 >79 μM) against CXCR5, CXCR4, CCR6 and Apelin receptor (APJ). ML339 holds potential to advance the field of prostate cancer research.

For research use only. We do not sell to patients.

ML339 Chemical Structure

ML339 Chemical Structure

CAS No. : 2579689-83-9

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 121 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
25 mg USD 360 In-stock
Estimated Time of Arrival: December 31
50 mg USD 580 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

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Description

ML339 is a potent and selective CXCR6 (IC50 of 140 nM) antagonist that is selective (IC50 >79 μM) against CXCR5, CXCR4, CCR6 and Apelin receptor (APJ). ML339 holds potential to advance the field of prostate cancer research[1].

IC50 & Target[1]

CXCR6

140 nM (IC50)

Molecular Weight

502.00

Appearance

Solid

Formula

C26H32ClN3O5
CAS No.
SMILES

O=C(C1=CC(OC)=C(C(OC)=C1)OC)N[[email protected]@H]2C[[email protected]@H](CCC[[email protected]]3C2)N3CC(NC4=CC=CC=C4Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 75 mg/mL (149.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9920 mL 9.9602 mL 19.9203 mL
5 mM 0.3984 mL 1.9920 mL 3.9841 mL
10 mM 0.1992 mL 0.9960 mL 1.9920 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.75 mg/mL (7.47 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.88%

COA (249 KB) HNMR (287 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ML3392579689-83-9ML 339ML-339CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR6prostatecancerInhibitorinhibitorinhibit

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