cGMP-dependent

By Targets:	Myosin (3) Parasite (3) Phosphodiesterase (PDE) (1) PKA (3) PKC (3) PKG (4) Potassium Channel (1) ROCK (3) Ser/Thr Protease (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Infection (3) Metabolic Disease (2) Neurological Disease (3)
Click Chemistry:	Alkynes (1)

Targets Recommended: Apical Sodium-Dependent Bile Acid Transporter CaMK CDK SNIPERs DNA-PK VDAC SGLT PDK-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1561

PKG Substrate

PKG Neurological Disease

PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).
HY-P1292

PKG inhibitor peptide

PKG Cancer

PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .
HY-P1292A

PKG inhibitor peptide TFA

PKG Cancer

PKG inhibitor peptide TFA is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .
HY-145233

PfPKG-IN-1

Parasite Infection

PfPKG-IN-1 is a imidazole-based inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG).
HY-153538

AP-C2

Ser/Thr Protease Metabolic Disease

AP-C2 is a potent guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC₅₀ of 5.2 .

PKG Substrate	PKG	Neurological Disease
PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).

PKG inhibitor peptide	PKG	Cancer
PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .

PKG inhibitor peptide TFA	PKG	Cancer
PKG inhibitor peptide TFA is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .

PfPKG-IN-1	Parasite	Infection
PfPKG-IN-1 is a imidazole-based inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG).

AP-C2	Ser/Thr Protease	Metabolic Disease
AP-C2 is a potent *guanosine 3',5'-cyclic monophosphate (cGMP)-dependent* protein kinase II (cGKII) inhibitor with a pIC₅₀** of 5.2 .

HY-161309

PfPKG-IN-2	Parasite	Infection
PfPKG-IN-2 (compound 53) is a potent Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) inhibitor with an IC₅₀ value of 13 nM. PfPKG-IN-2 shows antiparasitic activity .

HY-153540

AP-C4	Others	Others
AP-C4 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 5.2. AP-C3 does not inhibit cGKII-dependent anion secretion .

HY-153541

AP-C7	Others	Others
AP-C7 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 5.0. AP-C7 only weakly inhibits cGKII-dependent anion secretion .

HY-153537

AP-C1	Others	Others
AP-C1 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.5. AP-C1 only weakly inhibits cGKII-dependent anion secretion .

HY-153539

AP-C3	Others	Others
AP-C3 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.3. AP-C3 only weakly inhibits cGKII-dependent anion secretion .

HY-102050

PF-05085727	Phosphodiesterase (PDE)	Neurological Disease
PF-05085727 is a potent, selective and brain penetrant inhibitor of cGMP-dependent PDE2A (IC₅₀=2 nM). PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11 .

HY-153542

AP-C6	Others	Others
AP-C6 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.5. AP-C6 concentration-dependently inhibits human cGKII activity in vitro. AP-C6 potentiate cAMP signaling by PDE inhibition .

HY-110221

Rp-8-pCPT-cGMPS sodium	PKG	Neurological Disease
Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner .

HY-100984

HA-100 1 Publications Verification	PKA PKC Myosin ROCK	Cancer
HA-100 is a potent protein kinase inhibitor, with IC₅₀s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), *cAMP-dependent* protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK** inhibitor .

HY-100984A

HA-100 hydrochloride	PKA PKC Myosin ROCK	Cancer
HA-100 hydrochloride is a potent protein kinase inhibitor, with IC₅₀s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor .

HY-12880

HA-100 dihydrochloride	Myosin PKA PKC ROCK	Cancer
HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC₅₀s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor .

HY-130354

*Dibutyryl-cGMP* sodium** 2 Publications Verification Bt2cGMP sodium	Potassium Channel	Cardiovascular Disease
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits the release of [ ³H]-arachidonic acid from γ thrombin-stimulated human platelets. Dibutyryl-cGMP sodium induces peripheral antinociception via activation of ATP-sensitive K ⁺ channels .

HY-101525

MBP146-78

2 Publications Verification

Parasite Infection

MBP146-78 is a potent and selective inhibitor of cGMP dependent protein kinases.

MBP146-78 2 Publications Verification	Parasite	Infection
MBP146-78 is a potent and selective inhibitor of *cGMP* dependent protein kinases.

HY-N6791

KT5823 2 Publications Verification
KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an K_i value of 0.23 μM, it also inhibits PKA and PKC with K_i values of 10 μM and 4 μM, respectively . KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na ⁺/I ^- symporter) NIS expression, and iodide uptake in thyroid cells . KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation .

Cat. No.	Product Name	Target	Research Area

HY-P1561

PKG Substrate

PKG Neurological Disease

PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).
HY-P1292

PKG inhibitor peptide

PKG Cancer

PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .
HY-P1292A

PKG inhibitor peptide TFA

PKG Cancer

PKG inhibitor peptide TFA is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .
HY-P2692A

DT-2

Peptides Cancer

DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG). DT-2 inhibits PKG catalyzed phosphorylation (K_{i_{: 12.5 nM) .}}

PKG Substrate	PKG	Neurological Disease
PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).

PKG inhibitor peptide	PKG	Cancer
PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .

PKG inhibitor peptide TFA	PKG	Cancer
PKG inhibitor peptide TFA is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .

DT-2	Peptides	Cancer
DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG). DT-2 inhibits PKG catalyzed phosphorylation (K_{i_{: 12.5 nM) .}}

Species:	Human (4)
Tag:	His (2) GST (2)
Source:	HEK293 (1) Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P701759

	PRKG2 Protein, Human (Sf9, GST) PRKG2; cGMP-dependent protein kinase 2; cGK 2; cGK2; cGMP-dependent protein kinase II; cGKII	Human	Sf9 insect cells
	PRKG2 protein is a key regulator that activates CFTR to promote intestinal secretion and affect bone growth. It phosphorylates CFTR, coordinating cGMP-dependent translocation in the jejunum. PRKG2 Protein, Human (Sf9, GST) is the recombinant human-derived PRKG2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of PRKG2 Protein, Human (Sf9, GST) is 762 a.a., .

HY-P71234

	PRKG1 Protein, Human (HEK293, His) cGMP-dependent Protein Kinase 1; cGK 1; cGK1; cGMP-dependent Protein Kinase I; cGKI; PRKG1; PRKG1B; PRKGR1A; PRKGR1B	Human	HEK293
	PRKG1, a serine/threonine protein kinase, mediates the NO/csignaling pathway, phosphorylating various cellular proteins. It influences platelet activation, smooth muscle contraction, cardiac function, CNS processes, and more. PRKG1 regulates intracellular calcium levels, inhibits IP3-induced Ca(2+) release, and phosphorylates channels like KCNMA1 and TRPC. It inactivates RhoA, affecting processes like vesicle trafficking and myosin light chain phosphorylation for vasorelaxation. NO-induced PRKG1 activation also alters gene expression, influencing smooth muscle-specific proteins and limiting smooth muscle cell migration. Additionally, it regulates VASP functions in platelets and smooth muscle. PRKG1 Protein, Human (HEK293, His) is the recombinant human-derived PRKG1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PRKG1 Protein, Human (HEK293, His) is 685 a.a., with molecular weight of ~75.0 kDa.

HY-P74647

	PDE2A Protein, Human (sf9, His) cGMP-dependent 3',5'-cyclic phosphodiesterase; CGS-PDE; PDE2A	Human	Sf9 insect cells
	PDE2A is a cGMP-activated cyclic nucleotide phosphodiesterase that exhibits dual specificity for the second messengers cAMP and cGMP, key regulators in various physiological processes. PDE2A exhibits higher efficiency by covering cAMP and plays an important role in cell growth and migration. PDE2A Protein, Human (sf9, His) is the recombinant human-derived PDE2A protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of PDE2A Protein, Human (sf9, His) is 686 a.a., with molecular weight of ~80.73 kDa.

HY-P702647

PRKG1 Protein, Human (sf9, GST)

PRKG1; protein kinase cGMP-dependent 1; PKG; cGK; AAT8; PKG1; cGK1; cGKI; cGK 1; PRKG1B; PRKGR1B; cGKI-BETA; cGKI-alpha
Human Sf9 insect cells


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Cat. No.	Product Name		Classification

HY-130530

AP-C5		Alkynes
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 7.2, which can be used for the research of diarrheal disease . AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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