Glycoursodeoxycholic acid 3-sulfate
Glycoursodeoxycholic acid 3-sulfate is a glycine-conjugated sulfated bile acid 3-sulfate, which is produced by SULT2A1-mediated sulfation of glycoursodeoxycholic acid (HY-N1424) in the liver. Glycoursodeoxycholic acid 3-sulfate attenuates the anti-inflammatory effect of glycoursodeoxycholic acid and impairs the inhibitory effect on the IL-17 and NF-κB signaling pathways. Glycoursodeoxycholic acid 3-sulfate shows a significant correlation with aortic flow velocity and BNP in patients with aortic stenosis. Glycoursodeoxycholic acid 3-sulfate is mainly used in related studies such as quantitative analysis, quality control and biochemical experiments; it often serves as a reagent for metabolomics analysis and can also be applied to research related to aortic stenosis.
For research use only. We do not sell to patients.
- CAS No.: 133429-88-6
- Formula: C26H43NO8S
- Molecular Weight:529.69
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
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p65 |
IL-6 |
IL-17A |
Glycoursodeoxycholic acid 3-sulfate is accurately and precisely quantified in human blank urine across a concentration range of 20-2000 ng/mL via the LC/ESI-MS/MS method[1].
Glycoursodeoxycholic acid 3-sulfate (100 μM; 24 h) does not reverse ISO-induced upregulation of IL-17 and NF-κB inflammatory pathways in human embryonic stem cell-derived cardiomyocytes, demonstrating diminished anti-inflammatory activity compared to unsulfonated Glycoursodeoxycholic acid (HY-N1424)[2].
Glycoursodeoxycholic acid 3-sulfate (50-100 μM; 24 h) weakly inhibits ISO-induced upregulation of IL-17A, IL-6, and NF-κB p65 protein expression in human embryonic stem cell-derived cardiomyocytes, showing diminished anti-inflammatory efficacy relative to unsulfonated glycoursodeoxycholic acid[2].
Glycoursodeoxycholic acid 3-sulfate (100 μM; 24 h) does not effectively prevent ISO-induced nuclear translocation of NF-κB p65 in human embryonic stem cell-derived cardiomyocytes, indicating impaired anti-inflammatory function relative to unsulfonated glycoursodeoxycholic acid[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human embryonic stem cell-derived cardiomyocytes (hESC-CMs)
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Concentration:50, 100 μM
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Incubation Time:24 h (pretreatment)
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Result:Exhibited weaker inhibition of ISO-upregulated IL-17A, IL-6, and NF-κB p65 protein expression.
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Cell Line:human embryonic stem cell-derived cardiomyocytes (hESC-CMs)
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Concentration:100 μM
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Incubation Time:24 h (pretreatment)
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Result:Had limited efficacy in preventing ISO-induced nuclear translocation of NF-κB p65, whereas unsulfonated glycoursodeoxycholic acid reduced NF-κB p65 nuclear localization.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 133429-88-6
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Molecular Weight 529.69
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Formula C26H43NO8S
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SMILES
O[C@@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CCC(NCC(O)=O)=O)C)([H])[C@@]4([C@](C[C@@H](CC4)OS(=O)(O)=O)([H])C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Goto T, et al. LC/ESI-tandem mass spectrometric determination of bile acid 3-sulfates in human urine 3beta-Sulfooxy-12alpha-hydroxy-5beta-cholanoic acid is an abundant nonamidated sulfate. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;846(1-2):69-77. [Content Brief]
[2]. Zhu M, et al. Glycoursodeoxycholic acid 3 sulfate sodium links hemodynamics and bile acid metabolism in aortic stenosis. J Adv Res. Published online September 9, 2025. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glycoursodeoxycholic acid 3-sulfate Related Classifications
HY-48813 Related Classifications
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