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MM 07 

Cat. No.: HY-108003 Purity: 95.40%
Handling Instructions

MM 07 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart.

For research use only. We do not sell to patients.

MM 07 Chemical Structure

MM 07 Chemical Structure

CAS No. : 1876450-21-3

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10 mM * 1 mL in DMSO USD 1338 In-stock
Estimated Time of Arrival: December 31
1 mg USD 190 In-stock
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10 mg USD 790 In-stock
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Based on 1 publication(s) in Google Scholar

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MM 07 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart.

IC50 & Target

KD: 300 nM (apelin receptor in CHO-K1 cells), 172 nM (apelin receptor in human heart)[1].

In Vitro

MM 07 competes with nanomolar affinities for binding of [Glp65,Nle75,Tyr77] [125I]apelin-13 to human apelin receptors in CHO-K1 cells (KD, 300 nM) and human heart (KD, 172 nM, n=3)[1].

In Vivo

MM 07 causes a dose-dependent increase in cardiac output, and although there is a decrease in vascular resistance, this is without corresponding effects on BP. Administration of SNAP produces a profound fall in BP in both [Pyr1]apelin-13 and MM 07-treated groups; however, although cardiac output is significantly increased in response to SNAP in the MM 07 group, it is significantly reduced in the [Pyr1]apelin-13 group. Neither peptide causes a significant change in heart rate, respiratory rate, or temperature. Both [Pyr1]apelin 13 and MM 07 increases peak velocity above basal levels[1].

Molecular Weight







O=C([[email protected]]1N(CCC1)C(CNC([[email protected]](CCCCN)NC([[email protected]@H](NC([[email protected]]2NC([[email protected]](NC([[email protected]@H](NC([[email protected]@]3([H])N(CCC3)C([[email protected]@](CCCNC(N)=N)([H])NC([[email protected]@H](N)CSSC2)=O)=O)=O)CCCNC(N)=N)=O)([H])CC(C)C)=O)=O)CC4=CN=CN4)=O)=O)=O)N[[email protected]@H](CCSC)C(N5[[email protected]@H](CCC5)C(N[[email protected]](C(O)=O)CC6=CC=CC=C6)=O)=O


Room temperature in continental US; may vary elsewhere.

Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Animal Administration

Rats[1] Rats (230-260 g), anaesthetized with 2% isoflurane, are given a single intravenous bolus (600 nM) of apelin or MM 07 (both n=3)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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