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chromatin condensation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Antibiotic (1) Apoptosis (6) Bcl-2 Family (1) Biochemical Assay Reagents (1) Caspase (4) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (3) DNA/RNA Synthesis (2) Endogenous Metabolite (3) Environmental Pollutants (1) GABA Receptor (1) HDAC (1) HIV (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Mitochondrial Metabolism (1) NO Synthase (1) Parasite (2) PARP (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1)
By Research Areas:	Cancer (6) Infection (3) Inflammation/Immunology (2) Neurological Disease (1)

By Targets:

ADC Payload (1)

Antibiotic (1)

Apoptosis (6)

Bcl-2 Family (1)

Biochemical Assay Reagents (1)

Caspase (4)

DNA Alkylator/Crosslinker (1)

DNA Methyltransferase (3)

DNA/RNA Synthesis (2)

Endogenous Metabolite (3)

Environmental Pollutants (1)

GABA Receptor (1)

HDAC (1)

HIV (1)

Isotope-Labeled Compounds (1)

MDM-2/p53 (1)

Mitochondrial Metabolism (1)

NO Synthase (1)

Parasite (2)

PARP (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (1)

By Research Areas:

Cancer (6)

Infection (3)

Inflammation/Immunology (2)

Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: SWI/SNF Complex

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W012078

5-Methyl-2'-deoxycytidine 3 Publications Verification 5-Methyldeoxycytidine	DNA Methyltransferase Endogenous Metabolite	Others
5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

HY-B0837

Emamectin Benzoate 1 Publications Verification MK-244	Environmental Pollutants Parasite Apoptosis Reactive Oxygen Species (ROS) GABA Receptor	Infection Neurological Disease
Emamectin Benzoate (MK-244) is an orally active nervoussystem toxicant by binding g-aminobutyric (GABA) receptor in insects. Emamectin Benzoate is one of semi-synthetic derivative of Avermectin (HY-15311) with a broadspectrum of insecticidal and acaricidal activity. Emamectin Benzoate induces ROS-mediated DNA damage and cell apoptosis. Emamectin Benzoate, a mixture of the natural Emamectin B1a benzoate and Emamectin B1b benzoate, has the main component of Emamectin B1a benzoate .

HY-141591

CYT296	Biochemical Assay Reagents	Others
CYT296 is a target *chromatin* de-condensation compound. CYT296 can improve the induction of induced pluripotent stem cell (iPSCs) mediated by defined factors (OSKM) and induce an open chromatin state in Mouse Embryonic Fibroblast (MEFs) to facilitate somatic cell reprogramming. CYT296 can be used for cell replacement therapies and drug screening research .

HY-W740027

5-Methyl-2'-deoxycytidine-d3 5-Methyldeoxycytidine-d₃	Isotope-Labeled Compounds DNA Methyltransferase Endogenous Metabolite	Others
5-Methyl-2'-deoxycytidine-d₃ (5-Methyldeoxycytidine-d₃) is the deuterium labeled Methyl-2'-deoxycytidine (HY-W012078). 5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

HY-12455

Duocarmycin A	ADC Payload Antibiotic DNA Alkylator/Crosslinker Apoptosis Caspase	Cancer
Duocarmycin A is an antitumor antibiotic and DNA alkylating agent with broad-spectrum antibacterial activity, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). Duocarmycin A selectively binds to the AT-rich minor groove of DNA, forms covalent adducts by alkylating the adenine N3 residue, thereby disrupting DNA structure and inhibiting its replication and transcription. Duocarmycin A induces apoptosis, sub-G1 phase accumulation and chromatin condensation, reduces the levels of pro-caspase-3/9, and induces p53-independent p21 expression. Duocarmycin A is widely used in the research of various malignancies, including leukemia, sarcoma, glioblastoma, as well as multiple solid tumor models such as lung cancer, breast cancer, and colorectal cancer .

HY-121199

Germanicol	Apoptosis	Cancer
Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage .

HY-12926

ST7612AA1	HIV HDAC DNA/RNA Synthesis	Infection
ST7612AA1 is a histone deacetylase (HDAC) inhibitor that controls chromatin condensation and DNA transcription by removing acetyl groups from histones. ST7612AA1 is also a potent HIV reactivation inducer, and its reactivation activity is exerted without activating or proliferating CD4+T cells, and can be used in the study of HIV reactivation strategies and elimination of viral reservoirs .

HY-W012078R

5-Methyl-2'-deoxycytidine (Standard) 1 Publications Verification 5-Methyldeoxycytidine (Standard)	Reference Standards DNA Methyltransferase Endogenous Metabolite	Others
5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

HY-173356

Antiparasitic agent-26	Parasite Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Antiparasitic agent-26 (Compound 8) is an antiparasitic compound that potently inhibits the growth of Naegleria fowleri, with IC₅₀ values of 22.87 μM (trophozoite stage) and 25.16 μM (cyst stage). Antiparasitic agent-26 exerts its antiparasitic activity by inducing programmed cell death, including cytoplasmic calcium accumulation, mitochondrial membrane potential collapse, ATP synthesis inhibition, ROS accumulation, and chromatin condensation. Antiparasitic agent-26 can be used in the research of primary amoebic meningoencephalitis (PAM) .

HY-N8617

Trijuganone C	DNA/RNA Synthesis Caspase PARP Bcl-2 Family Mitochondrial Metabolism Apoptosis	Cancer
Trijuganone C is a tanshinone-type diterpenoid compound. Trijuganone C can be isolated from the roots of Salvia miltiorrhiza Bunge. Trijuganone C induces chromatin condensation, DNA fragmentation, activation of Caspase-3, -8 and -9, as well as cleavage of PARP. Trijuganone C activates Bid and Bax, leading to loss of mitochondrial membrane potential and inducing the release of cytochrome c from mitochondria into the cytosol. Trijuganone C exerts antiproliferative effects through Apoptosis induction mediated by Mitochondrial dysfunction and Caspase activation. Trijuganone C exhibits significant antiproliferative activity against leukemia cells and colon cancer cells .

HY-149523

Anticancer agent 157	Apoptosis NO Synthase Caspase	Inflammation/Immunology Cancer
Anticancer agent 157 (compound 15) is a NO inhibitor (IC₅₀=0.62 μg/mL) with anti-inflammatory and anticancer activities. Anticancer agent 157 can bind to iNOS (inducible NO synthase) and caspase 8, causing nuclear fragmentation and chromatin condensation, inducing apoptosis. Anticancer agent 157 inhibits HT29 colon cancer cells (IC₅₀=2.45 μg/mL), Hep-G2 liver cancer cells (IC₅₀=3.25 μg/mL), and B16-F10 murine melanoma cells (IC₅₀=3.84 μg/mL) .

HY-N11764

β-Santalol	Apoptosis Caspase	Cancer
β-Santalol is a sesquiterpene alcohol with apoptosis (apoptosis)-inducing activity and cytotoxic activity. β-Santalol activates caspase-3, induces nuclear chromatin condensation, and promotes the formation of apoptotic bodies. β-Santalol targets cancer cells. β-Santalol can be used in research related to promyelocytic leukemia, lung adenocarcinoma, and oral squamous cell carcinoma .

HY-121901

Safrole oxide	MDM-2/p53	Cancer
Safrole oxide is a p53 modulator that upregulates the expression of the p53 tumor suppressor protein, linking cell cycle arrest to the apoptotic process. Safrole oxide induces apoptosis in lung cancer cells without triggering necrosis. Safrole oxide can be used in lung cancer-related research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W012078

5-Methyl-2'-deoxycytidine 3 Publications Verification 5-Methyldeoxycytidine	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	DNA Methyltransferase Endogenous Metabolite
5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

HY-121199

Germanicol	Triterpenes Euphorbia boetica Terpenoids Euphorbiaceae Plants Source Classification	Apoptosis
Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage .

HY-W012078R

5-Methyl-2'-deoxycytidine (Standard) 1 Publications Verification 5-Methyldeoxycytidine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards DNA Methyltransferase Endogenous Metabolite
5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

HY-N8617

Trijuganone C	Quinones Structural Classification Labiatae Samanea saman (Jacq.) Merr. Benzene Quinones Plants Naphthalene Quinones Source Classification	DNA/RNA Synthesis Caspase PARP Bcl-2 Family Mitochondrial Metabolism Apoptosis
Trijuganone C is a tanshinone-type diterpenoid compound. Trijuganone C can be isolated from the roots of Salvia miltiorrhiza Bunge. Trijuganone C induces chromatin condensation, DNA fragmentation, activation of Caspase-3, -8 and -9, as well as cleavage of PARP. Trijuganone C activates Bid and Bax, leading to loss of mitochondrial membrane potential and inducing the release of cytochrome c from mitochondria into the cytosol. Trijuganone C exerts antiproliferative effects through Apoptosis induction mediated by Mitochondrial dysfunction and Caspase activation. Trijuganone C exhibits significant antiproliferative activity against leukemia cells and colon cancer cells .

HY-N11764

β-Santalol	Structural Classification Natural Products Santalum spicatum A. DC. Plants Source Classification Santalaceae	Apoptosis Caspase
β-Santalol is a sesquiterpene alcohol with apoptosis (apoptosis)-inducing activity and cytotoxic activity. β-Santalol activates caspase-3, induces nuclear chromatin condensation, and promotes the formation of apoptotic bodies. β-Santalol targets cancer cells. β-Santalol can be used in research related to promyelocytic leukemia, lung adenocarcinoma, and oral squamous cell carcinoma .

Cat. No.	Product Name	Chemical Structure

HY-W740027

5-Methyl-2'-deoxycytidine-d3
5-Methyl-2'-deoxycytidine-d₃ (5-Methyldeoxycytidine-d₃) is the deuterium labeled Methyl-2'-deoxycytidine (HY-W012078). 5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

5-Methyl-2'-deoxycytidine-d3

5-Methyl-2'-deoxycytidine-d₃ (5-Methyldeoxycytidine-d₃) is the deuterium labeled Methyl-2'-deoxycytidine (HY-W012078). 5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

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chromatin condensation

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
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