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bile acid sulfation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Metabolite (4) Endogenous Metabolite (12) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (1) Isotope-Labeled Compounds (1) LDLR (1) Mitochondrial Metabolism (1) NF-κB (2) P-glycoprotein (2) p38 MAPK (1) PI3K (1) Pregnane X Receptor (PXR) (1) PROTACs (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) ROCK (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Endocrinology (2) Inflammation/Immunology (4) Metabolic Disease (10) Neurological Disease (1)
Oligonucleotides:	Cholesterol (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0172B

Isolithocholic acid 3β-Hydroxy-5β-cholanic acid; 3-Epilithocholic acid; β-Lithocholic acid	Endogenous Metabolite	Endocrinology
Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate .

HY-113315

3b-Hydroxy-5-cholenoic acid	Endogenous Metabolite	Metabolic Disease
3β-Hydroxy-5-cholenoic acid is a steroidal monohydroxy bile acid and serves as a substrate for sulfation reactions. It is applicable to the research of extrahepatic biliary atresia and recurrent intrahepatic cholestasis of pregnancy .

HY-W353102

Estradiol 17-(β-D-Glucuronide)	Endogenous Metabolite P-glycoprotein	Metabolic Disease
Estradiol 17-(β-D-Glucuronide) is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) can be used in studies related to intrahepatic cholestasis .

HY-129987

Estradiol 17-(β-D-Glucuronide) sodium	Endogenous Metabolite P-glycoprotein	Metabolic Disease
Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) sodium is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) sodium regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) sodium induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) sodium can be used in studies related to intrahepatic cholestasis .

HY-N0430A

Coptisine Sulfate 5 Publications Verification	Indoleamine 2,3-Dioxygenase (IDO) NF-κB p38 MAPK PI3K Akt Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism DNA/RNA Synthesis ROCK LDLR	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Coptisine Sulfate is an orally active and brain-penetrant alkaloid found in Coptis chinensis. Coptisine Sulfate is a reversible, uncompetitive IDO inhibitor with a K_i of 5.8 μM and an IC₅₀ of 6.3 μM. Coptisine Sulfate suppresses neuroinflammation, reduces Aβ plaque burden and shows neuroprotective activity. Coptisine Sulfate shows anti-inflammation activity by blocking NF-κB, MAPK, and PI3K/Akt activation. Coptisine Sulfate inhibits cancer cells proliferation, induces DNA damage, G2/M phase cell cycle arrest, apoptosis, ROS production and mitochondrial dysfunction. Coptisine Sulfate inhibits Rho/ROCK pathway activation, reduces arrhythmia, limits cardiac injury marker release, reduces infarct size, and preserves cardiac function in rat myocardial ischemia/reperfusion models. Coptisine Sulfate downregulates HMGCR and upregulates LDLR and CYP7A1 to modulate cholesterol metabolism, reduces abnormal serum lipid levels, and promotes fecal bile acid excretion. Coptisine Sulfate be used for the research of cancer, hypercholesterolemia, Alzheimer’s disease, inflammatory disorders and cardiovascular disease .

HY-W779068

Chenodeoxycholic acid 3-sulfate disodium	Endogenous Metabolite	Inflammation/Immunology
Chenodeoxycholic acid 3-sulfate disodium is a bile acid. Chenodeoxycholic acid 3-sulfate disodium level corresponds closely with the extent of hepatic dysfunction .

HY-111769

Taurochenodeoxycholate-3-sulfate	Endogenous Metabolite	Metabolic Disease
Taurochenodeoxycholate-3-sulfate is a bile salt found in urine .

HY-113360

Chenodeoxycholic acid 3-sulfate	Endogenous Metabolite	Inflammation/Immunology
Chenodeoxycholic acid 3-sulfate is a bile acid. Chenodeoxycholic acid 3-sulfate level corresponds closely with the extent of hepatic dysfunction .

HY-W1002768

Cholic acid 3-sulfate sodium	Drug Metabolite	Others
Cholic acid 3-sulfate sodium is a metabolite of the primary bile acid Cholic acid (HY-N0324) .

HY-126855A

Cholic acid 7-sulfate sodium	Drug Metabolite	Others
Cholic acid 7-sulfate sodium is a metabolite of the primary bile acid Cholic acid (HY-N0324) .

HY-123063

Petromyzonol 5α-Petromyzonol; 5α-PZ	Others	Others
Petromyzonol (5α-Petromyzonol) is a tetrahydroxy stearol produced by the bile of sea lamprey larvae from the bile acid precursor acetylcholic acid. Petromyzonol sulfate acts as a pheromone and oviposition chemical attractant .

HY-175266

MI1013	PROTACs Cytochrome P450 Pregnane X Receptor (PXR)	Metabolic Disease
MI1013 is a PROTAC PXR degrader (DC₅₀ = 89 nM, D_max = 82%). MI1013 degrades PXR in human hepatocellular carcinoma RG cells (HepaRG). MI1013 specifically and safely regulates CYP3A4 promoter activity through PXR degradation. MI1013 affects several key genes involved in sulfate conjugation (e.g., SULT1E1), bile acid synthesis (CYP7A1), gluconeogenesis (PCK1), ketone synthesis (HMGCS20), and hepatocyte proliferation (MKI67). (Pink: PXR ligand 3: HY-175267, Blue: Pomalidomide-propargyl ligand: HY-W410002, Pink + Black: PXR ligand-Linker Conjugate 1: HY-175268) .

HY-N15830

Chenodeoxycholic acid 7-sulfate sodium	Endogenous Metabolite	Others
Chenodeoxycholic acid 7-sulfate sodium, a bile acid, is a metabolite of Chenodeoxycholic acid (HY-76847) .

HY-N17272

Cholic acid 3-sulfate	Drug Metabolite	Metabolic Disease
Cholic acid 3-sulfate is the sulfated metabolite of Cholic acid (HY-N0324), produced by liver enzyme sulfotransferase-2A1. Cholic acid 3-sulfate is less toxic than the parent compound, thus serving as a detoxification pathway for bile acids. Cholic acid 3-sulfate does not have the effect of stimulating intestinal secretion .

HY-N15828

Glycochenodeoxycholic acid 3-sulfate-d4 disodium	Isotope-Labeled Compounds	Others
Glycochenodeoxycholic acid 3-sulfate-d₄ is the deuterium labeled bile acid .

HY-B0172BR

Isolithocholic acid (Standard) 3β-Hydroxy-5β-cholanic acid (Standard); 3-Epilithocholic acid (Standard); β-Lithocholic acid (Standard)	Reference Standards Endogenous Metabolite	Endocrinology
Isolithocholic acid (Standard) is the analytical standard of Isolithocholic acid. This product is intended for research and analytical applications. Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate[1][2].

HY-W587458

Deoxycholic acid 3-sulfate disodium	Drug Metabolite	Others
Deoxycholic acid 3-sulfate disodium is a steroid bile salt, a sulfate derivative of the bile acid (BA) deoxycholic acid.

HY-N11602

Deoxycholic acid 3-sulfate	Endogenous Metabolite	Metabolic Disease
Deoxycholic acid 3-sulfate is a sulfated metabolite of deoxycholic acid, belonging to the sulfate ester form of secondary bile acids. The proportion of Deoxycholic acid 3-sulfate in serum from both healthy states and cholestatic states is below the limit of detection .

HY-N18490

5α-Cyprinol sulfate	Drug Derivative	Metabolic Disease
5α-Cyprinol sulfate is an orally active bile salt and heterospecific pheromone. 5α-Cyprinol sulfate promotes lipid digestion in fish. 5α-Cyprinol sulfate inhibits taurocholic acid uptake mediated by apical bile salt transporters in rat ileum. 5α-Cyprinol sulfate can be used in studies of fish toxic acute renal failure .

HY-48813

Glycoursodeoxycholic acid 3-sulfate	Endogenous Metabolite NF-κB Interleukin Related	Metabolic Disease
Glycoursodeoxycholic acid 3-sulfate is a glycine-conjugated sulfated bile acid 3-sulfate, which is produced by SULT2A1-mediated sulfation of glycoursodeoxycholic acid (HY-N1424) in the liver. Glycoursodeoxycholic acid 3-sulfate attenuates the anti-inflammatory effect of glycoursodeoxycholic acid and impairs the inhibitory effect on the IL-17 and NF-κB signaling pathways. Glycoursodeoxycholic acid 3-sulfate shows a significant correlation with aortic flow velocity and BNP in patients with aortic stenosis. Glycoursodeoxycholic acid 3-sulfate is mainly used in related studies such as quantitative analysis, quality control and biochemical experiments; it often serves as a reagent for metabolomics analysis and can also be applied to research related to aortic stenosis .

HY-N13266

5β-Cholestane-3α,7α,12α,25,27-pentol	Endogenous Metabolite	Inflammation/Immunology
5β-Cholestane-3α,7α,12α,25,27-pentol is a bile alcohol found in amphibian bile. 5β-Cholestane-3α,7α,12α,25,27-pentol serves as a principal or sole constituent of sulfate-conjugated bile salts in gallbladder bile of the caecilian Dermophis mexicanus. 5β-Cholestane-3α,7α,12α,25,27-pentol appears as a minor constituent in bile of the toad Bufo b. formosus. 5β-Cholestane-3α,7α,12α,25,27-pentol may represent the end product of cholesterol metabolism in the caecilian, as bile acids remain undetected in this organism .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0172B

Isolithocholic acid 3β-Hydroxy-5β-cholanic acid; 3-Epilithocholic acid; β-Lithocholic acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite
Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate .

HY-113315

3b-Hydroxy-5-cholenoic acid	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
3β-Hydroxy-5-cholenoic acid is a steroidal monohydroxy bile acid and serves as a substrate for sulfation reactions. It is applicable to the research of extrahepatic biliary atresia and recurrent intrahepatic cholestasis of pregnancy .

HY-W353102

Estradiol 17-(β-D-Glucuronide)	Structural Classification Monophenols Classification of Application Fields Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite P-glycoprotein
Estradiol 17-(β-D-Glucuronide) is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) can be used in studies related to intrahepatic cholestasis .

HY-129987

Estradiol 17-(β-D-Glucuronide) sodium	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Endocrinology Steroids Source Classification	Endogenous Metabolite P-glycoprotein
Estradiol 17-(β-D-Glucuronide) sodium is a D-ring glucuronide metabolite of natural estrogen formed in the liver. Estradiol 17-(β-D-Glucuronide) sodium is a substrate of the organic anion-transporting polypeptide family (Oatp) and multidrug resistance-associated protein 2 (Mrp2). Estradiol 17-(β-D-Glucuronide) sodium regulates MRP8-mediated transport processes and inhibits MRP8-mediated transport of dehydroepiandrosterone 3-sulfate and taurocholic acid. Estradiol 17-(β-D-Glucuronide) sodium induces immediate, reversible reduction of bile flow and acute intrahepatic cholestasis in female rats without altering the bile acid composition in bile. Estradiol 17-(β-D-Glucuronide) sodium can be used in studies related to intrahepatic cholestasis .

HY-N0430A

Coptisine Sulfate 5 Publications Verification	Alkaloids Structural Classification Chelidonium majus Classification of Application Fields Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields Papaveraceae Source Classification	Indoleamine 2,3-Dioxygenase (IDO) NF-κB p38 MAPK PI3K Akt Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism DNA/RNA Synthesis ROCK LDLR
Coptisine Sulfate is an orally active and brain-penetrant alkaloid found in Coptis chinensis. Coptisine Sulfate is a reversible, uncompetitive IDO inhibitor with a K_i of 5.8 μM and an IC₅₀ of 6.3 μM. Coptisine Sulfate suppresses neuroinflammation, reduces Aβ plaque burden and shows neuroprotective activity. Coptisine Sulfate shows anti-inflammation activity by blocking NF-κB, MAPK, and PI3K/Akt activation. Coptisine Sulfate inhibits cancer cells proliferation, induces DNA damage, G2/M phase cell cycle arrest, apoptosis, ROS production and mitochondrial dysfunction. Coptisine Sulfate inhibits Rho/ROCK pathway activation, reduces arrhythmia, limits cardiac injury marker release, reduces infarct size, and preserves cardiac function in rat myocardial ischemia/reperfusion models. Coptisine Sulfate downregulates HMGCR and upregulates LDLR and CYP7A1 to modulate cholesterol metabolism, reduces abnormal serum lipid levels, and promotes fecal bile acid excretion. Coptisine Sulfate be used for the research of cancer, hypercholesterolemia, Alzheimer’s disease, inflammatory disorders and cardiovascular disease .

HY-W779068

Chenodeoxycholic acid 3-sulfate disodium	Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Chenodeoxycholic acid 3-sulfate disodium is a bile acid. Chenodeoxycholic acid 3-sulfate disodium level corresponds closely with the extent of hepatic dysfunction .

HY-111769

Taurochenodeoxycholate-3-sulfate	Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Taurochenodeoxycholate-3-sulfate is a bile salt found in urine .

HY-113360

Chenodeoxycholic acid 3-sulfate	Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Chenodeoxycholic acid 3-sulfate is a bile acid. Chenodeoxycholic acid 3-sulfate level corresponds closely with the extent of hepatic dysfunction .

HY-W1002768

Cholic acid 3-sulfate sodium	Lipid	Drug Metabolite
Cholic acid 3-sulfate sodium is a metabolite of the primary bile acid Cholic acid (HY-N0324) .

HY-126855A

Cholic acid 7-sulfate sodium	Lipid	Drug Metabolite
Cholic acid 7-sulfate sodium is a metabolite of the primary bile acid Cholic acid (HY-N0324) .

HY-123063

Petromyzonol 5α-Petromyzonol; 5α-PZ	Structural Classification Marine natural products Marine microorganism Steroids Source Classification	Others
Petromyzonol (5α-Petromyzonol) is a tetrahydroxy stearol produced by the bile of sea lamprey larvae from the bile acid precursor acetylcholic acid. Petromyzonol sulfate acts as a pheromone and oviposition chemical attractant .

HY-N15830

Chenodeoxycholic acid 7-sulfate sodium	Lipid	Endogenous Metabolite
Chenodeoxycholic acid 7-sulfate sodium, a bile acid, is a metabolite of Chenodeoxycholic acid (HY-76847) .

HY-N17272

Cholic acid 3-sulfate	Structural Classification Endogenous metabolite Steroids Source Classification	Drug Metabolite
Cholic acid 3-sulfate is the sulfated metabolite of Cholic acid (HY-N0324), produced by liver enzyme sulfotransferase-2A1. Cholic acid 3-sulfate is less toxic than the parent compound, thus serving as a detoxification pathway for bile acids. Cholic acid 3-sulfate does not have the effect of stimulating intestinal secretion .

HY-B0172BR

Isolithocholic acid (Standard) 3β-Hydroxy-5β-cholanic acid (Standard); 3-Epilithocholic acid (Standard); β-Lithocholic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
Isolithocholic acid (Standard) is the analytical standard of Isolithocholic acid. This product is intended for research and analytical applications. Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate[1][2].

HY-W587458

Deoxycholic acid 3-sulfate disodium	Triterpenes Structural Classification Terpenoids Endogenous metabolite Source Classification	Drug Metabolite
Deoxycholic acid 3-sulfate disodium is a steroid bile salt, a sulfate derivative of the bile acid (BA) deoxycholic acid.

HY-N11602

Deoxycholic acid 3-sulfate	Triterpenes Structural Classification Terpenoids Endogenous metabolite Source Classification	Endogenous Metabolite
Deoxycholic acid 3-sulfate is a sulfated metabolite of deoxycholic acid, belonging to the sulfate ester form of secondary bile acids. The proportion of Deoxycholic acid 3-sulfate in serum from both healthy states and cholestatic states is below the limit of detection .

HY-N18490

5α-Cyprinol sulfate	Structural Classification Animals Steroids Source Classification	Drug Derivative
5α-Cyprinol sulfate is an orally active bile salt and heterospecific pheromone. 5α-Cyprinol sulfate promotes lipid digestion in fish. 5α-Cyprinol sulfate inhibits taurocholic acid uptake mediated by apical bile salt transporters in rat ileum. 5α-Cyprinol sulfate can be used in studies of fish toxic acute renal failure .

HY-N13266

5β-Cholestane-3α,7α,12α,25,27-pentol	Structural Classification Natural Products Animals Steroids Source Classification	Endogenous Metabolite
5β-Cholestane-3α,7α,12α,25,27-pentol is a bile alcohol found in amphibian bile. 5β-Cholestane-3α,7α,12α,25,27-pentol serves as a principal or sole constituent of sulfate-conjugated bile salts in gallbladder bile of the caecilian Dermophis mexicanus. 5β-Cholestane-3α,7α,12α,25,27-pentol appears as a minor constituent in bile of the toad Bufo b. formosus. 5β-Cholestane-3α,7α,12α,25,27-pentol may represent the end product of cholesterol metabolism in the caecilian, as bile acids remain undetected in this organism .

Cat. No.	Product Name	Chemical Structure

HY-N15828

Glycochenodeoxycholic acid 3-sulfate-d4 disodium
Glycochenodeoxycholic acid 3-sulfate-d₄ is the deuterium labeled bile acid .

Cat. No.	Product Name		Classification

HY-B0172B

Isolithocholic acid 3β-Hydroxy-5β-cholanic acid; 3-Epilithocholic acid; β-Lithocholic acid		Cholesterol
Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate .

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bile acid sulfation

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products